Archives

• September 27, 2021: Hrishikesh Kulkarni (WashU Medicine) “Local complement activation in inflammation and injury”
• October 4, 2021: Hui Zheng (Baylor College of Medicine) “Complement C3 and C3aR signaling in vascular aging and Alzheimer’s disease”
• October 11, 2021: Michael Carroll (Harvard Medical School) “Over expression of schizophrenia susceptibility factor C4A promotes excessive synaptic loss and alteration in behavior”
• November 1, 2021: Robyn Klein (WashU Medicine) “Learning from viruses: Complement and memory”

• November 22, 2021: Timothy Miller (WashU Neurology) “Precision Medicine for ALS”
• November 29, 2021: Aaron DiAntonio (WashU Developmental Biology) “The SARM1 Axon Degeneration Pathway: Implications for ALS pathogenesis and therapy”
• December 6, 2021: Adrian Isaacs (University College London) “Dissecting disease-causing mechanisms in C9orf72 FTD/ALS”
• December 13, 2021: Sami Barmada (University of Michigan) “Dr. Jekyll and Mr. Hyde: The strange case of TDP43 isoforms in ALS and FTD”
• December 20, 2021: Yuna Ayala (Saint Louis University) “What gets TDP-43 into trouble? Understanding the connection between TDP-43 function and ALS pathogenesis”

• January 10, 2022: Sangram Sisodia (University of Chicago) “Role of the Gut Microbiome in the Pathogenesis of Alzheimer’s Disease”
• January 24, 2022: Brian Kim (Icahn School of Medicine at Mount Sinai; formerly WashU Medicine) “Neuroimmune Regulation of Itch”
• January 31, 2022: Beau Ances (WashU Neurology) “The Gut Microbiome in Neurodegenerative Diseases”
• February 7, 2022: John Fryer (Mayo Clinic) “Good bugs gone bad: Bacterial influences on neurological health and disease”
• February 14, 2022: Dong-oh Seo (Holtzman lab, WashU Neurology) “Evidence that the gut microbiota regulates progression of neurodegeneration in a mouse model of tauopathy, in a sex- and ApoE isoform-dependent manner”

• February 21, 2022: Karen O’Malley (WashU Neuroscience) “Location, location, location…site-specific GPCR signaling generates unique functional outcomes”
• February 28, 2022: Talia Lerner (Northwestern University) “Dopamine Circuits Driving the Transition to Habit”
• March 7, 2022:  Jordan McCall (WashU Anesthesiology) “Stress-induced plasticity in noradrenergic analgesia”
• March 14, 2022: Marc Caron (Duke University) “Therapeutic Actions of GPCR Biased Signaling”
• March 21, 2022: Meaghan Creed (WashU Anesthesiology) “Dissecting heterogeneity within the ventral pallidum and its relevance for treating disorders of reward processing”

• March 28, 2022: Bo Chen (Mount Sinai) “Neuroprotective and Regenerative Strategies for Vision Restoration”
• April 4, 2022: Rajendra Apte (WashU Ophthalmology & Visual Sciences) “Metabolism and Retinal Neurodegeneration”
• April 11, 2022: Thomas Reh (University of Washington) “Reprogramming Muller glia for retinal repair: Never too late to change their fate”
• April 18, 2022: Daniel Kerschensteiner (WashU Ophthalmology & Visual Sciences) “Understanding and protecting the human retina”

Kindly note this mini-series is HYBRID. The in-person location is Connor Auditorium (Farrell LTC, Medical Campus).

• May 2, 2022: Alison Snyder-Warwick (WashU Surgery) “Focusing on the motor target: The role of the neuromuscular junction in recovery after nerve injury”
• May 9, 2022: Rejji Kuruvilla (Johns Hopkins University) “Sympathetic nervous system development and functions”
• May 16, 2022: Valeria Cavalli (WashU Neuroscience) “Satellite Glial Cells in sensory nervous system health, injury and disease”
• May 23, 2022: Stefanie Geisler (WashU Neurology) “Chemotherapy-induced neuropathy: From bedside to bench and back”

June 6, 2022: Hope Center Awards Recipients

• Dana Shaw (Mokalled lab, WashU Developmental Biology) “The immune balance necessary for natural spinal cord regeneration”
• Alexandra Litvinchuk (Holtzman lab, WashU Neurology) “The relationship between ApoE4 and lipid accumulation in glia of the P301S mouse model of tauopathy”

