News & Publications for:

Oscar Harari

A single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brain

Posted on August 23, 2019

Jorge L. Del-Aguila, Zeran Li, Umber Dube, Kathie A. Mihindukulasuriya, John P. Budde, Maria Victoria Fernandez, Laura Ibanez, Joseph Bradley, Fengxian Wang, Kristy Bergmann, Richard Davenport, John C. Morris, David M. Holtzman, Richard J. Perrin, Bruno A. Benitez, Joseph Dougherty, Carlos Cruchaga & Oscar Harari. Alzheimer’s Research and Therapy, Volume 11, Issue 1, 9 August 2019, Article number 71 Read More

Posted in: Clocks & Sleep, HPAN, Lysosome, Neurodegeneration, Neurogenetics & Transcriptomics, Publications Faculty: , , , , ,

The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer’s disease risk

Posted on August 21, 2019

Yuetiva Deming, Fabia Filipello, Francesca Cignarella, Claudia Cantoni, Simon Hsu, Robert Mikesell, Zeran Li, Jorge L Del-Aguila, Umber Dube, Fabiana Geraldo Farias, Joseph Bradley, John Budde, Laura Ibanez, Maria Victoria Fernandez, Kaj Blennow, Henrik Zetterberg, Amanda Heslegrave, Per M Johansson, Johan Svensson, Bengt Nellgård, Alberto Lleo, Daniel Alcolea, Jordi Clarimon, Lorena Rami, José Luis Molinuevo, Marc Suárez-Calvet, Estrella Morenas-Rodríguez, Gernot Kleinberger, Michael Ewers, Oscar Harari, Christian Haass, Thomas J Brett, Bruno A. Benitez, Celeste M. Karch, Laura Piccio and Carlos Cruchaga. Science Translational Medicine, Vol 11, Issue 505,14 August 2019 Read More

Posted in: Axon Injury & Repair, HPAN, Lysosome, Neurodegeneration, Neurogenetics & Transcriptomics, Publications Faculty: , , , ,

TREM2 brain transcript-specific studies in AD and TREM2 mutation carriers

Posted on May 24, 2019

Jorge L. Del-Aguila, Bruno A. Benitez, Zeran Li, Umber Dube, Kathie A. Mihindukulasuriya, John P. Budde, Fabiana H. G. Farias, Maria Victoria Fernández, Laura Ibanez, Shan Jiang, Richard J. Perrin, Nigel J. Cairns, John C. Morris, Oscar Harari and Carlos Cruchaga. Molecular Neurodegeneration, Volume 14, Issue 1, 8 May 2019, Article number 18 Read More

Posted in: HPAN, Lysosome, Neurodegeneration, Neurogenetics & Transcriptomics, Publications Faculty: , , ,

Analysis of whole genome-transcriptomic organization in brain to identify genes associated with alcoholism

Posted on March 1, 2019

Manav Kapoor, Jen-Chyong Wang, Sean P. Farris, Yunlong Liu, Jeanette McClintick, Ishaan Gupta, Jacquelyn L. Meyers, Sarah Bertelsen, Michael Chao, John Nurnberger, Jay Tischfield, Oscar Harari, Li Zeran, Victor Hesselbrock, Lance Bauer, Towfique Raj, Bernice Porjesz, Arpana Agrawal, Tatiana Foroud, Howard J. Edenberg, R. Dayne Mayfield & Alison Goate. Translational Psychiatry, Volume 9, Issue 1, 1 December 2019, Article number 89 Read More

Posted in: Neurogenetics & Transcriptomics, Publications Faculty:

Integrative system biology analyses of CRISPR-edited iPSC-derived neurons and human brains reveal deficiencies of presynaptic signaling in FTLD and PSP

Posted on December 27, 2018

Shan Jiang, Natalie Wen, Zeran Li, Umber Dube, Jorge Del Aguila, John Budde, Rita Martinez, Simon Hsu, Maria V. Fernandez, Nigel J. Cairns, Dominantly Inherited Alzheimer Network (DIAN), International FTD-Genomics Consortium (IFGC), Oscar Harari, Carlos Cruchaga & Celeste M. Karch . Translational Psychiatry, Volume 8, Issue 1, 1 December 2018, Article number 265 Read More

Posted in: Axon Injury & Repair, HPAN, Neurodegeneration, Neurogenetics & Transcriptomics, Pilot Projects, Publications Faculty: , ,