Lysosome Processing & Transport

Organizer: Celeste Karch

The Lysosome Processing & Transport Group is a group of investigators whose research goals range from basic lysosomal system biology to therapy in model organisms and humans. The focus of this group is to introduce key research developments and current innovative studies in the lysosome field. Members of this group share an interest in the autophagy/lysosomal pathway (ALP) and its relationship to neurodegenerative disorders, development of novel therapeutic strategies of Lysosome storage diseases and the use of cell and animal models as tools to determine the role of the ALP in the pathogenesis of neurological and cardiovascular diseases. 

Group meetings are open to the Washington University community, and those outside also are welcome to present their work and exchange new data and cutting-edge ideas.

2024 Spring Schedule

3rd Thursday of the month
3:00p – 4:00p
Zoom conference

Check back for the list of presenters and talk titles!

Zoom link (WUSTL Key required)
  • January 18: Sandra Encalada (The Scripps Research Institute) “Activation of Neuronal Degradative Pathways to Ameliorate Prion Disease”
  • February 15: Keigo Takahashi (Cooper lab, WashU Pediatrics) “Defining the contribution of GABAergic interneuron deficits to epileptogenesis in neurodegenerative lysosomal storage disorders”
  • March 21: Yan Xiong (Sardiello lab, WashU Pediatrics) “TFEB degradation is regulated by an IKK/β-TrCP2 phosphorylation-ubiquitination cascade”
  • April 18: Hui Ye (Baylor College of Medicine) “An Evolutionarily Conserved Role of Retromer in Orchestrating Traffic between Synapses and Lysosomes”
  • May 16: Michio Inoue (Weihl lab, WashU Neurology)

For previous years’ talks, check out the archives link below.

All meetings are listed on the ONR Calendar of the Office of Neuroscience Research.

Meeting archives
Lysosome Processing & Transport Group: Affiliated faculty members

Jonathan Cooper (WashU Pediatrics)
Carlos Cruchaga (WashU Psychiatry)
Patricia Dickson (WashU Pediatrics)
Abhinav Diwan (WashU Medicine)
Claudia Han (WashU Pathology & Immunology)
Timothy Holy (WashU Neuroscience)
Celeste Karch (WashU Psychiatry)
Jonathan Kipnis (WashU Pathology & Immunology)
Stuart Kornfeld (WashU Medicine)
Jin-Moo Lee (WashU Neurology)
Adriana Montaño (Saint Louis University)
Andrew Nguyen (Saint Louis University)
Maria Remedi (WashU Medicine)
Rajan Sah (WashU Medicine)
Mark Sands (WashU Medicine)
Gary Silverman (WashU Pediatrics)
Amber Stratman (WashU Cell Biology & Physiology)