• September 21, 2020: Robyn Klein (WashU Medicine) “Virus-mediated diseases of pathological forgetting”
• September 28, 2020: Kenneth Tyler (University of Colorado) “EV-D68 Associated acute flaccid myelitis: A new polio?”
• October 12, 2020: Steven Jacobson (NINDS/NIH) “Association of Human Herpesvirus and Chronic Progressive Neurologic Disease”
• October 19, 2020: Sean Whelan (WashU Molecular Microbiology) “Rabies virus infection of neurons”

• November 9, 2020: Darshan Sapkota (Dougherty lab, WashU Genetics) “Alternative modes of mRNA translation and their neurological significance”
• November 16, 2020: Adrian Krainer (Cold Spring Harbor Laboratory) “From Base Pairs to Bedside: Antisense Modulation of RNA Splicing”
• November 23, 2020: “Data Blitz”
  • Ya-Lin Lu (Yoo lab, WashU Developmental Biology) “Neuronal PTB-mediated alternative splicing of BAF complex subunits”
  • Bryan Copits (WashU Anesthesiology) “Alternative splicing plasticity of synaptic adhesion molecules in human sensory neurons”
  • Brittany Townley (Mosammaparast lab, WashU Pathology & Immunology) “Splicing defects in the pathology of trichothiodystrophy”
• November 30, 2020: Douglas Black (University of California, Los Angeles) “Mechanisms and Programs of Neuronal Gene Regulation by RNA Binding Proteins”
• December 7, 2020: “3R/4R Tau Data Blitz”
  • Lucia Capano (Yoo lab, WashU Developmental Biology) “Using age-maintained, directly-reprogrammed neurons to identify human-specific tau splicing regulators”
  • Miguel Minaya (Karch lab, WashU Psychiatry) “How does 4R-Tau expression affect human iPSC-Neuron maturity?”
  • Lubov Ezerskiy (Miller lab, WashU Neurology) “Increase in 4R tau expression promotes astrocytic dysfunction”

• January 4, 2021: Robyn Klein (WashU Medicine) “BBB crosstalk with T cells determines their CNS entry during health and disease”
• January 11, 2021: Michal Schwartz (Weizmann Institute of Science, Israel) “The immune system holds the key to defeat Alzheimer’s disease”
• January 25, 2021: David Gutmann (WashU Neurology) “T cell regulation of brain tumor formation and growth”
• CANCELLED – February 1, 2021: Gavin Dunn (WashU Neurosurgery) “Identifying and targeting antigens in brain tumors”
• February 8, 2021: Adrian Liston (Babraham Institute, Cambridge) “Using brain Tregs to treat neuroinflammation”

• February 15, 2021: Jonathan Kipnis (WashU Pathology and Immunology) “Glymphatic-lymphatic system in CNS immune surveillance”
• February 22, 2021: David Limbrick, Pat McAllister (WashU Neurosurgery) “Ventricular/subventricular changes in ‘inflammatory’ hydrocephalus”
• March 1, 2021: Geir Ringstad (Oslo University Hospital) “Human CSF dynamics and craniospinal molecular clearance assessed with MRI”
• March 8, 2021: Benjamin Plog (WashU Neurosurgery) “Novel Insight into Regulation of Glymphatic Flow with Implications for Traumatic Brain Injury”
• March 15, 2021: Nathalie Jurisch-Yaksi (Norwegian University of Science and Technology) “Function of motile cilia in brain development and physiology, lesson learned from the zebrafish”

• March 22: Gilbert Gallardo (WashU Neurology) “Engineering Intrabodies that Target Tau for Autophagy mediated degradation”
• March 29: Abhinav Diwan (WashU Medicine) “Lysosomal pathways in Alzheimer’s disease pathogenesis: From matters of the heart to the heart of the matter”
• April 5: Conrad C. Weihl (WashU Neurology) “Autophagy and Selective Autophagy in Neurodegeneration”
• April 12: Steven Finkbeiner (University of California, San Francisco/Gladstone Institutes) “Is the autophagy/lysosomal pathway a common thread for neurodegenerative disease?”

Joint series with the Department of Developmental Biology

• CANCELLED – April 26, 2021: Kelly Botteron (WashU Psychiatry) “Early Brain Development in Trisomy 21: Considerations for Neurodegeneration in the Context of a Neurodevelopmental Disorder”
• May 3, 2021: Beau Ances (WashU Neurology) “Alzheimer Disease in Adults with Down Syndrome”
• May 10, 2021: John Constantino (WashU Psychiatry) “Origins and Management of Psychiatric Complications of Down Syndrome”
• May 17, 2021: Frances Wiseman (University College London) “Understanding Alzheimer’s disease development in the context of Down syndrome; using preclinical models”
• May 24, 2021: Anita Bhattacharyya (University of Wisconsin, Madison) “Modeling neurodevelopment in Down syndrome with iPSCs”

• September 30, 2019: Sheila Stewart (WashU Cell Biology & Physiology) “Age-related stromal changes drive tumorigenesis”
• October 7, 2019: Miranda Orr (Wake Forest University) “Targeting tau-associated cellular senescence to mitigate neurodegeneration and cognitive impairment in age-associated brain diseases”
• October 28, 2019: Darren Baker (Mayo Clinic) “Neurodegenerative Disease Driven by Senescent Cells”
• November 4, 2019: Shin-ichiro Imai (WashU Developmental Biology) “NAD World 3.0: The Inter-Tissue Interactions Mediated by eNAMPT and NMN in Mammalian Aging/Longevity Control”

• November 25, 2019: Joshua Rubin (WashU Pediatrics) “Evolutionary and Developmental Origins of Sex Differences in Biology”
• December 2, 2019: Trainee Talks
  • Jasmin Sponagel (Molecular Cell Biology graduate student, Rubin lab (WashU Pediatrics)) “Sex Differences in Redox State Underlie Glutamine Dependency in Male Glioblastoma”
  • Lauren Broestl (MSTP student, Rubin Lab (WashU Pediatrics)) “Astrocyte Senescence Contributes to Sex Differences in Glioblastoma Incidence and Outcome”
  • Nathan Rockwell (Molecular Cell Biology graduate student, Rubin lab (WashU Pediatrics)) “Investigating sex differences in p53 gain-of-function mutations in glioblastoma”
  • Sarah Rosen (Posdoctoral Research Scholar, Klein lab (WashU Medicine)) “Sexually Dimorphic Immune Responses to Neuroinvasive West Nile Virus”
• December 9, 2019: Manu Goyal (WashU Radiology) “Sex differences in human metabolic brain aging”, Joseph Ippolito (WashU Radiology) “Metabolism-driven sex differences in cancer outcomes: implications for diet and obesity”
• December 16, 2019: John Constantino (WashU Psychiatry) “Closing in on the Cause(s) of the Pronounced Sex Ratio in Autism”, Joseph Dougherty (WashU Genetics) “A model for gene-based and sex-based risk in psychiatric disease”

• January 6, 2020: Ana Maria Arbelaez (WashU Pediatrics)
• January 13, 2020: Brian Gordon (WashU Radiology) “Multimodal imaging in disease”
• January 27, 2020: William Kreisl (Columbia University) “”What can PET imaging of translocator protein 18 kDa (TSPO) teach us about Alzheimer’s disease?””
• February 3, 2020: Joel Perlmutter (WashU Neurology) “Neuroimaging biomarkers of parkinsonism”

Joint series with the Department of Neurology and the Center for Science and Engineering of Living Systems (CSELS)

• February 10, 2020: Carlos Castañeda (Syracuse University)“Protein droplets and ALS: Liquid-liquid phase separation of UBQLN2 is modulated by oligomerization, ALS-linked mutations, and ubiquitin binding”
• February 24, 2020: Alex Holehouse (WashU Biochemistry and Molecular Biophysics) “The physical basis for phase separation of intrinsically disordered proteins”
• March 2, 2020: Rohit Pappu (WashU Biomedical Engineering) “Phase separation of multivalent proteins implicated in neurodegeneration”
• CANCELLED – March 9, 2020: James Shorter (University of Pennsylvania) “Combating deleterious phases in ALS/FTD”

Due to the 2020 Covid-19 pandemic the following Hope Center/Neurology Monday Noon Seminars were cancelled.

• March 23, 2020: Steven Finkbeiner (University of California, San Francisco/Gladstone Institute)
• March 30, 2020: Conrad C. Weihl (WashU Neurology)
• April 6, 2020: Gilbert Gallardo (WashU Neurology)
• April 13, 2020: Abhinav Diwan (WashU Medicine)

Joint series with the Department of Developmental Biology

Due to the 2020 Covid-19 pandemic the following Hope Center/Neurology Monday Noon Seminars were cancelled.

• April 20, 2020
• May 4, 2020: Paschalis Kratsios (University of Chicago)
• May 11, 2020: Mayssa Mokalled (WashU Developmental Biology)
• May 18, 2020

• September 24, 2018: Eric Wang (University of Florida) “The double life of RNA binding proteins in muscle and the central nervous system – implications for Myotonic Dystrophy”
• October 1, 2018: Sebla Kutluay (WashU Molecular Microbiology) “Unexpected Roles of RNA-binding Proteins in HIV-1 Replication”
• October 8, 2018: Brian Clark (WashU Ophthalmology & Visual Sciences) “Comprehensive Analysis of Retinal Development at single-cell resolution”
• October 15, 2018: Sergej Djuranovic (WashU Cell Biology & Physiology) “mRNA sequence determinants of the efficient protein synthesis”

• November 19, 2018: Amy Licis (WashU Neurology) “Sleep disturbances in Wolfram syndrome”  
• November 26, 2018: Erik Herzog (WashU Biology) “Clock cartography: Mapping circadian connections and dysfunctions”
• December 3, 2018: Yo-El Ju (WashU Neurology) “Sleep and amyloid-beta”
• December 10, 2018: Jon Willie (Emory University) “Deep Brain Stimulation: Hope for Narcolepsy with Cataplexy?”

• January 7, 2019: Brad Racette (WashU Neurology) “Human Environmental Mn Exposure as a Model of Neurodegeneration”
• January 14, 2019: Joseph Bloom (WashU Psychiatry) “Genetic and environmental factors influencing nicotine metabolism and dependence”
• CANCELLED January 28, 2019: Jordan McCall (WashU Anesthesiology) “The maternal and homecage environments as important drivers of neural circuit dysfunction”
• February 4, 2019: Patricia Jensen (NIH/National Institute of Environmental Health Sciences) “Genetic approaches toward defining noradrenergic neuron diversity”

• February 18, 2019: Jin-Moo Lee (WashU Neurology) “Plasticizing the Cortex to Enhance Stroke Recovery”
• February 25, 2019: Gregory Zipfel (WashU Neurosurgery) “The Promise of Conditioning-Based Therapy for Aneurysmal Subarachnoid Hemorrhage”
• March 4, 2019: S. Thomas Carmichael (University of California, Los Angeles) “Neural Repair after Stroke: Smart Mice to Smart Humans”
• March 11, 2019: Nico Dosenbach (WashU Neurology) “Precision Functional Mapping of Individual Brains”

• March 25, 2019: Gwendalyn Randolph (WashU Pathology & Immunology) “Lipoprotein trafficking through the interstitium and lymphatics in chronic inflammatory disease”
• April 1, 2019: Suzanne Pfeffer (Stanford University) “Cholesterol and membrane trafficking: implications for Niemann Pick Type C and familial Parkinson’s disease”
• April 8, 2019: Douglas Covey (WashU Developmental Biology) “Click chemistry for studies of cholesterol, oxysterol and neurosteroid biology”
• April 15, 2019: Jonathan Cooper (WashU Pediatrics) “The same, but different. New lessons about Batten disease”

Joint series with the Department of Developmental Biology

• April 22, 2019: Aaron DiAntonio (WashU Developmental Biology) “Axon Degeneration: Mechanistic Insights Yield New Therapeutic Strategies for Neurodegenerative Diseases”
• April 29, 2019: Albert Kim (WashU Neurosurgery) “Maintenance and modeling of glioblastoma stem-like cells”
• May 13, 2019: Celeste Karch (WashU Psychiatry) “Modeling tauoapthies in human stem cells”
• May 20, 2019: Justin Ichida (University of Southern California) “Using Cellular Reprogramming to Identify New Therapeutic Targets for Neurodegenerative Diseases”

• October 22, 2018: Ronald Cohn (Fluidigm), Stephen Oh (WashU Medicine) “Hyperion Imaging System”
• November 12, 2018: Leonard Petrucelli (Mayo Clinic) “Mechanistic and Therapeutic Insights into c9orf72 FTD/ALS”*BJC Investigator Program Seminar co-hosted by the Department of Neurology and Department of Neuroscience
• March 1, 2019: Heather Rice (KU Leuven, Belgium) “A novel role for Alzheimer’s Amyloid Precursor Protein in GABAergic signaling”
• March 18, 2019: State of the Hope Center
  • Hiroko Yano (WashU Neurosurgery) “The role of DNA methylation in Huntington’s disease”
  • Celeste Karch (WashU Psychiatry)“Neuronal subtype-specific vulnerability in tauopathies using human stem cells”
• June 10, 2019: Winners, Hope Center Awards – NOTE This seminar will be held in BJC Institute of Health 9AB.
  • Andrew Findlay (Weihl Lab, Neurology)
    “Therapeutic modulation of chaperone functions in LGMD1D”
  • Zachary Rosenthal (Lee Lab, Neurology)
    “Local perturbations in cortical excitability propagate differentially through large-scale functional networks”

• October 30, 2017: Beau Ances (WashU Neurology) “Imaging of Microglia using PET and MRI”
• November 6, 2017: Tyler Ulland (Colonna Lab, WashU Pathology & Immunology) “Trem2: key to microglial fitness in Alzheimer’s disease”
• November 27, 2017: Robyn Klein (WashU Medicine) “Glia Reprogram Brain Function During WNV Encephalitis”
• December 4, 2017: Joseph Dougherty (WashU Genetics) “Astrocyte alternative translation and neurological disease”
• December 11, 2017: Erik Musiek (WashU Neurology) “Circadian regulation of neuroinflammation”
• December 18, 2017: Kim Green (University of California, Irvine) “Exploring the roles of microglia in the pathogenesis of Alzheimer’s disease”

• January 8, 2018: Julia Lemos (University of Minnesota) “Restructuring of basal ganglia circuitry and associated behaviors triggered by low striatal D2 receptor expression: implications for substance use disorders”
• January 22, 2018: Jose Moron-Concepcion (WashU Anesthesiology) “Opioid-induced plasticity and the intersection with pain”
• CANCELLED January 29, 2018: Ream Al-Hasani (St. Louis College of Pharmacy/WashU Anesthesiology)  “Dissecting endogenous opioid systems in motivated behaviors”
• February 5, 2018: Ilya Monosov (WashU Dept. of Neuroscience) “Why would you want to know? Brain networks for uncertainty reduction”

• February 19, 2018: Larissa Thackray (WashU Medicine) “The Role of the Gut Microbiota in Neurotropic Flavivirus Infection”
• February 26, 2018: Barbara Warner (WashU Pediatrics) “The Gut Microbiome Contribution to Neurodevelopment and Neuropsychiatric Disorders”
• March 5, 2018: Yanjiao Zhou (The Jackson Laboratory), Laura Piccio (WashU Neurology) “Intermittent fasting and gut microbiome in CNS autoimmunity”
• March 12, 2018: Barbara Bendlin (University of Wisconsin) “From fringe to foreground: do microbes play a role in Alzheimer’s?”

• March 19, 2018: Timothy Miller (WashU Neurology) “ALS and Frontotemporal Dementia” 
• March 26, 2018: Yuna Ayala (Saint Louis University) “Walking the tightrope: an emerging role of RNA binding proteins in ALS and FTD”
• April 9, 2018:  Clotilde Lagier-Tourenne (Harvard Medical School) “Modeling C9ORF72 disease: a crucial step for therapeutic development in ALS/FTD”
• April 16, 2018: Meredith Jackrel (WashU Chemistry) “Protein disaggregases to counter TDP-43, FUS, DPR, and SOD1 misfolding implicated in ALS”

Joint series with the Department of Developmental Biology

• April 30, 2018: Fumihiko Urano (WashU Medicine) “Precision Medicine for Endoplasmic Reticulum Disease”
• May 7, 2018: Erik Musiek (WashU Neurology) “Differential regulation of amyloid-beta and tau by the circadian clock”
• May 14, 2018: Shin-Ichiro Imai (WashU Developmental Biology) “Achieving Productive Aging Based on the NAD World 2.0: The Importance of eNAMPT and the NMN Transporter”
• May 21, 2018: Anne Bertolotti (MRC Laboratory of Molecular Biology, UK) “Boosting protein quality control to prevent neurodegenerative diseases”

• October 2, 2017: Vikram Shakkottai (University of Michigan Medicine), “Targeting neuronal dysfunction in cerebellar ataxia”
• November 20, 2017: David Holtzman, “State of the Hope Center”
• June 4, 2018: Winners, Hope Center Awards
  • Scott Karney-Grobe (DiAntonio Lab, Developmental Biology) “HSP90 is a chaperone for DLK and is required for axon injury signaling”
  • Alex Cammack (Miller Lab, Neurology) “C9orf72 G₄C₂ repeat expansions in ALS patients are dynamic and result in large dipeptide repeat proteins”