Neurodegeneration/HPAN Group

2022/2023 Schedule

Working group for HPAN
Organizer: Jason Ulrich

  • September 14, 2022: Chihiro Sato (Bateman lab, WashU Neurology) “Amyloid toxicity and tau kinetics in neurons mimicking adult brain”
  • October 12, 2022: Andy Chen (Jackrel lab, WashU Chemistry) “A human disaggregase prevents and reverses α-Synuclein aggregation, rendering it non-toxic, non-infectious, and seeding incompetent”
  • November 9, 2022: Ben Boros (Miller lab, WashU Neurology) “Stimulating protein synthesis using antisense oligonucleotides to treat neurodegeneration”
  • December 14, 2022: Xiaoying Chen (Holtzman lab, WashU Neurology) “Neuro-immune Interactions in Alzheimer’s Disease”
  • HYBRIDJanuary 11, 2023: Muhammad Ali, Dan Western (Cruchaga lab, WashU Psychiatry)
    • Muhammad Ali: “Integrated proteomics reveals brain-based cerebrospinal fluid biomarkers in Alzheimer’s disease”
    • Dan Western: “Integration of cerebrospinal fluid pQTL analysis and disease GWAS identifies novel causal proteins for Alzheimer’s disease”
  • HYBRID February 8, 2023: Reshma Bhagat (Karch lab, WashU Psychiatry) “LncRNA-SNHG8 modifies tauopathy via stress granule formation”
  • HYBRID March 8, 2023: Steffen Storck (Kipnis lab, WashU Pathology & Immunology) “Meningeal lymphatics regulate the function of the blood-brain barrier”
  • VIRTUAL April 12, 2023: Fabia Filipello (Karch lab, WashU Psychiatry) “Defects in lysosomal function and lipid metabolism in human microglia harboring a TREM2 loss of function mutation”
  • HYBRID May 10, 2023: Nicolas Barthelemy (WashU Neurology) “Tau post-translational modifications and their clinical utility for the diagnosis of tauopathies”
2021/2022 Schedule

Working group for HPAN
Organizer: Chris Weihl

  • October 13, 2021: Dong-oh Seo (Holtzman lab, WashU Neurology) “Evidence that the gut microbiota regulates progression of neurodegeneration in a mouse model of tauopathy”
  • November 10, 2021: Brian Gordon (WashU Radiology) “Influence of APOE ε4 genotype and amyloid-β on tau in regions of high APOE mRNA expression”
  • December 8, 2021: Michio Inoue (Weihl lab, WashU Neurology) “Mutations in DNAJB4 define a novel chaperonopathy”
  • January 12, 2022: Hunter Patterson (Miller lab, WashU Neurology) “miRNAs in Moderation: Pleiotropic Effects of miR-146a in ALS”
  • February 9, 2022: Andrew Yoo (WashU Developmental Biology) “Modeling human neurodegeneration by direct neuronal reprogramming”
  • March 9, 2022: Andrea Francesca Salvador (Kipnis lab, WashU Pathology & Immunology) “The cellular and transcriptomic responses in the injured spinal cord are altered in aging”
  • April 13, 2022: Moydul Islam (Diwan lab, WashU Medicine) “Altered Phase Separation Characteristics of CRYAB, a Cardiac-enriched Chaperone, Provokes Proteotoxicity in Ischemic Cardiomyopathy”
  • May 11, 2022: Charisse Winston-Gray (University of California, San Diego) “Biomarker and Pathogenic Potential of Blood-Based Exosomes in Alzheimer’s Disease”
2020/2021 Schedule

Working group for HPAN
Organizer: Chris Weihl

  • October 14, 2020: William Buchser (WashU Genetics) “Functional Imaging for Variant Elucidation – Deep Mutational Scanning with Relevant Phenotypes”
  • November 11, 2020: Samira Parhizkar (Holtzman lab, WashU Neurology) “Deciphering the role of sleep on neuroinflammation and neurodegeneration”
  • December 9, 2020: Matthew Figley (DiAntonio lab, WashU Developmental Biology) “A mechanism of metabolic sensing by SARM1 to trigger axon degeneration”
  • January 13, 2021: Bruno Benitez (WashU Psychiatry) “The Autophagy Lysosomal Pathway and Neurodegeneration: a functional perspective”
  • February 10, 2021: Macy Sprunger (Jackrel lab, WashU Chemistry) “Elucidating the molecular drivers of MATR3 proteinopathy implicated in ALS and FTD”
  • March 10, 2021: Jiang Zhu (Weihl lab, WashU Neurology) “The role of the endolysosomal pathway on proteopathic seeding activities”
  • April 14, 2021: Patrick Sheehan (Musiek lab, WashU Neurology) “Astrocytic BMAL1 regulates protein aggregation in mouse models of alpha-synuclein and tau pathology”
  • May 12, 2021: Moydul Islam (Diwan lab, WashU Medicine) “Elucidating the role of protein aggregation in Ischemic Cardiomyopathy”
  • June 9, 2021: Naresha Saligrama (WashU Neurology) “Exploration of phenotype, function, and specificity of T cells in Neurological Diseases”
2019/2020 Schedule

Working group for HPAN
Organizer: Chris Weihl

  • September 11, 2019: Beau Ances (WashU Neurology) “Comparisons between Autosomal Dominant AD and Late Onset AD”
  • October 9, 2019: Dmitriy Yablonskiy (WashU Radiology) “In vivo detection of neurodegeneration with quantitative genetically-enabled MRI: principles and applications to Alzheimer disease and Multiple Sclerosis”
  • November 13, 2019: Hemanth Ramesh Nelvagal (Cooper lab, WashU Pediatrics) “Early disease phenotypes in a mouse model of Infantile Batten (CLN1) disease”
  • December 11, 2019: Anil Cashikar (WashU Psychiatry) “Modulation of neuroinflammation by an oxysterol”
  • January 8, 2020: Monica Xiong (Holtzman lab, WashU Neurology) “ApoE immunotherapy reduces vascular amyloid pathology and rescues cerebrovascular dysfunction”
  • February 12, 2020: John Cirrito (WashU Neurology) “Interplay of orexin and dynorphin on regulating Aβ levels”
  • March 11, 2020: Zachary Grese (Ayala lab, Saint Louis University) “RNA-based tools to prevent TDP-43 aggregation”
  • CANCELLED – April 8, 2020: Weihl lab (WashU Neurology)
  • CANCELLED – May 13, 2020: Karch lab (WashU Psychiatry)
  • CANCELLED – June 10, 2020: Miller lab (WashU Neurology)