News & Publications for:

John Cirrito

The sleep-wake cycle regulates brain interstitial fluid tau in mice and csf tau in humans

Posted on February 28, 2019

Jerrah K. Holth, Sarah K. Fritschi, Chanung Wang, Nigel P. Pedersen, John R. Cirrito, Thomas E. Mahan, Mary Beth Finn, Melissa Manis, Joel C. Geerling, Patrick M. Fuller, Brendan P. Lucey, David M. Holtzman. Science 2019 Read More

Posted in: Clocks & Sleep, HPAN, Neurodegeneration, Publications Faculty: , ,

Redundant Gs-coupled serotonin receptors regulate amyloid-β metabolism in vivo

Posted on January 9, 2019

Jonathan R. Fisher, Clare E. Wallace, Danielle L. Tripoli, Yvette I. Sheline and John R. Cirrito. Mol Neurodegener. 2016 Jun 18;11(1):45. Read More

Posted in: HPAN, Neurodegeneration, Pilot Projects, Publications Faculty:

AMPA-ergic regulation of amyloid-β levels in an Alzheimer’s disease mouse model

Posted on May 31, 2018

Jane C. Hettinger, Hyo Lee, Guojun Bu, David M. Holtzman and John R. Cirrito. Molecular Neurodegeneration, Volume 13, Issue 1, 15 May 2018, Article number 22 Read More

Posted in: Clocks & Sleep, HPAN, Neurodegeneration, Publications Faculty: ,

Combination anti-Aß treatment maximizes cognitive recovery and rebalances mTOR signaling in APP mice

Posted on May 25, 2018

Angie C.A. Chiang, Stephanie W. Fowler, Ricky R. Savjani, Susan G. Hilsenbeck, Clare E. Wallace, John R. Cirrito, Pritam Das, Joanna L. Jankowsky . Journal of Experimental Medicine, Volume 215, Issue 5, 1 May 2018, Pages 1349-1364 Read More

Posted in: HPAN, Neurodegeneration, Publications Faculty:

An antidepressant decreases CSF Aβ production in healthy individuals and in transgenic AD mice

Posted on June 28, 2017

Yvette I. Sheline, Tim West, Kevin Yarasheski, Robert Swarm, Mateusz S. Jasielec, Jonathan R. Fisher, Whitney D. Ficker, Ping Yan, Chengjie Xiong, Christine Frederiksen, Monica V. Grzelak, Robert Chott, Randall J. Bateman, John C. Morris, Mark A. Mintun, Jin-Moo Lee and John R. Cirrito: 2014 Sci Transl Med, 10.1126/scitranslmed.3008169 Read More

Posted in: HPAN, Lysosome, Neurodegeneration, Neurogenetics & Transcriptomics, Neurovascular Injury & Repair, Pilot Projects, Publications Faculty: , , ,