Scientists trying to understand the physical and chemical properties that govern biomolecular condensates now have a crucial way to measure pH and other emergent properties of these enigmatic, albeit important cellular compartments. Condensates are communities of proteins and nucleic acids. They lack a membrane and come together and fall apart as needed. The nucleolus is […]
Sarah D. Ackerman, PhD, Gabor Egervari, MD, PhD and Tao Xie, PhD, all of Washington University School of Medicine in St. Louis, have been named 2023 Young Investigator grantees by the Brain & Behavior Research Foundation. This year’s funding will support 150 promising early-career scientists across the field of neuropsychiatry with innovative ideas in mental health research. The two-year grant […]
Rohit Pappu, collaborators find networking afforded by interactions among RNA molecules can enable different phase behavior when heating or cooling
WashU and St. Jude groups uncover the rules for organization of cellular condensates implicated in ALS
Jason Yi, PhD, an assistant professor of neuroscience, and Harrison Gabel, PhD, an associate professor of neuroscience, both at Washington University School of Medicine in St. Louis, each have received two-year $300,000 pilot grants from the Simons Foundation Autism Research Initiative. The researchers will use the funds to investigate genetic diseases that result in autism. […]
Intrinsically disordered proteins (IDPs) are defined by structural diversity, and the determinants of this diversity are an important area of biophysical investigation. IDPs are involved in a range of important biological processes, including cell signaling and regulation, that allow healthy cells to respond to environmental factors appropriately, but they are also associated with human diseases […]
The National Institutes of General Medical Sciences has awarded an Outstanding Investigator Award of nearly $2 million to Paul Taghert, PhD, Professor of Neuroscience at Washington University School of Medicine, to study how the circadian clock orchestrates multiple biological cycles that operate at different phases. Physiological and behavioral rhythms, such as sleep, hormone fluxes, and eating, […]
Jonathan D. Cooper, PhD, a professor of pediatrics, of genetics and of neurology at the Washington University School of Medicine in St. Louis, received two grants totaling $2.55 million over five years from the National Institute of Neurological Disorders and Stroke of the National Institutes of Health (NIH). Cooper will study enzyme replacement therapy as a possible […]
Research from labs of Rohit Pappu, collaborators sheds light on condensate characteristics
Anuradhika Puri, PhD, a postdoctoral research associate working with Meredith Jackrel, PhD in the Department of Chemistry in Arts & Sciences at Washington University in St. Louis, won the Amyotrophic Lateral Sclerosis Association’s Milton Safenowitz Postdoctoral Fellowship. The $150,000 award supports her work on applying the human disaggregase, HtrA1, to counter amyotrophic lateral sclerosis, or ALS. Originally published on […]
Four years after Washington University in St. Louis researchers detected a possible link between risk for Alzheimer’s disease and the appearance of the eye’s retina, a $10.3 million grant from the National Institute on Aging of the National Institutes of Health (NIH) is expanding the effort to understand that connection. Gregory P. Van Stavern, MD, […]
Song Hu, Yong Wang team up to find quantitative biomarkers for clinical pain management
Hong Chen’s lab develops noninvasive focused ultrasound intranasal delivery method
For animals such as mice, olfaction is their primary route to pick up social information, whether that’s identifying the dominant male in a group or figuring out the reproductive status of females. In turn, these signals can influence animals’ behavior and physiology. Pheromones in male urine, for instance, can trigger early puberty in mice. While […]
Intrinsically disordered regions (IDRs) of proteins, when tethered to folded domains, function either as flexible tails or as linkers between domains. Most IDRs are composed of a mixture of oppositely charged residues. Recent measurements of tethered polyampholytes have shown that arginine- and lysine-rich sequences tend to behave very differently from one another. In a paper […]
$3.5M grant from NIH
Multiyear, multi-million-dollar grant
Two-year $300,000 grant
Three-year $225,000 grant
The grants are awarded by the National Institutes of Health (NIH)
Five-year $2 million grant from NIH
Five-year $2.3 million grant
Five-year $2.5 million grant from NIH
Three-year $1.1 million grant from CDI
Three-year and two-year grants totaling $2.4M
Four-year and one-year grants totaling $3.3M
$300,000 award
Two-year $486,844 grant from Brigham and Women’s Hospital and a two-year $345,000 grant from the Cure Alzheimer’s Fund
Finding prompts researchers, clinicians to consider impact in future research, clinical treatment of brain diseases
Four-year $2.09 million R01 research grant
Three-year $136,560 National Research Service Award