News & Publications for:

David Holtzman

Lack of BACE1 S-palmitoylation reduces amyloid burden and mitigates memory deficits in transgenic mouse models of Alzheimer’s disease

Posted on September 30, 2017

Robert J. Andrewa, […], David M. Holtzman and Gopal Thinakaran: Proceedings of the National Academy of Sciences of the United States of America, Volume 114, Issue 45, 7 November 2017, Pages E9665-E9674 Read More

Posted in: Clocks & Sleep, HPAN, Neurodegeneration, Publications Faculty:

Slow wave sleep disruption increases cerebrospinal fluid amyloid-β levels

Posted on September 7, 2017

Yo-El S. Ju, Sharon J. Ooms, Courtney Sutphen, Shannon L. Macauley, Margaret A. Zangrilli, Gina Jerome, Anne M. Fagan, Emmanuel Mignot, John M. Zempel, Jurgen A.H.R. Claassen, David M. Holtzman: 2017 Brain, Volume 140, Issue 8, Pages 2104–2111 Read More

Posted in: Clocks & Sleep, HPAN, Neurodegeneration, Publications Faculty: , ,

Amyloid β concentrations and stable isotope labeling kinetics of human plasma specific to central nervous system amyloidosis

Posted on August 11, 2017

Vitaliy Ovod, Kara N. Ramsey, Kwasi G. Mawuenyega, Jim G. Bollinger, Terry Hicks, Theresa Schneider, Melissa Sullivan, Katrina Paumier, David M. Holtzman, John C. Morris, Tammie Benzinger, .Anne M. Fagan, Bruce W. Patterson, Randall J. Bateman: 2017 Alzheimer’s and Dementia Volume 13, Issue 8, Pages 841-849 Read More

Posted in: Clocks & Sleep, HPAN, Neurodegeneration, Neurogenetics & Transcriptomics, Publications Faculty: , , ,

TREM2 Maintains Microglial Metabolic Fitness in Alzheimer’s Disease

Posted on August 11, 2017

Tyler K. Ulland, Wilbur M. Song, Stanley Ching-Cheng Huang, Jason D. Ulrich, Alexey Sergushichev, Wandy L. Beatty, Alexander A. Loboda, Yingyue Zhou, Nigel J. Cairns, Amal Kambal, Ekaterina Loginicheva, Susan Gilfillan, Marina Cella, Herbert W. Virgin, Emil R. Unanue, Yaming Wang, Maxim N. Artyomov, David M. Holtzman, Marco Colonna: 2017 Cell Volume 170, Issue 4, p649–663.e13 Read More

Posted in: Axon Injury & Repair, Clocks & Sleep, HPAN, Neurodegeneration, Neurogenetics & Transcriptomics, Publications Faculty: , , ,