More research needed to determine if sleep medications prevent, delay Alzheimer’s
Sleeping pill reduces levels of Alzheimer’s proteins
Category: Neurodegeneration/HPAN
Discovery of T cells’ role in Alzheimer’s, related diseases, suggests new treatment strategy
Findings, in mice, open up drug development possibilities for brain diseases linked to tau protein
Miller receives Rainwater Prize for Brain Research
Honored for work developing new kind of therapy for neurodegenerative diseases
Jackrel awarded grant to study proteins linked to ALS and frontotemporal dementia
Funding from the National Institutes of Health will help Jackrel and her team study Matrin-3, a poorly understood protein linked to several neurodegenerative disorders.
Focused ultrasound technique leads to release of neurodegenerative disorders biomarkers
Research could facilitate diagnosis of Alzheimer’s disease
Interfaces play important role in condensate behavior
Research from labs of Rohit Pappu, collaborators sheds light on condensate characteristics
Gut bacteria affect brain health, mouse study shows
Findings suggest new approach to treating Alzheimer’s, other neurodegenerative diseases
Future Thoughts and Reason for Excitement in ALS: Timothy Miller, MD, PhD
“These trials don’t go without huge input and commitment from the participants and of course, their caregivers, and the clinical trial sites. I have the privilege of speaking to you about the trial as the lead author of this paper, but this is a team effort and includes a large group of people from multiple […]
Study yields clues to why Alzheimer’s disease damages certain parts of the brain
Findings could help explain rare symptoms such as problems with language, vision
Rejuvenated immune cells can improve clearance of toxic waste from brain
Findings in mice suggest new therapeutic approach to Alzheimer’s, other age-related diseases
Center for Biomolecular Condensates launches
Symposium brings together key leaders in the field
What causes Alzheimer’s? Study puts leading theory to ‘ultimate test’
An idea that has propelled Alzheimer’s research for more than 30 years is approaching its day of reckoning. Scientists are launching a study designed to make or break the hypothesis that Alzheimer’s is caused by a sticky substance called beta-amyloid. The study will give an experimental anti-amyloid drug to people as young as 18 who […]
Cellular housekeeping process implicated in fatal neurological disorder
Neurons made from Huntington’s disease patients’ skin cells shed light on cognitive decline
Multi-scale imaging technique may enable objective assessment of myofascial pain
Song Hu, Yong Wang team up to find quantitative biomarkers for clinical pain management
$9 million to fund study of ‘jumping genes’ in Alzheimer’s
Researchers from several labs to study role of transposable elements
Scientists ID pathway that triggers mice to scratch when they see others do the same
Behavior surprisingly does not require brain’s visual cortex
Investigational drug for genetic form of ALS improves disease’s molecular signs
Extended use of tofersen may help stabilize muscle strength, control
How do cells take out the trash?
