News & Publications for:

Fumihiko Urano

A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome

Posted on December 18, 2014

Simin Lu, Kohsuke Kanekura, Takashi Hara, Jana Mahadevan, Larry D. Spears, Christine M. Oslowski, Rita Martinez, Mayu Yamazaki-Inoue, Masashi Toyoda, Amber Neilson, Patrick Blanner, Cris M. Brown, Clay F. Semenkovich, Bess A. Marshall, Tamara Hershey, Akihiro Umezawa, Peter A. Greer, and Fumihiko Urano; 2014 Proceedings of the National Academy of Sciences of the United States of America, 11(49), p E5292-E5301 Read More

Posted in: HPAN, Neurodegeneration, Neurogenetics, Publications Faculty: ,

Calcium efflux from the endoplasmic reticulum leads to β-cell death

Posted on April 10, 2014

Takashi Hara, Jana Mahadevan, Kohsuke Kanekura, Mariko Hara, Simin Lu, Fumikiho Urano; 2014 Endocrinology 155(3) pp. 758-768 Read More

Posted in: HPAN, Neurodegeneration, Publications Faculty:

WFS1 Is a Novel Component of the Unfolded Protein Response and Maintains Homeostasis of the Endoplasmic Reticulum in Pancreatic β-Cells

Posted on February 11, 2014

Fonseca, S.G., Fukuma, M., Lipson, K., Nguyen, L.X., Allen, J.R., Oka, Y., and Urano F.; J Biol Chem, 280(47): 39609-615, 2005. Read More

Posted in: HPAN, Neurodegeneration, Publications Faculty:

Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells

Posted on February 11, 2014

Fonseca, S.G., Ishigaki, S., Oslowski, C.M, Lu, S., Lipson, K.L., Ghosh, R., Hayashi, E., Ishihara, H., Oka, Y., Permutt, M.A., and Urano, F.; Journal of Clinical Invesigation, 120(3): 744-55, 2010. Read More

Posted in: HPAN, Neurodegeneration, Publications Faculty:

Thioredoxin-Interacting Protein Mediates ER Stress-Induced β Cell Death through Initiation of the Inflammasome

Posted on February 11, 2014

Oslowski CM, Hara T, O’Sullivan-Murphy B, Kanekura K, Lu S, Hara M, Ishigaki S, Hayashi E, Hui ST, Greiner D, Kaufman RJ, Bortell R, Urano F. ; Cell Metabolism, 16(2): 265-7, 2012. Read More

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