A guiding principle of the Hope Center is that cell and molecular biological processes that underlie neurodegeneration are similar across disorders, such that research findings can be leveraged to provide insight beyond just one disease. Through the organization of research groups, the Hope Center aims to promote the sharing of unpublished data, foster collaboration, and speed the process of translation. To learn more about each group including its goals, the schedule of meeting presenters, and the list of participating faculty, click the buttons below.
Axon Injury & Repair
Axon Injury & Repair Group investigators study many aspects of axon biology, including the cell biology and signaling mechanisms that underlie axonal and synaptic responses to trauma or disease, mechanisms that enable repair, and translational approaches to assessing axonal integrity in animals and humans.
Clocks & Sleep Club
Clocks and Sleep Club is a journal club at Washington University that discusses recent advances in the study of biological timing and sleep.
Lysosome Processing & Transport
Investigators in the Lysosome Processing & Transport Group are interested in diverse aspects of lysosome biology as well as development of therapeutic strategies for lysosomal storage diseases.
Neurogenetics & Transcriptomics
The Neurogenetics & Transcriptomics Group is a diverse group of investigators whose independent research programs range from human genetics to genetic model organisms. They share an interest in the genetic pathways underlying neurological disorders, techniques to identify those genetic pathways, and the use of genetics and genomics as tools to develop therapeutics.
The NeuroRestorative Therapy Group investigates ways to restore neurological function in patients suffering from diseases that impact the human nervous system, through the development of novel multidisciplinary therapeutic strategies.
Neurovascular Injury & Repair
The Neurovascular Injury & Repair group provides a forum to discuss novel concepts and mechanisms in disorders of the neurovascular unit. Emphasis is placed on the causes of neurovascular injury and repair/response mechanisms in diseases of the central or peripheral nervous system.
Protein Aggregation & Neurodegeneration
The Protein Aggregation & Neurodegeneration Group represents the most formalized of the Hope Center Research groups, HPAN. HPAN’s goal is to develop better ways to diagnose and treat neurodegenerative diseases through an understanding of the underlying molecular mechanisms that lead to protein aggregation and disease.