Recognizing trainees’ exceptional research and presentations at the Annual Hope Center Retreat

Overview

The Hope Center Awards are designed to acknowledge scientific accomplishments and presentation by trainees who give a talk or present a poster at the Annual Hope Center Retreat. All Washington University pre-doctoral students and postdoctoral trainees who are selected to present their work at the Hope Center Retreat are eligible to participate in the awards competition if the work was conducted at Washington University. Winners receive a $1000 award.

Congratulations to the 2023 Award Winners

Short talks

Megan Bosch, PhD

Postdoctoral research scholar
in the lab of David Holtzman

“Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia
in a dose- and sex-specific manner”

Posters

Collin Nadarajah

Graduate student
in the lab of Erik Musiek

“An astrocyte BMAL1-BAG3 axis regulates glial activation and protein aggregation
in mouse models of alpha-synuclein
and tau pathology”

Join us for a Special Hope Center/Neurology Seminar on June 5th at 12p for presentations by Megan and Collin. The seminar will be held in Holden Auditorium and via Zoom.

Congratulations to all of the finalists!

Talk Finalists

  • Sheng (Andy) Chen (Jackrel lab, WashU Chemistry) – “HtrA1 prevents and reverses α-synuclein aggregation, rendering it non-toxic and seeding incompetent”
  • Daniel Western (Cruchaga lab, WashU Psychiatry) – “Integration of cerebrospinal fluid pQTL and GWAS prioritizes novel candidate genes involved in Alzheimer’s disease”
  • Reshma Bhagat (Karch lab, WashU Psychiatry) – “Long non-coding RNA SNHG8 drives stress granule formation in MAPT mutation carriers”
  • Chengcheng Li (Weihl lab, WashU Neurology) – “Comprehensive functional characterization of SGCB variants causing Limb-Girdle Muscular Dystrophy”
  • Rui (Rikki) Feng (Cavalli lab, WashU Neuroscience) – “Antagonizing Endothelin B receptor in satellite glial cells improves nerve regeneration and aging-dependent neuronal regenerative decline”
  • Bridget Phillips (Cruchaga lab, WashU Psychiatry) – “Proteome Wide Association Studies of LRRK2 variants identify novel causal and druggable proteins for Parkinson’s disease”
  • Danira Toral Rios (Cashikar/Paul lab, WashU Psychiatry) – “25-hydroxycholesterol mediates neuroinflammation and neurodegeneration in a tauopathy mouse model”

Poster Finalists

  • Diana Grigore (Buchser lab, WashU Genetics) – “Neuronal Phenotyping of Mitochondria via Raft-based Pooled Imaging”
  • Shreedarshanee Shamulailatpam (Gallardo lab, WashU Neurology) – “Astrocytic α2-Na + /K + ATPase inhibition suppresses astrocyte reactivity and reduces neurodegeneration in a tauopathy mouse model”
  • Michael Strickland (Holtzman lab, WashU Neurology) – “Investigation of ApoE Structure using CryoEM Reveals New Molecular Mechanism for Receptor Binding”
  • Chanung Wang (Holtzman lab, WashU Neurology) – “APOE-ε4 synergizes with sleep disruption to accelerate Aβ deposition and Aβ-associated tau seeding and spreading”
Thanks to faculty members who served as judges
for the short talks and the posters!
Previous Hope Center Award winners

2022

Dana Shaw, PhD, postdoc in the lab of Mayssa Mokalled
“An intricate immune balance necessary for natural spinal cord regeneration”

Alexandra Litvinchuk, PhD, postdoc in the lab of David Holtzman
“The relationship between ApoE and lipid dysregulation in glia of the PS19 mouse model of tauopathy”

2021

Maud Gratuze, PhD, postdoc in the lab of David Holtzman
“Activated microglia mitigate Aβ-associated tau seeding and spreading”

2019

Andrew Findlay, MD, clinical fellow in the lab of Chris Weihl
“Lithium chloride corrects weakness and myopathology in a preclinical model of LGMD1D”

Zachary Rosenthal, graduate student in the lab of Jin-Moo Lee
“Local perturbations in cortical excitability propagate differentially through large-scale functional networks”

2018

Scott Karney-Grobe, graduate student in the lab of Aaron DiAntonio
“HSP90 is a chaperone for DLK and is required for axon injury signaling”

Alex Cammack, graduate student in the lab of Tim Miller
“C9orf72 G4C2 repeat expansions in ALS patients are dynamic and result in large dipeptide repeat proteins”

2017

Yedda Li, graduate student in the lab of Mark Sands
“Combination therapy increase lifespan and improves clinicobehavioral performance in the murine model of globoid cell leukodystrophy”

Kathleen Schoch, PhD, postdoc in the lab of Tim Miller
“Antisense oligonucleotide-mediated reduction of TREM2 mRNA in mouse models of Alzheimer’s disease and tauopathy”

2016

Lauren Walker, graduate student in the lab of Aaron DiAntonio
“MAPK signaling functions upstream of SARM1 to promote axonal degeneration”

Cheryl Leyns, graduate student in the lab of David Holtzman
“Direct delivery of full-length, therapeutic anti-tau antibodies to the brain by gene transfer”

2015

Sarah Petersen, PhD, postdoc in the lab of Kelly Monk
“GPR126 has distinct, domain-dependent functions in Schwann cell development mediated by interaction with laminin-211”

Matheus Victor, graduate student in the lab of Andrew Yoo
“Modeling Huntington’s Disease with striatal medium spiny neurons directly converted from patient fibroblasts”

2014

Shannon Macauley-Rambach, PhD, postdoc in the lab of David Holtzman
“Investigating the mechanistic link between diabetes and Alzheimer’s disease: the effects of the hyperglycemia on neuronal activity and Amyloid beta levels within the brain’s interstitial fluid”

Matthew MacEwan, graduate student in the labs of Dan Moran and Wilson Ray
“Neuroregenerative electrodes enable functional electrical stimulation of peripheral motor axons and distal musculature”

Sarah Kaufman and David Sanders, graduate students in the lab of Marc Diamond
“Distinct tau prion strains propagate in cells and mice and define different tauopathies”

2013

Sarah DeVos, graduate student in the lab of Timothy Miller
“Tau Knockdown in the Adult Mouse Significantly Reduces Severity of Excitotoxic Seizures”

Najla Kfoury, PhD , postdoc in the lab of Marc Diamond
“Soluble tau aggregate seeds are present in brain, CSF and plasma of AD patients, and predict cognitive decline”

2012

Josiah Gerdts, graduate student in the lab of Jeff Milbrandt
“High-throughput screening identifies novel genes required for Wallerian Degeneration in primary mouse neurons”

Brandon Holmes, grad student in the lab of Marc Diamond
“Heparan Sulfate Proteoglycans Constitute a Major Pathway for Pathogenic Tau Seed Internalization”

2011

Adam Bero, graduate student in the lab of Dave Holtzman
“Neuronal activity regulates the regional vulnerability to amyloid-β deposition”

Shannon Macauley-Rambach, graduate student in the lab of Mark Sands
“The role of astrocyte activation in both the pathogenesis and treatment of infantile neuronal ceroid lipofuscinosis (INCL)”

2010

Rebecca Craig-Schapiro, graduate student in the lab of Dave Holtzman
“YKL-40: A Novel Diagnostic and Prognostic Fluid Biomarker for Early Alzheimer’s Disease”

Jungsu Kim, PhD, postdoc in the lab of Dave Holtzman
“Overexpression of Low-Density Lipoprotein Receptor in the Brain Markedly Inhibits Amyloid Deposition and Increases Extracellular Aβ Clearance”

2009

Andrew Kraft, undergraduate in the lab of Jin-Moo Lee
“Activated astrocytes suppress amyloid plaque pathogenesis in APP/PS1 mice”

Shiyam Rao, MD, fellow in the lab of Josh Rubin
“Disruption of GBM-Endothelial Cell Interactions Through Antagonism of CXCR4 Signaling Inhibits Tumor Cell Growth”

2008

Craig Press, graduate student in the lab of Jeff Milbrandt
“Nmnat delays axonal degeneration caused by mitochondrial and oxidative stress”

Qiang Liu, PhD, postdoc in the lab of Guojun Bu
“Amyloid Precursor Protein Regulates Brain Apolipoprotein E and Cholesterol Metabolism through Lipoprotein Receptor LRP1″

2007

Biyu He, undergraduate in the lab of Maurizio Corbetta
“Breakdown of intrinsic brain synchrony in spatial neglect: a novel mechanism to explain brain-behavior relationships after stroke”

Fernanda Laezza, PhD, postdoc in the labs of David Ornitz and Jeanne Nerbonne
“A single mutation in FGF14 interferes with function of voltage-gated sodium channels in mammalian neurons”

2006

Elizabeth Tank, graduate student in the lab of Heather True-Krob
“PrP Repeat Expansions Confers Enhanced Structural Variability”

Elizabeth Tank, graduate student in the lab of Heather True-Krob
“PrP Repeat Expansions Confers Enhanced Structural Variability”

Conrad (Chris) Weihl, MD, PhD, postdoc in the labs of Phyllis Hanson and Alan Pestronk
“Using both cellular and animal models of hereditary inclusion body myositis (IBM) to explore the underlying pathogenesis of Alzheimer’s Disease”

2005

Michelle Schlief, graduate student in the lab of Jonathan Gitlin
“Novel insights into the mechanism of neurodegeneration in Menkes disease: copper-dependent excitotoxic neuroprotection”

David Brody, MD, PhD, postdoc in the lab of David Holtzman
“Anti-Aβ antibody attenuates cognitive impairment in a model of experimental traumatic brain injury”