List of publications for the week of June 1, 2021
Wireless multilateral devices for optogenetic studies of individual and social behaviors
(2021) Nature Neuroscience, .
Yang, Y.a , Wu, M.b , Vázquez-Guardado, A.c , Wegener, A.J.d e , Grajales-Reyes, J.G.f , Deng, Y.a g h i , Wang, T.j , Avila, R.a c h i , Moreno, J.A.d e k , Minkowicz, S.b , Dumrongprechachan, V.b l , Lee, J.m , Zhang, S.a c h i n , Legaria, A.A.f , Ma, Y.o , Mehta, S.p , Franklin, D.c i , Hartman, L.q , Bai, W.c i , Han, M.c , Zhao, H.c , Lu, W.c , Yu, Y.l , Sheng, X.r , Banks, A.c m s , Yu, X.t , Donaldson, Z.R.u , Gereau, R.W., IVf , Good, C.H.c d e , Xie, Z.v , Huang, Y.a c h i , Kozorovitskiy, Y.b l , Rogers, J.A.a i m q s w x y z
a Department of Mechanical Engineering, Northwestern University, Evanston, IL, United States
b Department of Neurobiology, Northwestern University, Evanston, IL, United States
c Center for Bio-Integrated Electronics, Northwestern University, Evanston, IL, United States
d US Army Research Laboratory, Aberdeen Proving Ground, MD, United States
e US Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD, United States
f Washington University Pain Center and Department of Anesthesiology, Washington University, St. Louis, MO, United States
g State Key Laboratory of Mechanical System and Vibration, Shanghai Jiao Tong University, Shanghai, China
h Department of Civil and Environmental Engineering, Northwestern University, Evanston, IL, United States
i Department of Materials Science and Engineering, Northwestern University, Evanston, IL, United States
j Department of Physics, Tsinghua University, Beijing, China
k SURVICE Engineering, Belcamp, MD, United States
l Chemistry of Life Processes Institutes, Northwestern University, Evanston, IL, United States
m Neurolux Inc, Evanston, IL, United States
n School of Civil Engineering, Southwest JiaoTong University, Chengdu, China
o School of Chemical Engineering and Technology, Tianjin University, Tianjin, China
p CSIR-Central Scientific Instruments Organization, Ministry of Science & Technology, Sector 30-C, Chandigarh, India
q Department of Biomedical Engineering, Northwestern University, Evanston, IL, United States
r Department of Electronic Engineering, Tsinghua University, Beijing, China
s Simpson Querrey Institute & Feinberg Medical School, Northwestern University, Evanston, IL, United States
t Department of Biomedical Engineering, City University of Hong Kong, Kowloong Tong, Hong Kong
u Psychology and Neuroscience, Molecular Cellular and Developmental Biology, University of Colorado Boulder, Boulder, CO, United States
v State Key Laboratory of Structural Analysis for Industrial Equipment, Department of Engineering Mechanics, Dalian University of Technology, Dalian, China
w Department of Chemistry, Northwestern University, Evanston, IL, United States
x Department of Neurological Surgery, Northwestern University, Evanston, IL, United States
y Department of Electrical and Computer Engineering, Northwestern University, Evanston, IL, United States
z Department of Computer Science, Northwestern University, Evanston, IL, United States
Abstract
Advanced technologies for controlled delivery of light to targeted locations in biological tissues are essential to neuroscience research that applies optogenetics in animal models. Fully implantable, miniaturized devices with wireless control and power-harvesting strategies offer an appealing set of attributes in this context, particularly for studies that are incompatible with conventional fiber-optic approaches or battery-powered head stages. Limited programmable control and narrow options in illumination profiles constrain the use of existing devices. The results reported here overcome these drawbacks via two platforms, both with real-time user programmability over multiple independent light sources, in head-mounted and back-mounted designs. Engineering studies of the optoelectronic and thermal properties of these systems define their capabilities and key design considerations. Neuroscience applications demonstrate that induction of interbrain neuronal synchrony in the medial prefrontal cortex shapes social interaction within groups of mice, highlighting the power of real-time subject-specific programmability of the wireless optogenetic platforms introduced here. © 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.
Funding details
National Institute of Neurological Disorders and StrokeNINDSR01NS106953, T32GM07200
Materials Research Science and Engineering Center, Harvard UniversityMRSECDMR-1720139
Rita Allen FoundationRAFT32 AG20506, DGE1842165, DP2OD026143
Northwestern UniversityNU
National Institutes of HealthNIHR01NS107539, R01MH117111
5F31NS10347202
Dana Foundation
National Science FoundationNSFECCS1542205
Whitehall Foundation
National Cancer InstituteNCICCSG P30 CA060553, P30 CA060553
National Science FoundationNSFCMMI1635443
National Natural Science Foundation of ChinaNSFC12072057
Fundamental Research Funds for the Central UniversitiesDUT20RC(3)032
Document Type: Article
Publication Stage: Article in Press
Source: Scopus