News & Publications for:

John Cirrito

Serotonin signaling is associated with lower amyloid-beta levels and plaques in transgenic mice and humans

Posted on October 6, 2011

Cirrito JR, Disabato BM, Restivo JL, Verges DK, Goebel WD, Sathyan A, Hayreh D, D’Angelo G, Benzinger T, Yoon H, Kim J, Morris JC, Mintun MA, Sheline YI (2011). Proc Natl Acad Sci USA, 108(36):14968-73 Read More

Posted in: HPAN, Neurodegeneration, Pilot Projects, Publications, Therapeutics & Diagnostics Faculty: , ,

Opposing synaptic regulation of amyloid-beta metabolism by NMDA receptors in vivo

Posted on October 6, 2011

Verges DK, Restivo JL, Goebel WD, Holtzman DM, Cirrito JR (2011). J Neurosci, 31(31):11328-37 Read More

Posted in: HPAN, Neurodegeneration, Publications, Therapeutics & Diagnostics Faculty: ,

Characterizing the appearance and growth of amyloid plaques in APP/PS1 mice

Posted on October 12, 2009

Yan P, Bero AW, Cirrito JR, Xiao Q, Hu X, Wang Y, Gonzales E, Holtzman DM, Lee JM (2009). J Neurosci, 29(34):10706-14 Read More

Posted in: Alafi Neuroimaging, HPAN, Neurodegeneration, Neurogenetics, Neurovascular Injury & Repair, Publications, Therapeutics & Diagnostics Faculty: , ,

Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle

Posted on October 12, 2009

Kang JE, Lim MM, Bateman RJ, Lee JJ, Smyth LP, Cirrito JR, Fujiki N, Nishino S, Holtzman DM (2009). Science, 326:1005-1008 Read More

Posted in: HPAN, Neurodegeneration, Neurogenetics, Publications, Therapeutics & Diagnostics Faculty: , ,

Cerebrovascular dysfunction in amyloid precursor protein transgenic mice: contribution of soluble and insoluble amyloid-beta peptide, partial restoration via gamma-secretase inhibition

Posted on October 7, 2008

Han BH, Zhou ML, Abousaleh F, Brendza RP, Dietrich HH, Koenigsknecht-Talboo J, Cirrito JR, Milner E, Holtzman DM, Zipfel GJ (2008). J Neurosci, 28(50):13542-50. PMID:19074028 Read More

Posted in: HPAN, Neurodegeneration, Neurogenetics, Neurovascular Injury & Repair, Publications, Therapeutics & Diagnostics Faculty: , , , ,