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Hiroko Yano

Fatal cell malfunction ID’d in Huntington’s disease

Posted on June 27, 2014

From the WUSTL Newsroom… Researchers believe they have learned how mutations in the gene that causes Huntington’s disease kill brain cells, a finding that could open new opportunities for treating the fatal disorder. Scientists first linked the gene to the inherited disease more than 20 years ago. Huntington’s disease affects five to seven people out of every 100,000. Symptoms, which typically begin in middle age, include involuntary jerking movements, disrupted coordination and cognitive problems such as … Read More Read More

Posted in: HPAN, Neurodegeneration, News Faculty: ,

Inhibition of mitochondrial protein import by mutant huntingtin

Posted on June 17, 2014

Abstract Mitochondrial dysfunction is associated with neuronal loss in Huntington’s disease (HD), a neurodegenerative disease caused by an abnormal polyglutamine expansion in huntingtin (Htt). However, the mechanisms linking mutant Htt and mitochondrial dysfunction in HD remain unknown. We identify an interaction between mutant Htt and the TIM23 mitochondrial protein import complex. Remarkably, recombinant mutant Htt directly inhibited mitochondrial protein import in vitro. Furthermore, mitochondria from brain synaptosomes of presymptomatic HD model mice and from mutant … Read More Read More

Posted in: HPAN, Neurodegeneration, Neurogenetics Faculty: ,

The melatonin-MT1 receptor axis modulates mutant huntingtin-mediated toxicity

Posted on April 30, 2011

Wang X, Sirianni A, Pei Z, Cormier K, Smith K, Jiang J, Zhou S, Wang H, Zhao R, Yano H, Kim JE, Li W, Kristal BS, Ferrante RJ, Friedlander RM (2011). J Neurosci, 31(41):14496-507 Read More

Posted in: Neurodegeneration, Publications Faculty:

Proneurotrophin-3 is a neuronal apoptotic ligand: evidence for retrograde-directed cell killing

Posted on April 30, 2009

Yano H, Torkin R, Martin LA, Chao MV, Teng KK (2009). J Neurosci, 29(47):14790-802 Read More

Posted in: Neurodegeneration, Publications Faculty:

BDNF-mediated neurotransmission relies upon a myosin VI motor complex

Posted on April 30, 2006

Yano H, Ninan I, Zhang H, Milner TA, Arancio O, Chao MV (2006). Nat Neurosci, 9(8):1009-18 Read More

Posted in: Neurodegeneration, Publications Faculty: