Fumihiko Urano

Calcium efflux from the endoplasmic reticulum leads to β-cell death

Posted on April 10, 2014

Takashi Hara, Jana Mahadevan, Kohsuke Kanekura, Mariko Hara, Simin Lu, Fumikiho Urano; 2014 Endocrinology 155(3) pp. 758-768 Read More

WFS1 Is a Novel Component of the Unfolded Protein Response and Maintains Homeostasis of the Endoplasmic Reticulum in Pancreatic β-Cells

Posted on February 11, 2014

Fonseca, S.G., Fukuma, M., Lipson, K., Nguyen, L.X., Allen, J.R., Oka, Y., and Urano F.; J Biol Chem, 280(47): 39609-615, 2005. Read More

Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells

Posted on February 11, 2014

Fonseca, S.G., Ishigaki, S., Oslowski, C.M, Lu, S., Lipson, K.L., Ghosh, R., Hayashi, E., Ishihara, H., Oka, Y., Permutt, M.A., and Urano, F.; Journal of Clinical Invesigation, 120(3): 744-55, 2010. Read More

Thioredoxin-Interacting Protein Mediates ER Stress-Induced β Cell Death through Initiation of the Inflammasome

Posted on February 11, 2014

Oslowski CM, Hara T, O’Sullivan-Murphy B, Kanekura K, Lu S, Hara M, Ishigaki S, Hayashi E, Hui ST, Greiner D, Kaufman RJ, Bortell R, Urano F. ; Cell Metabolism, 16(2): 265-7, 2012. Read More

Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion

Posted on February 11, 2014

Fonseca, S, Urano F, Weir G, Gromada J, and Burcin M.; Nature Cell Biol, 1105-12, 2012. Read More