News & Publications for:

Carlos Cruchaga

Integrative system biology analyses of CRISPR-edited iPSC-derived neurons and human brains reveal deficiencies of presynaptic signaling in FTLD and PSP

Posted on December 27, 2018

Shan Jiang, Natalie Wen, Zeran Li, Umber Dube, Jorge Del Aguila, John Budde, Rita Martinez, Simon Hsu, Maria V. Fernandez, Nigel J. Cairns, Dominantly Inherited Alzheimer Network (DIAN), International FTD-Genomics Consortium (IFGC), Oscar Harari, Carlos Cruchaga & Celeste M. Karch . Translational Psychiatry, Volume 8, Issue 1, 1 December 2018, Article number 265 Read More

Posted in: Axon Injury & Repair, HPAN, Neurodegeneration, Neurogenetics & Transcriptomics, Pilot Projects, Publications Faculty: , ,

Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia

Posted on December 17, 2018

Vivek Swarup, Flora I. Hinz, Jessica E. Rexach, Ken-ichi Noguchi, Hiroyoshi Toyoshiba, Akira Oda, Keisuke Hirai, Arjun Sarkar, Nicholas T. Seyfried, Chialin Cheng, Stephen J. Haggarty, International Frontotemporal Dementia Genomics Consortium, Murray Grossman, Vivianna M. Van Deerlin, John Q. Trojanowski, James J. Lah, Allan I. Levey, Shinichi Kondou & Daniel H. Geschwind. Nature Medicine 2018 Read More

Posted in: HPAN, Lysosome, Neurodegeneration, Neurogenetics & Transcriptomics Faculty:

Effect of apolipoprotein E4 on clinical, neuroimaging, and biomarker measures in noncarrier participants in the Dominantly Inherited Alzheimer Network

Posted on December 13, 2018

Aurélie Bussy, Joy Snider, Dean Coble, Chengjie Xiong, Anne M. Fagan, Carlos Cruchaga, Tammie L.S. Benzinger, Brian A. Gordon, Jason Hassenstab, Randall J. Bateman, John C. Morris, the Dominantly Inherited Alzheimer Network. Neurobiology of Aging, Volume 75, March 2019, Pages 42-50 Read More

Posted in: HPAN, Lysosome, Neurogenetics & Transcriptomics, Publications Faculty: , , , , ,

CSF progranulin increases in the course of Alzheimer’s disease and is associated with sTREM2, neurodegeneration and cognitive decline

Posted on December 6, 2018

Marc Suárez‐Calvet, Anja Capell, Miguel Ángel Araque Caballero, Estrella Morenas‐Rodríguez, Katrin Fellerer, Nicolai Franzmeier, Gernot Kleinberger, Erden Eren, Yuetiva Deming, Laura Piccio, Celeste M Karch, Carlos Cruchaga, Katrina Paumier, Randall J Bateman, Anne M Fagan, John C Morris, Johannes Levin, Adrian Danek, Mathias Jucker, Colin L Masters, Martin N Rossor, John M Ringman, Leslie M Shaw, John Q Trojanowski, Michael Weiner, Michael Ewers, Christian Haass, the Dominantly Inherited Alzheimer Network, the Alzheimer’s Disease Neuroimaging Initiative. EMBO Molecular Medicine, 2018, Article number e9712 Read More

Posted in: Axon Injury & Repair, HPAN, Neurodegeneration, Neurogenetics & Transcriptomics, Publications Faculty: , , , , ,

Genome-wide association study of brain amyloid deposition as measured by Pittsburgh Compound-B (PiB)-PET imaging

Posted on November 12, 2018

Qi Yan, Kwangsik Nho, Jorge L. Del-Aguila, Xingbin Wang, Shannon L. Risacher, Kang-Hsien Fan, Beth E. Snitz, Howard J. Aizenstein, Chester A. Mathis, Oscar L. Lopez, F. Yesim Demirci, Eleanor Feingold, William E. Klunk, Andrew J. Saykin, for the Alzheimer’s Disease Neuroimaging Initiative (ADNI), Carlos Cruchaga & M. Ilyas Kamboh . Molecular Psychiatry 2018 Read More

Posted in: HPAN, Neurodegeneration, Neurogenetics & Transcriptomics, Publications Faculty: