News & Publications for:

Alex Evers

Common binding sites for cholesterol and neurosteroids on a pentameric ligand-gated ion channel

Posted on December 10, 2018

Melissa M. Budelier, Wayland W.L. Cheng, Zi-Wei Chen, John R. Bracamontes, Yusuke Sugasawa, Kathiresan Krishnan, Laurel Mydock-McGrane, Douglas F. Covey, Alex S. Evers. Biochimica et Biophysica Acta – Molecular and Cell Biology of Lipids, Volume 1864, Issue 2, February 2019, Pages 128-136 Read More

Posted in: Axon Injury & Repair, Publications Faculty:

Enhanced GABAergic actions resulting from the coapplication of the steroid 3α-hydroxy-5α-pregnane-11,20-dione (alfaxalone) with propofol or diazepam

Posted on August 6, 2018

Lily Q. Cao, Michael C. Montana, Allison L. Germann, Daniel J. Shin, Sampurna Chakrabarti, Steven Mennerick, Carla M. Yuede, David F. Wozniak, Alex S. Evers & Gustav Akk. Scientific Reports, Volume 8, Issue 1, 1 December 2018, Article number 10341 Read More

Posted in: Axon Injury & Repair, HPAN, Neurodegeneration, Publications Faculty: , ,

High constitutive activity accounts for the combination of enhanced direct activation and reduced potentiation in mutated GABAA receptors

Posted on April 18, 2018

Allison L. Germann, Daniel J. Shin, Christina R. Kuhrau, Alexander D. Johnson, Alex S. Evers and Gustav Akk. Molecular Pharmacology, Volume 93, Issue 5, May 2018, Pages 468-476 Read More

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Propofol discovery may aid development of new anesthetics

Posted on September 26, 2013

From the WUSTL Newsroom… Researchers at Washington University School of Medicine in St. Louis and Imperial College London have identified the site where the widely used anesthetic drug propofol binds to receptors in the brain to sedate patients during surgery. Until now, it hasn’t been clear how propofol connects with brain cells to induce anesthesia. The researchers believe the findings, reported online in the journal Nature Chemical Biology, eventually will lead to the development of more effective … Read More Read More

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Preventing memory of surgery

Posted on February 14, 2012

Alex Evers and colleagues show that FDA-approved device does not lower risk of intraoperative awareness compared to less costly method. Read More

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