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A murine Niemann-Pick C1 (NPC1) I1061T knockin model recapitulates the pathological features of the most prevalent human disease allele

Posted on October 20, 2016

Praggastis M, Tortelli B, Zhang J, Fujiwara H, Sidhu R, Chacko A, Chen Z, Lieberman AP, Davidson C, Walkley SU, Pipalia NH, Maxfield FR, Schaffer JE, and Ory DS: 2015 J Neuroscience, 35:8091-8106. PMCID: PMC4444535 Read More

Posted in: HPAN, Lysosome, Neurodegeneration, Publications Faculty:

Imaging and cerebrospinal fluid biomarkers in early preclinical alzheimer disease

Posted on September 30, 2016

Vlassenko AG, McCue L, Jasielec MS, et al: 2016 Annals of Neurology, 80(3), pp 379-387 Read More

Posted in: Clocks & Sleep, HPAN, Neurodegeneration, Publications Faculty: , , ,

Posted on September 22, 2016

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Posted in: HPAN, Neurodegeneration, News Faculty:

Inhibition of DNA methyltransferases blocks mutant huntingtin-induced neurotoxicity

Posted on August 31, 2016

Pan Y, Daito T, Sasaki Y, et al: 2016 Sci Rep doi: 10.1038/srep31022 Read More

Posted in: HPAN, Neurodegeneration, NeuroRestorative Therapy, Publications Faculty: ,