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John Cirrito

John Cirrito‘s Faculty Page

Antidepressants show signs of countering Alzheimer’s

Posted on November 2, 2011

Serotonin reuptake inhibitors may reduce brain plaques associated with Alzheimer’s disease. Read More

Posted in: News Faculty:

Neuronal activity regulates the regional vulnerability to amyloid-beta deposition

Posted on October 12, 2011

Bero AW, Yan P, Roh JH, Cirrito JR, Stewart FR, Raichle ME, Lee JM, Holtzman DM (2011). Nat Neurosci, 14(6):750-6 Read More

Posted in: HPAN, Neurodegeneration, Neurogenetics, Neurovascular Injury & Repair, Publications, Therapeutics & Diagnostics Faculty: , , ,

In Vivo Microdialysis Reveals Age-Dependent Decrease of Brain Interstitial Fluid Tau Levels in P301S Human Tau Transgenic Mice

Posted on October 12, 2011

Yamada K, Cirrito JR, Stewart FR, Jiang H, Finn MB, Holmes BB, Binder LI, Mandelkow EM, Diamond MI, Lee VM, Holtzman DM (2011). J Neurosci, 31(37):13110-13117 Read More

Posted in: HPAN, Neurodegeneration, Neurogenetics, Publications, Therapeutics & Diagnostics Faculty: , ,

Serotonin signaling is associated with lower amyloid-beta levels and plaques in transgenic mice and humans

Posted on October 6, 2011

Cirrito JR, Disabato BM, Restivo JL, Verges DK, Goebel WD, Sathyan A, Hayreh D, D’Angelo G, Benzinger T, Yoon H, Kim J, Morris JC, Mintun MA, Sheline YI (2011). Proc Natl Acad Sci USA, 108(36):14968-73 Read More

Posted in: HPAN, Neurodegeneration, Pilot Projects, Publications, Therapeutics & Diagnostics Faculty: , ,

Opposing synaptic regulation of amyloid-beta metabolism by NMDA receptors in vivo

Posted on October 6, 2011

Verges DK, Restivo JL, Goebel WD, Holtzman DM, Cirrito JR (2011). J Neurosci, 31(31):11328-37 Read More

Posted in: HPAN, Neurodegeneration, Publications, Therapeutics & Diagnostics Faculty: ,