Click a year below to learn more about each project, including grants, published manuscripts and intellectual property that followed from pilot projects.
2022 Pilot Projects
2022 Awards
- Effect of Air Pollution on Abeta and Tau Metabolism in Mice
- Alzheimer’s disease pathology in patients with multiple sclerosis
- High-throughput Pathogenicity Prediction of FKTN Gene Variants causing Congenital Muscular Dystrophy with Brain and Eye anomalies
- Harnessing pro-regenerative immune responses to promote spinal cord repair
2021 Pilot Projects
2021 Awards
- Patient-Specific Neuroimaging Markers of Recovery After Traumatic Brain Injury
- A model of human neuroprotection
- Brain injury creates a supportive microenvironment for tumorigenesis
- Mapping ketamine-orchestrated translatome to rapid-acting anti-anhedonic effects at the synaptic level with cell-type specific resolution
- VEGFA as a potential therapeutic target to enhance motor recovery following acute and chronic nerve injury
2020 Pilot Projects
2020 Awards
- Role of satellite glia cells in chemotherapy-induced neuropathy
- Microglial Phagocytosis as a Determinant of Neuro-inflammation in AD pathogenesis
- Defining the molecular basis for inhibiting LRP1-mediated cellular propagation of pathogenic tau
- A synthetic gene therapy approach for Angelman syndrome
- Targeting DNMT3A as a therapeutic strategy for Huntington’s disease
2019 Pilot Projects
2019 Awards
- Determining the pathogenic role of FGFR3 autoantibodies in idiopathic small fiber neuropathy
- Reversibility of amyloid-induced mitochondrial dysfunction in Alzheimer’s disease
- SARM1 inhibition as a novel therapeutic strategy for Cln1 disease
- Internet of things (IoT) monitoring of rodent home-cages to understand circadian plasticity
- DNA methylation in Alzheimer’s disease
2018 Pilot Projects
2018 Awards
- Reprogramming rod photoreceptors to treat retinal degeneration
- Developing Biomarkers for chemotherapy-induced peripheral neuropathy
- Defining the mechanisms by which MS4A4A regulates TREM2 in Alzheimer disease
- Utilizing Human Embryonic Stem Cell-Based Disease Models to Identify the Malignant Epigenetic State in Glioblastoma
- Identification of Repurposed Prescription Medications as Neuroprotective Therapy for Amyotrophic Lateral Sclerosis
2017 Pilot Projects
2017 Awards
- Unraveling the Mechanisms of Neuroma Prevention with the Use of Acellularized Nerve Allografts
- Regulation of stop codon readthrough of Aqp4 and role in Aβ clearance
- Eliciting Sensory Percepts by Macrosieve Stimulation of the Rat Sciatic Nerve
- Role of Lysosomal Dysfunction in Aggregation and Spreading of Alpha-synuclein in vitro and in vivo
2016 Pilot Projects
2016 Awards
- Dissecting Downstream SCN Neural Circuits in Sleep and Arousal
- Transmissible protein aggregation in myodegenerative diseases
- Development of a bioengineered construct library to repair long nerve defects
2015 Pilot Projects
2015 Awards
- Fixing the Broken Clock: Optogenetic methods to restore circadian rhythms in a mouse model of Alzheimer’s Disease
- Mechanisms of neonatal seizures in a mouse model of term-equivalent cerebral hypoxia-ischemia
- MicroRNA regulation of dendritic cell function in an animal model of multiple sclerosis
- The role of DNA methylation in Huntington’s disease
2014 Pilot Projects
2014 Awards
- Neuronal subtype-specific vulnerability in tauopathies using reprogramming methods in human somatic and stem cells
- Identification and functional characterization of rare variants in DNAJC5/CSP gene associated with Alzheimer Disease
- Characterization of neural bridge circuits for spinal cord repair
- MR Elastography and CSF Biomarkers in Post-Hemorrhagic Hydrocephalus
- Role of nicotinamide adenine dinucleotide (NAD+) metabolism in the pathogenesis of retinal neurodegeneration
2013 Pilot Projects
2013 Awards
- Promoting axonal regeneration in models of ALS via activation of the preconditioning response in iPSC-derived human neurons
- TREM2 signaling as a biomarker and therapeutic target in ALS
- Using biosensors to identify therapy-driven brain reorganization in children
2012 Pilot Projects
2012 Awards
- Axonal Injury in Intracerebral Hemorrhage
- Modulation of proteostasis for treatment of Niemann-Pick C disease
- Immunomodulatory role of plasmacytoid dendritic cells in multiple sclerosis
2011 Pilot Projects
2011 Awards
- DNAJB6 in protein aggregation: Integration of clinical material, mouse models and yeast genetics
- Quantitation of Amyloid-β peptides in CSF of Alzheimer’s disease participants by immunoprecipitation/mass spectrometry (IP/MS) and solid phase extraction/mass spectrometry (SPE/MS)
- Isolating Cell-Type Specific miRNAs from Mice
- Noninvasive white matter histology of living EAE mice
2010 Pilot Projects
2010 Awards
- Citalopram Decreases Aβ Plaque Accumulation in APP Mice and CSF Aβ in Humans
- Identification and functional characterization of the genetic variant causing Kufs’ disease with early dementia in a family with an autosomal dominant inheritance
- Cis-regulatory mapping of dominant human retinal neurodegenerative disorders
- Mechanism of Huntington Aggregation Regulated by Profilin
2009 Pilot Projects
2009 Awards
- PET tracers for cerebrovascular-specific amyloid imaging
- Generating Amyloid Seeds in Lysosomes
- Understanding How the Liver Successfully Handles Misfolded SOD1
2008 Pilot Projects
2008 Awards
- Inhibition of the DLK/JNK Pathway as a Therapeutic Target for Axonopathy
- Functional RNAi screen to identify pathways essential for protein aggregate clearance and degradation
2007 Pilot Projects
2007 Awards
- Misfolded protein accumulation and neurodegeneration due to phospholipase gene mutations
- Function of FGF14 in progressive spinocerebellar ataxia
- Microdevice development for the study of axon degeneration and injury
- Development of a Clinically Relevant Model of Infant Traumatic Brain Injury
2006 Pilot Projects
2006 Awards
- Unraveling the amyloid fibril with polyphenols
- In vivo labeled proteomics in human CSF
- Use of hybrid mammalian-yeast prions to identify factors that inhibit protein aggregation
2005 Pilot Projects
2005 Awards
- Genetics of Amyotrophic Lateral Sclerosis
- Inhibitors of Sodium Channels as Axonal Protectants in Experimental Autoimmune Encephalomyelitis
- Stimulating Axonal Protection in ALS via Activation of Nuclear NAD Biosynthesis