News & Publications for:

Thomas Brett

Functional insights from biophysical study of TREM2 interactions with apoE and Aβ1‐42

Posted on November 4, 2020

Daniel L. Kober, Melissa D. Stuchell‐Brereton, Colin E. Kluender, Hunter B. Dean, Michael R. Strickland, Deborah F. Steinberg, Samantha S. Nelson, Berevan Baban, David M. Holtzman, Carl Frieden, Jennifer Alexander‐Brett, Erik D. Roberson, Yuhua Song, Tom J. Brett. Alzheimers Dementia. 2020 Oct 8 Read More

Posted in: HPAN, Neurodegeneration, Publications Faculty: , ,

Structural and Biophysical Analysis of the CLCA1 VWA Domain Suggests Mode of TMEM16A Engagement

Posted on February 13, 2020

Kayla N. Berry, Tom J. Brett. Cell Reports, Volume 30, Issue 4, 28 January 2020, Pages 1141-1151.e3 Read More

Posted in: HPAN, Neurodegeneration, Publications Faculty:

The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer’s disease risk

Posted on August 21, 2019

Yuetiva Deming, Fabia Filipello, Francesca Cignarella, Claudia Cantoni, Simon Hsu, Robert Mikesell, Zeran Li, Jorge L Del-Aguila, Umber Dube, Fabiana Geraldo Farias, Joseph Bradley, John Budde, Laura Ibanez, Maria Victoria Fernandez, Kaj Blennow, Henrik Zetterberg, Amanda Heslegrave, Per M Johansson, Johan Svensson, Bengt Nellgård, Alberto Lleo, Daniel Alcolea, Jordi Clarimon, Lorena Rami, José Luis Molinuevo, Marc Suárez-Calvet, Estrella Morenas-Rodríguez, Gernot Kleinberger, Michael Ewers, Oscar Harari, Christian Haass, Thomas J Brett, Bruno A. Benitez, Celeste M. Karch, Laura Piccio and Carlos Cruchaga. Science Translational Medicine, Vol 11, Issue 505,14 August 2019 Read More

Posted in: Axon Injury & Repair, HPAN, Lysosome, Neurodegeneration, Neurogenetics & Transcriptomics, Publications Faculty: , , , ,

The Ebola Viral Protein 35 N-Terminus Is a Parallel Tetramer

Posted on January 31, 2019

Chamnongsak Ken Chanthamontri, David S. Jordan, Wenjie Wang, Chao Wu , Yanchun Lin, Tom J. Brett, Michael L. Gross , and Daisy W. Leung. Biochemistry 2019 Read More

Posted in: HPAN, Neurodegeneration, Publications Faculty:

TREM2-ligand interactions in health and disease

Posted on June 9, 2017

Daniel L. Kober, Tom J. Brett. J. Mol. Biol., Volume 429, Issue 11, 2 June 2017, Pages 1607-1629 Read More

Posted in: HPAN, Neurodegeneration, Publications Faculty: