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Pilot Projects

An antidepressant decreases CSF Aβ production in healthy individuals and in transgenic AD mice

Posted on June 28, 2017

Yvette I. Sheline, Tim West, Kevin Yarasheski, Robert Swarm, Mateusz S. Jasielec, Jonathan R. Fisher, Whitney D. Ficker, Ping Yan, Chengjie Xiong, Christine Frederiksen, Monica V. Grzelak, Robert Chott, Randall J. Bateman, John C. Morris, Mark A. Mintun, Jin-Moo Lee and John R. Cirrito: 2014 Sci Transl Med, 10.1126/scitranslmed.3008169 Read More

Posted in: HPAN, Lysosome, Neurodegeneration, Neurogenetics & Transcriptomics, Neurovascular Injury & Repair, Pilot Projects, Publications Faculty: , , ,

A sensitive assay reveals structural requirements for α-synuclein fibril growth

Posted on June 28, 2017

Dhruva D. Dhavale, Christina Tsai, Devika P. Bagchi, Laura A. Engel, Jonathan Sarezky and Paul T. Kotzbauer: 2017 J Biol Chem.; 292(22):9034-9050. Read More

Posted in: HPAN, Neurodegeneration, Pilot Projects, Publications Faculty:

MicroRNA profiling reveals marker of motor neuron disease in ALS models

Posted on June 28, 2017

Mariah L. Hoye, Erica D. Koval, Amy J. Wegener, Theodore S. Hyman, Chengran Yang, David R. O’Brien, Rebecca L. Miller, Tracy Cole, Kathleen M. Schoch, Tao Shen, Tomonori Kunikata, Jean-Philippe Richard, David H. Gutmann, Nicholas J. Maragakis, Holly B. Kordasiewicz, Joseph D. Dougherty and Timothy M. Miller: 2017 Journal of Neuroscience, 37 (22) 5574-5586 Read More

Posted in: HPAN, Neurodegeneration, Neurogenetics & Transcriptomics, NeuroRestorative Therapy, Pilot Projects, Publications Faculty: , ,

An evolutionarily conserved mechanism for cAMP elicited axonal regeneration involves direct activation of the DLK kinase

Posted on June 10, 2016

Yan Hao, Erin Frey, Choya Yoon Hetty Wong, Douglas Nestorovski, Lawrence B Holzman, Roman J Giger, Aaron DiAntonio, Catherine Collins: 2016 eLife 5:e14048. PMC4896747 Read More

Posted in: Axon Injury & Repair, Pilot Projects, Publications Faculty:

A Comprehensive Analysis of Cell Type-Specific Nuclear RNA From Neurons and Glia of the Brain

Posted on May 23, 2016

Adarsh S. Reddy, David O’Brien, Nilambari Pisat, Claire T. Weichselbaum, Kristina Sakers, Miriam Lisci, Jasbir S. Dalal, Joseph D. Dougherty: 2017 Biological Psychiatry Volume 81, Issue 3, Pages 252–264 Read More

Posted in: Neurogenetics, Pilot Projects, Publications Faculty: