News & Publications for:

Charles Zorumski

New target explored for psychiatric drug development

Posted on February 19, 2014

From the WUSTL Newsroom… In a surprising discovery, neuroscientists have found that a breakdown product of cholesterol in the brain may be a target for developing new drugs to treat schizophrenia and other mental illnesses. Although the research is in its early stages, the finding comes at a crucial time. Most existing drugs to treat schizophrenia work in similar ways, targeting dopamine receptors in the brain, but many patients don’t respond well to the medications or … Read More

Posted in: Axon Injury & Repair Faculty:

The major brain cholesterol metabolite 24(S)-hydroxycholesterol is a potent allosteric modulator of N-Methyl-D-Aspartate receptors

Posted on November 18, 2013

Paul SM, Doherty JJ, Robichaud AJ, Belfort GM, Chow BY, Hammond RS, Crawford DC, Linsenbardt AJ, Shu H-J, Isumi Y, Mennerick SJ, Zorumski CF; (2013) Journal of Neuroscience, 33 (44), pp. 17290-17300. Read More

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