News & Publications for:

Paul Kotzbauer

APOE genotype regulates pathology and disease progression in synucleinopathy

Posted on February 20, 2020

Albert A. Davis, Casey E. Inman, Zachary M. Wargel, Umber Dube, Brittany M. Freeberg, Alexander Galluppi, Jessica N. Haines, Dhruva D. Dhavale, Rebecca Miller, Fahim A. Choudhury, Patrick M. Sullivan, Carlos Cruchaga, Joel S. Perlmutter, Jason D. Ulrich, Bruno A. Benitez, Paul T. Kotzbauer and David M. Holtzman. Science Translational Medicine, Volume 12, Issue 529, 5 February 2020 Read More

Posted in: Clocks & Sleep, HPAN, Neurodegeneration, Neurogenetics & Transcriptomics, Publications Faculty: , , , ,

Detection of TAR DNA-binding protein 43 (TDP-43) oligomers as initial intermediate species during aggregate formation

Posted on May 17, 2019

Rachel L. French, Zachary R. Grese, Himani Aligireddy, Dhruva D. Dhavale, Ashley N. Reeb, Niraja Kedia, Paul T. Kotzbauer, Jan Bieschke and Yuna M. Ayala. Journal of Biological Chemistry, Volume 294, Issue 17, 2019, Pages 6696-6709 Read More

Posted in: HPAN, Neurodegeneration, Publications Faculty: ,

Parkinson’s disease and multiple system atrophy have distinct -synuclein seed characteristics

Posted on February 1, 2019

Tritia R. Yamasak, Brandon B. Holmes, Jennifer L. Furman, Dhruva D. Dhavale, Bryant W. Su, Eun-Suk Song, Nigel J. Cairns, Paul T. Kotzbauer and Marc I. Diamond. Journal of Biological Chemistry, Volume 294, Issue 3, 2019, Pages 1045-1058 Read More

Posted in: HPAN, Neurodegeneration, Publications Faculty: ,

Chalcones and Five-Membered Heterocyclic Isosteres Bind to Alpha Synuclein Fibrils in Vitro

Posted on May 11, 2018

Chia-Ju Hsieh, Kuiying Xu, Iljung Lee, Thomas J. A. Graham, Zhude Tu, Dhruva Dhavale, Paul Kotzbauer, and Robert H. Mach. ACS Omega, Volume 3, Issue 4, 2018, Pages 4486-4493 Read More

Posted in: HPAN, Neurodegeneration, Publications Faculty:

Resonance assignments of an α-synuclein fibril prepared in Tris buffer at moderate ionic strength

Posted on April 13, 2018

Alexander M. Barclay, Dhruva D. Dhavale, Joseph M. Courtney, Paul T. Kotzbauer, Chad M. Rienstra. Biomolecular NMR Assignments, Volume 12, Issue 1, 1 April 2018, Pages 195-199 Read More

Posted in: HPAN, Neurodegeneration, Publications Faculty: