News & Publications for:

David Holtzman

White matter hyperintensities and the mediating role of cerebral amyloid angiopathy in dominantly-inherited Alzheimer’s disease

Posted on May 25, 2018

Seonjoo Lee, Molly E. Zimmerman, Atul Narkhede, Sara E. Nasrabady, Giuseppe Tosto, Irene B. Meier, Tammie L. S. Benzinger, Daniel S. Marcus, Anne M. Fagan, Nick C. Fox, Nigel J. Cairns, David M. Holtzman, Virginia Buckles, [ … ], Dominantly Inherited Alzheimer Network. PLoS ONE, Volume 13, Issue 5, May 2018, Article number e0195838 Read More

Posted in: Clocks & Sleep, HPAN, Neurodegeneration, Neurogenetics & Transcriptomics, Publications Faculty: , , , ,

Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation

Posted on May 17, 2018

Fan Liao, … and David M. Holtzman. Journal of Clinical Investigation, Volume 128, Issue 5, 1 May 2018, Pages 2144-2155 Read More

Posted in: Clocks & Sleep, HPAN, Neurodegeneration, Publications Faculty:

ApoE facilitates the microglial response to amyloid plaque pathology

Posted on April 14, 2018

Jason D. Ulrich, Tyler K. Ulland, Thomas E. Mahan, Sofie Nyström, K. Peter Nilsson, Wilbur M. Song, Yingyue Zhou, Mariska Reinartz, Seulah Choi, Hong Jiang, Floy R. Stewart, Elise Anderson, Yaming Wang, Marco Colonna, David M. Holtzman . Journal of Experimental Medicine, Volume 215, Issue 4, 1 April 2018, Pages 1047-1058 Read More

Posted in: Clocks & Sleep, HPAN, Neurodegeneration, Neurogenetics & Transcriptomics, Publications Faculty: ,

Antibody removes Alzheimer’s plaques, in mice

Posted on March 27, 2018

Potential therapy removes APOE and plaques from brain Read More

Posted in: Clocks & Sleep, HPAN, Neurodegeneration, News Faculty:

Behavioral and transcriptomic analysis of Trem2-null mice: Not all knockout mice are created equal

Posted on March 3, 2018

Silvia S Kang, Aishe Kurti, Kelsey E Baker, Chia-Chen Liu, Marco Colonna, Jason D Ulrich, David M Holtzman, Guojun Bu, John D Fryer. Human Molecular Genetics, Volume 27, Issue 2, 15 January 2018, Pages 211-223 Read More

Posted in: HPAN, Neurodegeneration, Neurogenetics & Transcriptomics, Publications Faculty: ,