The principal focus of the laboratory is the molecular genetics of neuropsychiatric diseases. Major research areas include Alzheimer’s disease, nicotine addiction, and alcohol abuse. Alzheimer’s disease (AD), the most common neurodegenerative disease in the U.S., affecting over 4 million people over the age of 65 years. Current medications treat the symptoms but not the underlying causes of disease. There is therefore an urgent need to understand the underlying pathogenic mechanisms of disease to enable rational drug design. Long-term smoking has similar societal costs: it is the leading preventable cause of cancers and of premature mortality, with approximately one billion smoking-related deaths projected globally, based on present trends, in the current century. In addition to these areas of interest, genetics projects are underway on rare dementias.