Organizer: Celeste Karch, Farzaneh Mirfakhar
The Lysosome Processing & Transport Group is a group of investigators whose research goals range from basic lysosomal system biology to therapy in model organisms and humans. The focus of this group is to introduce key research developments and current innovative studies in the lysosome field. Members of this group share an interest in the autophagy/lysosomal pathway (ALP) and its relationship to neurodegenerative disorders, development of novel therapeutic strategies of Lysosome storage diseases and the use of cell and animal models as tools to determine the role of the ALP in the pathogenesis of neurological and cardiovascular diseases.
Group meetings are open to the Washington University community, and those outside also are welcome to present their work and exchange new data and cutting-edge ideas.
2025 Schedule
3rd Thursday of the month
3:00p – 4:00p
Zoom conference
For inquiries contact the Hope Center.
- January 16: Clarissa Waites (Columbia University) “Mechanisms of ESCRT transport and recruitment to synapses”
- February 20: Kenji Lim (Diwan lab, WashU Medicine) “Lysosomal antigen processing in immune checkpoint inhibitor-associated myocarditis”
- March 20: Swetha Gowrishankar (University of Illinois, Chicago) “Neuronal Lysosome Transport and Function: Links to Neurodegenerative Diseases”
- April 17: Grant Austin (Dickson lab, WashU Pediatrics) “Enzyme Replacement for LSDs: Using Basic Science to Solve Clinical Problems”
- May 15: Simon Sander (University of California, San Francisco) “Investigating Chaperone-Meditated Autophagy (CMA) by cryo-EM”
For previous years’ presentations, check out the archives link below.
All meetings are listed on the ONR Calendar of the Office of Neuroscience Research.
- September 19: Arun Renganathan (Karch lab, WashU Psychiatry) “Discovery of a novel long non-coding RNA that regulates autophagy and promotes protein aggregation”
- October 17: Mark Sands (WashU Medicine) “Haploinsufficiency of lysosomal enzymes and Alzheimer’s disease”
- November 21: Joanna Jankowsky (Baylor College of Medicine) “TMEM106B: A small protein with a big impact on dementia”
Jonathan Cooper (WashU Pediatrics)
Carlos Cruchaga (WashU Psychiatry)
Patricia Dickson (WashU Pediatrics)
Abhinav Diwan (WashU Medicine)
Claudia Han (WashU Pathology & Immunology)
Timothy Holy (WashU Neuroscience)
Celeste Karch (WashU Psychiatry)
Jonathan Kipnis (WashU Pathology & Immunology)
Stuart Kornfeld (WashU Medicine)
Jin-Moo Lee (WashU Neurology)
Adriana Montaño (Saint Louis University)
Andrew Nguyen (Saint Louis University)
Maria Remedi (WashU Medicine)
Rajan Sah (WashU Medicine)
Mark Sands (WashU Medicine)
Gary Silverman (WashU Pediatrics)
Amber Stratman (WashU Cell Biology & Physiology)