Organizer: Anil Cashikar

Lipid metabolism in the brain has been identified as highly impactful for neuroinflammation. It is well known that apolipoprotein E (ApoE), the main lipid carrier protein in the brain, is the biggest risk factor for Alzheimer’s disease. Dysfunction in lipid efflux and lipid storage pathways appear to be strongly associated with inflammatory activation of glia. Targeting specific aspects of the brain lipid metabolism may offer therapeutic opportunities. The new Lipid Metabolism Research Group gathers those who have made pioneering contributions in understanding the connection between lipid metabolism, immune activation and neurological/psychiatric disorders, and others who would like to know more about these contributions, better understand the role of lipid metabolism in health and disease, exchange ideas, methodology and reagents and explore opportunities for identification of existing resources and development of new resources.

2024 Summer/Fall Schedule

2nd Friday of the month
2:30p – 3:30p
Zoom conference

For virtual meeting information email the Hope Center or click the Zoom links button below.

  • June 14: Andrew Roth (Philips lab, WashU Medicine) “Beyond Metabolism: Understanding the Role of Cholesterol Oxidation in Tuberculosis”
  • July 12: Yuqing Zhu (Skeath lab, WashU Genetics) “Loss of dihydroceramide desaturase drives neurodegeneration by disrupting endoplasmic reticulum and lipid droplet homeostasis in glial cells”
  • August 9: Johnathan Romero (Cashikar lab, WashU Psychiatry) “25-hydroxycholesterol promotes brain cytokine production and leukocyte infiltration in a mouse model of lipopolysaccharide-induced neuroinflammation
  • CANCELLEDSeptember 13
  • October 11: Ciyang Wang (Cruchaga lab, WashU Psychiatry)
  • November 8: Travis Tabor (Holtzman lab, WashU Neurology)
  • December 13: Yun Chen (Holtzman lab, WashU Neurology)

All meetings are listed on the ONR Calendar of the Office of Neuroscience Research.

Lipid Metabolism Group: Affiliated faculty members

Anil Cashikar (WashU Psychiatry)
Jonathan Cooper (WashU Pediatrics)
Carlos Cruchaga (WashU Psychiatry)
Albert (Gus) Davis (WashU Neurology)
Abhinav Diwan (WashU Medicine)
Alex Evers (WashU Anesthesiology)
David Ford (Saint Louis University)
Song Hu (WashU Biomedical Engineering)
Laura Ibanez (WashU Psychiatry)
Joseph Ippolito (WashU Radiology)
Celeste Karch (WashU Psychiatry)
David Kast (WashU Cell Biology & Physiology)
Erik Musiek (WashU Neurology)
Grace Niziolek (WashU Surgery)
Jennifer Philips (WashU Medicine)
Gwendalyn Randolph (WashU Pathology & Immunology)
Daniela Salvemini (Saint Louis University)
Clay Semenkovich (WashU Medicine)
Ikbal Sencan-Egilmez (WashU Radiology)
Ananth Vellimana (WashU Neurosurgery)