News & Publications for:

Nigel Cairns

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer’s disease

Posted on October 23, 2017

Rebecca Sims, Sven J van der Lee, Adam C Naj, Céline Bellenguez, Nandini Badarinarayan, Johanna Jakobsdottir, Brian W Kunkle, et al: 2017 Nature Genetics Volume 49, Issue 9, 1 September 2017, Pages 1373-1384 Read More

Posted in: HPAN, Neurodegeneration, Publications Faculty: ,

Diversity of Amyloid-beta Proteoforms in the Alzheimer’s Disease Brain

Posted on September 6, 2017

Norelle C. Wildburger, Thomas J. Esparza, Richard D. LeDuc, Ryan T. Fellers, Paul M. Thomas, Nigel J. Cairns, Neil L. Kelleher, Randall J. Bateman & David L. Brody: 2017 Scientific Reports 7, Article number: 9520 Read More

Posted in: Axon Injury & Repair, HPAN, Neurodegeneration, Neurogenetics & Transcriptomics, NeuroRestorative Therapy, Publications Faculty: , ,

AV-1451 PET imaging of tau pathology in preclinical Alzheimer disease: Defining a summary measure

Posted on September 6, 2017

Shruti Mishra, Brian A. Gordon, Yi Su, Jon Christensen, Karl Friedrichsen, Kelley Jackson, Russ Hornbeck, David A. Balota, Nigel J. Cairns, John C. Morris, Beau M. Ances, Tammie L. S. Benzinger: 2017 NeuroImage, Volume 161, 1 November 2017, Pages 171-178 Read More

Posted in: HPAN, Neurodegeneration, Publications Faculty: , ,

TREM2 Maintains Microglial Metabolic Fitness in Alzheimer’s Disease

Posted on August 11, 2017

Tyler K. Ulland, Wilbur M. Song, Stanley Ching-Cheng Huang, Jason D. Ulrich, Alexey Sergushichev, Wandy L. Beatty, Alexander A. Loboda, Yingyue Zhou, Nigel J. Cairns, Amal Kambal, Ekaterina Loginicheva, Susan Gilfillan, Marina Cella, Herbert W. Virgin, Emil R. Unanue, Yaming Wang, Maxim N. Artyomov, David M. Holtzman, Marco Colonna: 2017 Cell Volume 170, Issue 4, p649–663.e13 Read More

Posted in: Axon Injury & Repair, Clocks & Sleep, HPAN, Neurodegeneration, Neurogenetics & Transcriptomics, Publications Faculty: , , ,

Association of Plasma Neurofilament Light With Neurodegeneration in Patients With Alzheimer Disease

Posted on June 1, 2017

Niklas Mattsson, MD, PhD, Ulf Andreasson, PhD, Henrik Zetterberg, MD, PhD, et al: 2017 JAMA Neurol.;74(5):557-566. Read More

Posted in: Clocks & Sleep, HPAN, Neurodegeneration, Publications Faculty: , , , ,