Mai Dang, MD, PhD

Defining the functional heterogeneity of microglia and macrophages in pediatric brain tumors

Using a wide variety of tools including immunocompetent brain tumor animal models, single-cell analysis, and advanced imaging, we are interrogating the multiplicity of the anti- and pro-tumor functions of these myeloid cells. The aims of our investigations are 1) to leverage the myeloid cells’ direct and indirect contributions to tumor cell killing during treatments such as radiation and molecular-targeted inhibitors to improve treatment efficacy; and 2) to understand how intratumoral microglia interact with the surrounding normal brain during tumor development, treatment, and recovery after treatment

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