News & Publications for:

Rohit Pappu

Profilin reduces aggregation and phase separation of huntingtin N-terminal fragments by preferentially binding to soluble monomers and oligomers

Posted on March 28, 2018

Ammon E. Posey, Kiersten M. Ruff, Tyler S. Harmon, Scott L. Crick, Aimin Li, Marc I. Diamond and Rohit V. Pappu. Journal of Biological Chemistry, Volume 293, Issue 10, 2018, Pages 3734-3746 Read More

Posted in: HPAN, Neurodegeneration, Publications Faculty: ,

Phase separation of a yeast prion protein promotes cellular fitness

Posted on January 17, 2018

Titus M. Franzmann, […], Rohit V. Pappu, Anthony A. Hyman, Simon Alberti. Science, Volume 359, Issue 6371, 5 January 2018, Article number aao5654 Read More

Posted in: HPAN, Neurodegeneration, Publications Faculty:

Quantitative analysis of multilayer organization of proteins and RNA in nuclear speckles at super resolution

Posted on December 27, 2017

Jingyi Fei, Mahdieh Jadaliha, Tyler S. Harmon, Isaac T. S. Li, Boyang Hua, Qinyu Hao, Alex S. Holehouse, Matthew Reyer, Qinyu Sun, Susan M. Freier, Rohit V. Pappu, Kannanganattu V. Prasanth, Taekjip Ha: Journal of Cell Science, Volume 130, Issue 24, 1 December 2017, Pages 4180-4192 Read More

Posted in: HPAN, Neurodegeneration, Publications Faculty:

Control of transcriptional activity by design of charge patterning in the intrinsically disordered RAM region of the Notch receptor

Posted on November 15, 2017

Kathryn P. Sherrya, Rahul K. Dasb, Rohit V. Pappu, and Doug Barricka: Proceedings of the National Academy of Sciences of the United States of America, Volume 114, Issue 44, 31 October 2017, Pages E9243-E9252 Read More

Posted in: HPAN, Neurodegeneration, Publications Faculty:

Monomeric Huntingtin Exon 1 Has Similar Overall Structural Features for Wild-Type and Pathological Polyglutamine Lengths

Posted on October 31, 2017

John B. Warner IV, Kiersten M. Ruff, Piau Siong Tan, Edward A. Lemke, Rohit V. Pappu, and Hilal A. Lashuel: J. Am. Chem. Soc., 2017, 139 (41), pp 14456–14469 Read More

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