News & Publications for:

John Cirrito

TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques

Posted on May 31, 2016

Wang Y, Ulland TK, Ullrich JD, et al: 2016 Journal of Experimental Medicine, 213(5), pp 667-675 Read More

Posted in: Axon Injury & Repair, Clocks & Sleep, HPAN, Neurodegeneration, Publications Faculty: , ,

A spectrum of exercise training reduces soluble Aβ in a dose-dependent manner in a mouse model of Alzheimer’s disease

Posted on January 14, 2016

Moore, KM, Girens, RE, Larson, SK, et. al: 2016 Neurobiology of Disease, vol85, pp218-224 Read More

Posted in: Clocks & Sleep, HPAN, Neurodegeneration, Publications Faculty: ,

Neuronal-Targeted TFEB Accelerates Lysosomal Degradation of APP, Reducing Aβ Generation and Amyloid Plaque Pathogenesis

Posted on September 2, 2015

Qingli Xiao, Ping Yan, Xiucui Ma, Haiyan Liu, Ronaldo Perez, Alec Zhu, Ernesto Gonzales, Danielle L. Tripoli, Leah Czerniewski, Andrea Ballabio, John R. Cirrito, Abhinav Diwan and Jin-Moo Lee: 2015 J Neurosci ;35(35):12137-51. Read More

Posted in: HPAN, Lysosome, Neurodegeneration, Neurogenetics & Transcriptomics, Neurovascular Injury & Repair, Pilot Projects, Publications Faculty: , ,

TREM2 lipid sensing sustains the microglial response in an Alzheimer’s disease model

Posted on April 9, 2015

Wang Y, Cella M, Mallinson K, et al: 2015 Cell, 160(6), pp 1061-1071 Read More

Posted in: Clocks & Sleep, HPAN, Neurodegeneration, Publications Faculty: ,