Complex biological networks control a range of functions in the human body from metabolic processes to the sleep cycle. Though scientists have ever-increasing volumes of data about the effects these complex systems produce, fully describing them mathematically has proven difficult. Without a firm understanding, effective interventions continue to be elusive, leaving more than 50 million […]
Human brain diseases, such as Parkinson’s disease, involve damage in more than one region of the brain, requiring technology that could precisely and flexibly address all affected regions simultaneously. Researchers at Washington University in St. Louis have developed a noninvasive technology combining a holographic acoustic device with genetic engineering that allows them to precisely target […]
The one-year awards promote collaborative research within the university
The research by Phil Bayly’s lab makes cover of Journal of the Acoustical Society of America
For the past several years, Washington University in St. Louis researchers have been using focused ultrasound combined with microbubbles to target an opening in the tough, protective blood-brain barrier to deliver drugs or retrieve biomarkers. To ensure that the fast-developing technology functions safely and consistently, Hong Chen, PhD, and her team, including first author and […]
Hong Chen, Jon Silva, both in biomedical engineering, are honored as rising leaders in their fields
High-tech imaging tool could be used in other medical fields
Chakrabarty, Cirrito to develop test with $3.6 million grant from Flu Lab
Rohit Pappu, collaborators from Duke University make discovery with model fungus
Rohit Pappu, collaborators find networking afforded by interactions among RNA molecules can enable different phase behavior when heating or cooling
Chao Zhou develops novel biophotonic technologies for ophthalmology, developmental biology, tissue engineering
WashU and St. Jude groups uncover the rules for organization of cellular condensates implicated in ALS
Rohit V. Pappu, PhD, an internationally renowned researcher in biomolecular condensates and intrinsically disordered proteins, was installed Oct. 9 as the Gene K. Beare Distinguished Professor of Biomedical Engineering at Washington University in St. Louis. Pappu is a professor of biomedical engineering and director of the Center for Biomolecular Condensates at the McKelvey School of […]
Song Hu plans to develop deep-brain fiber-optic techniques to investigate the cause of memory loss in Alzheimer’s disease
Mechanical engineers find brain’s vulnerability to head motion depends on direction and frequency, not just impact strength
Researchers have developed methods to study and manipulate areas of the brain, though many of those methods are restricted by the limited depth that light can reach within the brain. A multidisciplinary team at Washington University in St. Louis plans to overcome that limitation by integrating ultrasound with genetics to precisely modify neurons in the […]
Now that the emergency phase of the COVID-19 pandemic has ended, scientists are looking at ways to surveil indoor environments in real time for viruses. By combining recent advances in aerosol sampling technology and an ultrasensitive biosensing technique, researchers at Washington University in St. Louis have created a real-time monitor that can detect any of […]
Intrinsically disordered proteins (IDPs) are defined by structural diversity, and the determinants of this diversity are an important area of biophysical investigation. IDPs are involved in a range of important biological processes, including cell signaling and regulation, that allow healthy cells to respond to environmental factors appropriately, but they are also associated with human diseases […]
Research from labs of Rohit Pappu, collaborators sheds light on condensate characteristics
Song Hu, Yong Wang team up to find quantitative biomarkers for clinical pain management
Our brains consume huge amounts of energy and rely on oxygen supplied by blood vessels. When the brains of infants are deprived of oxygen for any reason, it can lead to brain injury that causes cerebral palsy, epilepsy or cognitive impairment. Song Hu, PhD, associate professor of biomedical engineering in the McKelvey School of Engineering […]
Hong Chen’s lab develops technique to generate Airy beams for ultrasound focusing
Epilepsy is a neurological disorder that arises from abnormal electrical activity in the brain leading to seizures. These seizure events can have a variety of causes, including genetic variants in a family of proteins that regulate potassium ions in the brain. Researchers at Washington University in St. Louis have led an international team to take […]
ShiNung Ching, collaborators seek to develop predictive model for secondary brain injuries
Song Hu combines hardware and machine learning for precision imaging technique
A submarine can inadvertently reveal its location because of cavitation, a condition that creates bubbles underwater that burst, then emit sound waves that can be detected by sonar. A team of biomedical engineers at Washington University in St. Louis plans to use the same concept to detect cavitation in human brains that may contribute to […]
Philip Bayly, collaborators to use imaging, modeling to look at waves in the brain
Hong Chen’s lab created an $80 device that is accurate and easy to use
Hong Chen, medical school faculty to collaborate on NIH-funded work
Song Hu, Lan Yang, Jin-Moo Lee, MD, PhD collaborate on NIH-funded work
Jai Rudra, Meredith Jackrel to use nanofibers to develop new vaccines
It is the first work to show that sonothermogenetics can control behavior by stimulating a specific target deep in the brain
Dezhuang Ye in Hong Chen’s lab tests novel method in brain tumor model