Research forums to share unpublished findings and foster collaborative research Read More

A guiding principle of the Hope Center is that cell and molecular biological processes that underlie neurodegeneration are similar across disorders, such that research findings can be leveraged to provide insight beyond just one disease.  Through the organization of research groups, the Hope Center aims to promote the sharing of unpublished data, foster collaboration, and speed the process of translation.  To learn more about each group including its goals, the schedule of meeting presenters, and the list of participating faculty, click the buttons below.

Axon Injury & Repair

Axon Injury & Repair Group investigators study many aspects of axon biology, including the cell biology and signaling mechanisms that underlie axonal and synaptic responses to trauma or disease, mechanisms that enable repair, and translational approaches to assessing axonal integrity in animals and humans.


Clocks & Sleep Club

Clocks and Sleep Club is a journal club at Washington University that discusses recent advances in the study of biological timing and sleep.

Clocks & Sleep

NEW – Lipid Metabolism

The new Lipid Metabolism Research Group gathers those who have made pioneering contributions in understanding the connection between lipid metabolism, immune activation and neurological/psychiatric disorders, and others who would like to know more about these contributions, better understand the role of lipid metabolism in health and disease, exchange ideas, methodology and reagents and explore opportunities for identification of existing resources and development of new resources.

Lipid Metabolism

Lysosome Processing & Transport

Investigators in the Lysosome Processing & Transport Group are interested in diverse aspects of lysosome biology as well as development of therapeutic strategies for lysosomal storage diseases.


Neurogenetics & Transcriptomics

The Neurogenetics & Transcriptomics Group is a diverse group of investigators whose independent research programs range from human genetics to genetic model organisms.  They share an interest in the genetic pathways underlying neurological disorders, techniques to identify those genetic pathways, and the use of genetics and genomics as tools to develop therapeutics.

Neurogenetics & Transcriptomics

NeuroRestorative Therapy

The NeuroRestorative Therapy Group investigates ways to restore neurological function in patients suffering from diseases that impact the human nervous system, through the development of novel multidisciplinary therapeutic strategies.

NeuroRestorative Therapy

Neurovascular Injury & Repair

The Neurovascular Injury & Repair group provides a forum to discuss novel concepts and mechanisms in disorders of the neurovascular unit. Emphasis is placed on the causes of neurovascular injury and repair/response mechanisms in diseases of the central or peripheral nervous system.


Protein Aggregation & Neurodegeneration

The Protein Aggregation & Neurodegeneration Group represents the most formalized of the Hope Center Research groups, HPAN. HPAN’s goal is to develop better ways to diagnose and treat neurodegenerative diseases through an understanding of the underlying molecular mechanisms that lead to protein aggregation and disease.

Protein Aggregation & Neurodegeneration