The Hope Center Lecture is presented at the Annual Hope Center Retreat

2024 Hope Center Lecture

Joseph Lewcock, PhD

Chief Scientific Officer and Head of Discovery
Denali Therapeutics

Targeting brain delivery of biotherapeutics for neurodegenerative disease

Abstract: In this presentation, I will discuss our efforts at Denali to develop novel therapeutics for the treatment of neurodegenerative diseases ranging from rare monogenic disorders to Alzheimer’s Disease. Our approach leverages our platform for delivery of therapeutics to the CNS combined with an improved mechanistic understanding of disease. The presentation will include both preclinical data and clinical data from our programs. 

Hope Center Lectures

2023: Michael Ward, MD, PhD (National Institute of Neurological Disorders & Stroke/National Institutes of Health)

2022: Louise Rodino-Klapac, PhD (Sarepta Therapeutics, Inc.), Martin Kampmann, PhD (University of California, San Francisco)

2021: Merit Cudkowicz (Harvard Medical School/Massachusetts General Hospital)

2019: Guoping Feng (Massachusetts Institute of Technology), Sally Temple (Neural Stem Cell Institute)

2018: Leonard Petrucelli, PhD (Mayo Clinic Florida)

2017: Laura Ranum (University of Florida)

2016: Beverly Davidson (University of Pennsylvania)

2015: Daria Mochly-Rosen (Stanford University)

2014: Al Sandrock (Biogen Idec)

2013: Ryan Watts (Genentech)

2012: David Julius (University of California, San Francisco)

2011: Jeffery Kelly (The Scripps Research Institute)

2010: Harry Orr (University of Minnesota)

2009: Marc Tessier-Lavigne (Genentech)

2008: Ben Barres (Stanford University)

2007: Steve Wagner (TorreyPines Therapeutics)