Chen awarded two Scialog grants to study the molecular basis of cognition

Yao Chen, PhD, an assistant professor of neuroscience at Washington University School of Medicine in St. Louis, is part of two teams that have been awarded grants to study the molecular processes that underlie memory and cognition. The grants are part of the “Research Corporation for Science Advancement’s Scialog: Molecular Basis of Cognition” initiative. The […]

Understanding role of T cells in Alzheimer’s disease is aim of new grant

There is increasing evidence that the immune system is involved in the development and progression of Alzheimer’s disease. Most research has focused on the innate immune system and its role in mediating neuroinflammation and degeneration. Naresha Saligrama, PhD, an assistant professor of neurology at Washington University School of Medicine in St. Louis, has received a […]

Some brain tumors may be linked to head injury, mouse study suggests

A study in mice by researchers at the School of Medicine indicates that brain injury can lead to brain tumors in susceptible individuals. For this study, they used mice that model people with neurofibromatosis type 1 (NF1), a genetic disorder that causes brain tumors. The study showed that molecules released by injured neurons set off […]

Nine School of Medicine researchers receive Longer Life grants

Nine researchers at Washington University School of Medicine in St. Louis have received funding from the Longer Life Foundation — a cooperative effort between the School of Medicine and the Reinsurance Group of America. The foundation supports research aimed at improving human health, wellness and longevity.  The researchers are:  Originally published on The Source.

WashU engineers manage a first: measuring pH in cell condensates

Scientists trying to understand the physical and chemical properties that govern biomolecular condensates now have a crucial way to measure pH and other emergent properties of these enigmatic, albeit important cellular compartments. Condensates are communities of proteins and nucleic acids. They lack a membrane and come together and fall apart as needed. The nucleolus is […]

Three named 2023 Young Investigator grantees

Sarah D. Ackerman, PhD, Gabor Egervari, MD, PhD and Tao Xie, PhD, all of Washington University School of Medicine in St. Louis, have been named 2023 Young Investigator grantees by the Brain & Behavior Research Foundation. This year’s funding will support 150 promising early-career scientists across the field of neuropsychiatry with innovative ideas in mental health research. The two-year grant […]

Yi and Gabel receive grants to study autism-related disorders

Jason Yi, PhD, an assistant professor of neuroscience, and Harrison Gabel, PhD, an associate professor of neuroscience, both at Washington University School of Medicine in St. Louis, each have received two-year $300,000 pilot grants from the Simons Foundation Autism Research Initiative. The researchers will use the funds to investigate genetic diseases that result in autism. […]

Pappu to explore ways in which charge contributes to diverse states of proteins

Intrinsically disordered proteins (IDPs) are defined by structural diversity, and the determinants of this diversity are an important area of biophysical investigation. IDPs are involved in a range of important biological processes, including cell signaling and regulation, that allow healthy cells to respond to environmental factors appropriately, but they are also associated with human diseases […]

Paul Taghert awarded $1.9 million Outstanding Investigator Award

The National Institutes of General Medical Sciences has awarded an Outstanding Investigator Award of nearly $2 million to Paul Taghert, PhD, Professor of Neuroscience at Washington University School of Medicine, to study how the circadian clock orchestrates multiple biological cycles that operate at different phases. Physiological and behavioral rhythms, such as sleep, hormone fluxes, and eating, […]

Cooper receives two NIH grants to study rare genetic disease

Jonathan D. Cooper, PhD,  a professor of pediatrics, of genetics and of neurology at the Washington University School of Medicine in St. Louis, received two grants totaling $2.55 million over five years from the National Institute of Neurological Disorders and Stroke of the National Institutes of Health (NIH).  Cooper will study enzyme replacement therapy as a possible […]

Puri wins postdoctoral fellowship to study ALS

Anuradhika Puri, PhD, a postdoctoral research associate working with Meredith Jackrel, PhD in the Department of Chemistry in Arts & Sciences at Washington University in St. Louis, won the Amyotrophic Lateral Sclerosis Association’s Milton Safenowitz Postdoctoral Fellowship. The $150,000 award supports her work on applying the human disaggregase, HtrA1, to counter amyotrophic lateral sclerosis, or ALS. Originally published on […]

Researchers studying links between retinal appearance, Alzheimer’s

Four years after Washington University in St. Louis researchers detected a possible link between risk for Alzheimer’s disease and the appearance of the eye’s retina, a $10.3 million grant from the National Institute on Aging of the National Institutes of Health (NIH) is expanding the effort to understand that connection. Gregory P. Van Stavern, MD, […]

Holy awarded grant to study mouse pheromones

For animals such as mice, olfaction is their primary route to pick up social information, whether that’s identifying the dominant male in a group or figuring out the reproductive status of females. In turn, these signals can influence animals’ behavior and physiology. Pheromones in male urine, for instance, can trigger early puberty in mice. While […]

Pappu lab untangles more IDR secrets

Intrinsically disordered regions (IDRs) of proteins, when tethered to folded domains, function either as flexible tails or as linkers between domains. Most IDRs are composed of a mixture of oppositely charged residues. Recent measurements of tethered polyampholytes have shown that arginine- and lysine-rich sequences tend to behave very differently from one another. In a paper […]

Yoo wins research grants

Two-year $486,844 grant from Brigham and Women’s Hospital and a two-year $345,000 grant from the Cure Alzheimer’s Fund