Pediatric pilocytic astrocytoma (PA) is a common type of low-grade brain tumor in children, influenced by specific genetic changes. Led by David H. Gutmann, MD, PhD, the Donald O. Schnuck Family Professor of Neurology, researchers at WashU Medicine have conducted a study, published in Genes & Development, using advanced stem cell techniques to investigate the genetic […]
The National Institutes of Health (NIH) is supporting a WashU Medicine effort to track neuroinflammation in the brains of patients with Parkinson’s disease. The five-year $3 million grant will allow co-principal investigators Zhude (Will) Tu, PhD, a professor of radiology, and Joel S. Perlmutter, MD, a professor of neurology and of radiology, to use radiotracers to track […]
The Jansky/Bander Family Fund, a generous commitment of $1.1 million over five years, has been established to advance critical initiatives within the Section of Movement Disorders in the Department of Neurology at WashU Medicine. This significant financial contribution is earmarked for two primary functions under the direction of Joel S. Perlmutter, MD: funding fellowships and supporting […]
Five researchers from Washington University in St. Louis have been named senior members of the National Academy of Inventors (NAI). Among the new senior members are three researchers from the School of Medicine: Rajendra Apte, MD, PhD, Aaron DiAntonio, MD PhD, and John DiPersio, MD, PhD; along with Sophia Hayes, PhD, a professor of chemistry […]
Washington University in St. Louis’ Research Development Office recently awarded its latest batch of “Here and Next” Seed Grants. The winning research teams are interdisciplinary and focus on five key elements of the university’s strategic plan: public health, global health, environmental research, digital transformation and research that impacts the St. Louis community. There are three […]
Andrew Yoo, PhD, a professor of developmental biology at WashU Medicine, has received the 2024 Transformative Research Award, a two-year $1 million grant from the Hereditary Disease Foundation. Yoo and his collaborator, Osama Al Dalahmah, MD, PhD, of Columbia University, will use this support to pursue potential therapeutics for Huntington’s disease, an inherited neurodegenerative disorder […]
Sheng Chih (Peter) Jin, PhD, an assistant professor of genetics at WashU Medicine, has received a $3.2 million grant from the National Institute of Neurological Disorders and Stroke of the National Institutes of Health (NIH) to study the genetic and molecular underpinnings of congenital hydrocephalus, a buildup of too much cerebrospinal fluid in the brain […]
Guoyan Zhao, PhD, an assistant professor of genetics and of neurology, and Erik Musiek, MD, PhD, the Charlotte & Paul Hagemann Professor of Neurology, both of WashU Medicine, have received a $433,000 grant from the National Institute on Aging of the National Institutes of Health (NIH) to study brain cells called astrocytes and their roles […]
Washington University School of Medicine faculty members Mark Rutherford and Yang E. Li have won grants from St. Baldrick’s Foundation to study pediatric cancers.
Scientists at the McKelvey School of Engineering at Washington University in St. Louis sort the rules governing putty-like biomolecular condensates.
Researchers at Washington University School of Medicine in St. Louis have shown how brain tumors evolve in response to therapy, helping describe how such cancers develop treatment resistance that leads to the high mortality rate characteristic of this cancer. Only 5% of patients survive five years after diagnosis with the most aggressive brain cancers. Published […]
Yao Chen, PhD, an assistant professor of neuroscience at Washington University School of Medicine in St. Louis, is part of two teams that have been awarded grants to study the molecular processes that underlie memory and cognition. The grants are part of the “Research Corporation for Science Advancement’s Scialog: Molecular Basis of Cognition” initiative. The […]
There is increasing evidence that the immune system is involved in the development and progression of Alzheimer’s disease. Most research has focused on the innate immune system and its role in mediating neuroinflammation and degeneration. Naresha Saligrama, PhD, an assistant professor of neurology at Washington University School of Medicine in St. Louis, has received a […]
A study in mice by researchers at the School of Medicine indicates that brain injury can lead to brain tumors in susceptible individuals. For this study, they used mice that model people with neurofibromatosis type 1 (NF1), a genetic disorder that causes brain tumors. The study showed that molecules released by injured neurons set off […]
Nine researchers at Washington University School of Medicine in St. Louis have received funding from the Longer Life Foundation — a cooperative effort between the School of Medicine and the Reinsurance Group of America. The foundation supports research aimed at improving human health, wellness and longevity. The researchers are: Originally published on The Source.
Scientists trying to understand the physical and chemical properties that govern biomolecular condensates now have a crucial way to measure pH and other emergent properties of these enigmatic, albeit important cellular compartments. Condensates are communities of proteins and nucleic acids. They lack a membrane and come together and fall apart as needed. The nucleolus is […]
Sarah D. Ackerman, PhD, Gabor Egervari, MD, PhD and Tao Xie, PhD, all of Washington University School of Medicine in St. Louis, have been named 2023 Young Investigator grantees by the Brain & Behavior Research Foundation. This year’s funding will support 150 promising early-career scientists across the field of neuropsychiatry with innovative ideas in mental health research. The two-year grant […]
Rohit Pappu, collaborators find networking afforded by interactions among RNA molecules can enable different phase behavior when heating or cooling
WashU and St. Jude groups uncover the rules for organization of cellular condensates implicated in ALS
Jason Yi, PhD, an assistant professor of neuroscience, and Harrison Gabel, PhD, an associate professor of neuroscience, both at Washington University School of Medicine in St. Louis, each have received two-year $300,000 pilot grants from the Simons Foundation Autism Research Initiative. The researchers will use the funds to investigate genetic diseases that result in autism. […]
Intrinsically disordered proteins (IDPs) are defined by structural diversity, and the determinants of this diversity are an important area of biophysical investigation. IDPs are involved in a range of important biological processes, including cell signaling and regulation, that allow healthy cells to respond to environmental factors appropriately, but they are also associated with human diseases […]
The National Institutes of General Medical Sciences has awarded an Outstanding Investigator Award of nearly $2 million to Paul Taghert, PhD, Professor of Neuroscience at Washington University School of Medicine, to study how the circadian clock orchestrates multiple biological cycles that operate at different phases. Physiological and behavioral rhythms, such as sleep, hormone fluxes, and eating, […]
Jonathan D. Cooper, PhD, a professor of pediatrics, of genetics and of neurology at the Washington University School of Medicine in St. Louis, received two grants totaling $2.55 million over five years from the National Institute of Neurological Disorders and Stroke of the National Institutes of Health (NIH). Cooper will study enzyme replacement therapy as a possible […]
Research from labs of Rohit Pappu, collaborators sheds light on condensate characteristics
Anuradhika Puri, PhD, a postdoctoral research associate working with Meredith Jackrel, PhD in the Department of Chemistry in Arts & Sciences at Washington University in St. Louis, won the Amyotrophic Lateral Sclerosis Association’s Milton Safenowitz Postdoctoral Fellowship. The $150,000 award supports her work on applying the human disaggregase, HtrA1, to counter amyotrophic lateral sclerosis, or ALS. Originally published on […]
Four years after Washington University in St. Louis researchers detected a possible link between risk for Alzheimer’s disease and the appearance of the eye’s retina, a $10.3 million grant from the National Institute on Aging of the National Institutes of Health (NIH) is expanding the effort to understand that connection. Gregory P. Van Stavern, MD, […]
Song Hu, Yong Wang team up to find quantitative biomarkers for clinical pain management
Hong Chen’s lab develops noninvasive focused ultrasound intranasal delivery method
For animals such as mice, olfaction is their primary route to pick up social information, whether that’s identifying the dominant male in a group or figuring out the reproductive status of females. In turn, these signals can influence animals’ behavior and physiology. Pheromones in male urine, for instance, can trigger early puberty in mice. While […]
Intrinsically disordered regions (IDRs) of proteins, when tethered to folded domains, function either as flexible tails or as linkers between domains. Most IDRs are composed of a mixture of oppositely charged residues. Recent measurements of tethered polyampholytes have shown that arginine- and lysine-rich sequences tend to behave very differently from one another. In a paper […]
$3.5M grant from NIH
Multiyear, multi-million-dollar grant
Two-year $300,000 grant
Three-year $225,000 grant
The grants are awarded by the National Institutes of Health (NIH)
Five-year $2 million grant from NIH
Five-year $2.3 million grant
Five-year $2.5 million grant from NIH
Three-year $1.1 million grant from CDI
Three-year and two-year grants totaling $2.4M
Four-year and one-year grants totaling $3.3M
$300,000 award
Two-year $486,844 grant from Brigham and Women’s Hospital and a two-year $345,000 grant from the Cure Alzheimer’s Fund
Finding prompts researchers, clinicians to consider impact in future research, clinical treatment of brain diseases
Four-year $2.09 million R01 research grant
Three-year $136,560 National Research Service Award