News & Publications for:

Nigel Cairns

Functional genomic analyses uncover APOE-mediated regulation of brain and cerebrospinal fluid beta-amyloid levels in Parkinson disease

Posted on November 23, 2020

Laura Ibanez, Jorge A. Bahena, Chengran Yang, Umber Dube, Fabiana H. G. Farias, John P. Budde, Kristy Bergmann, Carol Brenner-Webster, John C. Morris, Richard J. Perrin, Nigel J. Cairns, John O’Donnell, Ignacio Álvarez, Monica Diez-Fairen, Miquel Aguilar, Rebecca Miller, Albert A. Davis, Pau Pastor, Paul Kotzbauer, Meghan C. Campbell, Joel S. Perlmutter, Herve Rhinn, Oscar Harari, Carlos Cruchaga & Bruno A. Benitez. Acta Neuropathologica Communications volume 8, Article number: 196 (2020) Read More

Posted in: Axon Injury & Repair, Clocks & Sleep, HPAN, Lysosome, Neurodegeneration, Neurogenetics & Transcriptomics, Publications Faculty: , , , , , , ,

Soluble amyloid-beta buffering by plaques in Alzheimer disease dementia versus high-pathology controls

Posted on July 20, 2018

Thomas J. Esparza , Mihika Gangolli, Nigel J. Cairns, David L. Brody. PLoS ONE, Volume 13, Issue 7, July 2018, Article number e0200251 Read More

Posted in: HPAN, Neurodegeneration, Publications Faculty:

Genetic variants associated with Alzheimer’s disease confer different cerebral cortex cell-type population structure

Posted on June 21, 2018

Zeran Li, Jorge L. Del-Aguila, Umber Dube, John Budde, Rita Martinez, Kathleen Black, Qingli Xiao, Nigel J. Cairns, The Dominantly Inherited Alzheimer Network (DIAN), Joseph D. Dougherty, Jin-Moo Lee, John C. Morris, Randall J. Bateman, Celeste M. Karch, Carlos Cruchaga, Oscar Harari. Genome Medicine, Volume 10, Issue 1, 8 June 2018, Article number 43 Read More

Posted in: HPAN, Lysosome, Neurodegeneration, Neurogenetics & Transcriptomics, Neurovascular Injury & Repair, Publications Faculty: , , , , , , ,

Preferential degradation of cognitive networks differentiates Alzheimer’s disease from ageing

Posted on May 30, 2018

Jasmeer P Chhatwal Aaron P Schultz Keith A Johnson Trey Hedden Sehily Jaimes Tammie L S Benzinger Clifford Jack, Jr Beau M Ances John M Ringman Daniel S Marcus. Brain, Volume 141, Issue 5, 1 May 2018, Pages 1486-1500 Read More

Posted in: HPAN, Neurodegeneration, Publications Faculty: , , ,

White matter hyperintensities and the mediating role of cerebral amyloid angiopathy in dominantly-inherited Alzheimer’s disease

Posted on May 25, 2018

Seonjoo Lee, Molly E. Zimmerman, Atul Narkhede, Sara E. Nasrabady, Giuseppe Tosto, Irene B. Meier, Tammie L. S. Benzinger, Daniel S. Marcus, Anne M. Fagan, Nick C. Fox, Nigel J. Cairns, David M. Holtzman, Virginia Buckles, [ … ], Dominantly Inherited Alzheimer Network. PLoS ONE, Volume 13, Issue 5, May 2018, Article number e0195838 Read More

Posted in: Clocks & Sleep, HPAN, Neurodegeneration, Neurogenetics & Transcriptomics, Publications Faculty: , , , ,