Research uncovers how unfolded proteins are discarded, and how a perfectly good protein can wind up in the trash
High-tech imaging focuses on oxygen metabolism in newborn brain
Our brains consume huge amounts of energy and rely on oxygen supplied by blood vessels. When the brains of infants are deprived of oxygen for any reason, it can lead to brain injury that causes cerebral palsy, epilepsy or cognitive impairment. Song Hu, PhD, associate professor of biomedical engineering in the McKelvey School of Engineering […]
Study points to new approach to clearing toxic waste from brain
Could aid efforts to find treatments for Alzheimer’s, other diseases
A one-two punch for photoacoustic imaging
Song Hu combines hardware and machine learning for precision imaging technique
New center’s aim: To ID biomarkers of neurodegenerative diseases
A new center established at Washington University School of Medicine in St. Louis aims to accelerate research into biomarkers of neurodegenerative conditions such as Huntington’s and Parkinson’s diseases, amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS) and the so-called tauopathies, a group that includes Alzheimer’s disease along with rarer diseases such as frontotemporal dementia, corticobasal syndrome […]
New structure found in cells
Every cell contains millions of protein molecules. Some of them have the ability to phase-separate to form non-membrane-bound compartments, called biomolecular condensates, inside a cell. It has long been assumed that there was no further structure underlying these condensates, only solution-soluble proteins. A research group led by Rohit Pappu, PhD, the Gene K. Beare Distinguished Professor […]
Gut bacteria mine dietary fiber to release beneficial nutrients
A new study from Washington University School of Medicine in St. Louis demonstrates that certain human gut microbes can mine dietary fiber to extract nutrients that otherwise would remain inaccessible to the human body. The study, published June 27 in the journal Cell, illustrates how the fiber byproducts of food production — such as rinds, peels […]
Pappu lab untangles more IDR secrets
Intrinsically disordered regions (IDRs) of proteins, when tethered to folded domains, function either as flexible tails or as linkers between domains. Most IDRs are composed of a mixture of oppositely charged residues. Recent measurements of tethered polyampholytes have shown that arginine- and lysine-rich sequences tend to behave very differently from one another. In a paper […]
Neural pathway key to sensation of pleasant touch identified
Similar to itch, pleasant touch transmitted by specific neuropeptide and neural circuit
Race of people given Alzheimer’s blood tests may affect interpretation of results
3 of 4 tests performed inconsistently across racial groups
Risky driving behaviors increase as common sleep disorder worsens
Diagnosing, treating sleep apnea may make driving safer for older adults
Risk, resiliency in aging brain focus of $33 million grant
Multicenter team aims to understand how, why brain changes with age
Blood test for Alzheimer’s highly accurate in large, international study
When combined with genetic risk factors, test up to 93% accurate at identifying people at risk of Alzheimer’s dementia
Li receives Whitehall grant
Three-year $225,000 grant
International team finds new mechanism critical for formation of membrane vesicles
These vesicles are critical for proper cell function
Mennerick receives NIH grant
Five-year $2.3 million grant
Less energy, better quality PAM images with machine learning
The two-step denoising technique was developed in Song Hu’s lab
Chen to study neurological disorders
Five-year $2.5 million grant from NIH
Saligrama to research pediatric onset multiple sclerosis
Three-year $1.1 million grant from CDI
International Alzheimer’s clinical trial to test two drugs in combination
Drugs targeting amyloid, tau to be evaluated together
Colonna receives NIH grants
Four-year and one-year grants totaling $3.3M
Hit the sleep ‘sweet spot’ to keep brain sharp
Too little and too much sleep linked to cognitive decline
$12.2 million to fund new Conte Center to study neurosteroids
Complements efforts of Taylor Family Institute to develop treatments for psychiatric illness
Time until dementia symptoms appear can be estimated via brain scan
Alzheimer’s dementia predicted by brain amyloid levels, age
‘Unprecedented opportunity’ to understand neurovascular recovery after stroke
Song Hu, Lan Yang, Jin-Moo Lee, MD, PhD collaborate on NIH-funded work
Schmidt recognized for contributions to neuropathology
Expert on peripheral nervous system honored for work as educator, clinician, researcher
NIH funds Rudra, Jackrel to improve vaccines for elderly
Jai Rudra, Meredith Jackrel to use nanofibers to develop new vaccines
New Alzheimer’s treatment targets identified
Study points to FDA-approved drugs that have potential to slow or reverse brain damage
Lee named head of Department of Neurology
Recognized for expertise in brain injury, impact as mentor
Protein linked to heart health, disease a potential therapeutic target for dementia
Brain protein reduces Alzheimer’s-like brain damage in mice
Investigational Alzheimer’s drug improves biomarkers of the disease
International clinical trial yields mixed results with unclear cognitive effects but promising biomarker results
Immunologist joins Colonna lab as Pew Latin American Fellow
Fachi will study role of healthy gut bacteria in immunity
Studies reveal skull as unexpected source of brain immunity
Immune cells from skull bone marrow guard the brain, spinal cord