Fumihiko Urano

WFS1 Is a Novel Component of the Unfolded Protein Response and Maintains Homeostasis of the Endoplasmic Reticulum in Pancreatic β-Cells

Posted on February 11, 2014

Fonseca, S.G., Fukuma, M., Lipson, K., Nguyen, L.X., Allen, J.R., Oka, Y., and Urano F.; J Biol Chem, 280(47): 39609-615, 2005. Read More

Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells

Posted on February 11, 2014

Fonseca, S.G., Ishigaki, S., Oslowski, C.M, Lu, S., Lipson, K.L., Ghosh, R., Hayashi, E., Ishihara, H., Oka, Y., Permutt, M.A., and Urano, F.; Journal of Clinical Invesigation, 120(3): 744-55, 2010. Read More

Thioredoxin-Interacting Protein Mediates ER Stress-Induced β Cell Death through Initiation of the Inflammasome

Posted on February 11, 2014

Oslowski CM, Hara T, O’Sullivan-Murphy B, Kanekura K, Lu S, Hara M, Ishigaki S, Hayashi E, Hui ST, Greiner D, Kaufman RJ, Bortell R, Urano F. ; Cell Metabolism, 16(2): 265-7, 2012. Read More

Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion

Posted on February 11, 2014

Fonseca, S, Urano F, Weir G, Gromada J, and Burcin M.; Nature Cell Biol, 1105-12, 2012. Read More

Autosomal Dominant Diabetes Arising From a Wolfram Syndrome 1 Mutation

Posted on February 11, 2014

Bonnycastle LL, Chines PS, Hara T, Huyghe JR, Swift AJ, Heikinheimo P, Mahadevan J, Peltonen S, Huopio H, Nuutila P, Narisu N, Goldfeder RL, Stitzel ML, Lu S, Boehnke M, Urano F, Collins FS, Laakso M. ; Diabetes, 62(11): 3943-50, 2013 Read More