News & Publications for:

John Cirrito

Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle

Posted on October 12, 2009

Kang JE, Lim MM, Bateman RJ, Lee JJ, Smyth LP, Cirrito JR, Fujiki N, Nishino S, Holtzman DM (2009). Science, 326:1005-1008 Read More

Posted in: HPAN, Neurodegeneration, Neurogenetics, Publications, Therapeutics & Diagnostics Faculty: , ,

Cerebrovascular dysfunction in amyloid precursor protein transgenic mice: contribution of soluble and insoluble amyloid-beta peptide, partial restoration via gamma-secretase inhibition

Posted on October 7, 2008

Han BH, Zhou ML, Abousaleh F, Brendza RP, Dietrich HH, Koenigsknecht-Talboo J, Cirrito JR, Milner E, Holtzman DM, Zipfel GJ (2008). J Neurosci, 28(50):13542-50. PMID:19074028 Read More

Posted in: HPAN, Neurodegeneration, Neurogenetics, Neurovascular Injury & Repair, Publications, Therapeutics & Diagnostics Faculty: , , , ,

Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo

Posted on October 6, 2008

Cirrito JR, Kang JE, Lee J, Stewart FR, Verges DK, Silverio LM, Bu G, Mennerick S, Holtzman DM (2008). Neuron, 58(1):42-51 Read More

Posted in: HPAN, Neurodegeneration, Publications, Therapeutics & Diagnostics Faculty: , ,

Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo

Posted on October 6, 2005

Cirrito JR, Yamada KA, Finn MB, Sloviter RS, Bales KR, May PC, Schoepp DD, Paul SM, Mennerick S, Holtzman DM (2005). Neuron, 48(6):913-22 Read More

Posted in: HPAN, Neurodegeneration, Publications, Therapeutics & Diagnostics Faculty: , , ,