The latest published manuscripts and reviews from Hope Center investigators, and publications based on use of Hope Center Cores. Click on titles to learn more. Read More

An antidepressant decreases CSF Aβ production in healthy individuals and in transgenic AD mice

Posted on June 28, 2017

Yvette I. Sheline, Tim West, Kevin Yarasheski, Robert Swarm, Mateusz S. Jasielec, Jonathan R. Fisher, Whitney D. Ficker, Ping Yan, Chengjie Xiong, Christine Frederiksen, Monica V. Grzelak, Robert Chott, Randall J. Bateman, John C. Morris, Mark A. Mintun, Jin-Moo Lee and John R. Cirrito: 2014 Sci Transl Med, 10.1126/scitranslmed.3008169 Read More

Posted in: HPAN, Lysosome, Neurodegeneration, Neurogenetics & Transcriptomics, Neurovascular Injury & Repair, Pilot Projects, Publications Faculty: , , ,

A sensitive assay reveals structural requirements for α-synuclein fibril growth

Posted on June 28, 2017

Dhruva D. Dhavale, Christina Tsai, Devika P. Bagchi, Laura A. Engel, Jonathan Sarezky and Paul T. Kotzbauer: 2017 J Biol Chem.; 292(22):9034-9050. Read More

Posted in: HPAN, Neurodegeneration, Pilot Projects, Publications Faculty:

MicroRNA profiling reveals marker of motor neuron disease in ALS models

Posted on June 28, 2017

Mariah L. Hoye, Erica D. Koval, Amy J. Wegener, Theodore S. Hyman, Chengran Yang, David R. O’Brien, Rebecca L. Miller, Tracy Cole, Kathleen M. Schoch, Tao Shen, Tomonori Kunikata, Jean-Philippe Richard, David H. Gutmann, Nicholas J. Maragakis, Holly B. Kordasiewicz, Joseph D. Dougherty and Timothy M. Miller: 2017 Journal of Neuroscience, 37 (22) 5574-5586 Read More

Posted in: HPAN, Neurodegeneration, Neurogenetics & Transcriptomics, NeuroRestorative Therapy, Pilot Projects, Publications Faculty: , ,

Oligodendroglial myelination requires astrocyte-derived lipids

Posted on June 28, 2017

Nutabi Camargo , Andrea Goudriaan , Anne-Lieke F. van Deijk, Willem M. Otte, Jos F. Brouwers, Hans Lodder, David H. Gutmann, Klaus-Armin Nave, Rick M. Dijkhuizen, Huibert D. Mansvelder, Roman Chrast, August B. Smit, Mark H. G. Verheijen: 2017 PLoS Biology Volume 15, Issue 5, Article number e1002605 Read More

Posted in: Neurogenetics & Transcriptomics, Publications Faculty: