Gut bacteria boost immune response to fight tumors

Roughly one in five cancer patients benefits from immunotherapy – a treatment that harnesses the immune system to fight cancer. Such an approach to beating cancer has seen significant success in lung cancer and melanoma, among others. Optimistic about its potential, researchers are exploring strategies to improve immunotherapy for cancers that don’t respond well to […]

Some brain tumors may be linked to head injury, mouse study suggests

A study in mice by researchers at the School of Medicine indicates that brain injury can lead to brain tumors in susceptible individuals. For this study, they used mice that model people with neurofibromatosis type 1 (NF1), a genetic disorder that causes brain tumors. The study showed that molecules released by injured neurons set off […]

Diwan named inaugural Shaeffer professor

Abhinav Diwan, MD, a highly regarded cardiologist with expertise in the molecular underpinnings of cardiovascular disease, has been named the inaugural Charlie W. Shaeffer, MD, Professor of Cardiology at Washington University School of Medicine in St. Louis. Diwan was installed by David H. Perlmutter, MD, executive vice chancellor for medical affairs, the George and Carol […]

Nine School of Medicine researchers receive Longer Life grants

Nine researchers at Washington University School of Medicine in St. Louis have received funding from the Longer Life Foundation — a cooperative effort between the School of Medicine and the Reinsurance Group of America. The foundation supports research aimed at improving human health, wellness and longevity.  The researchers are:  Originally published on The Source.

Saraswathy, Choi and Xu receive 2024 Hope Center Awards

Each year, the Hope Center for Neurological Disorders recognizes trainees (students and postdocs) who present their work at the Hope Center Retreat. Hope Center award winners are selected based on scientific merit, presentation, and projects that address the Hope Center mission. Congratulations to the winners of this year’s Hope Center Awards! Winner from the talks: Vishnu Muraleedharan Saraswathy, […]

Dickson, Khabele, Longmore elected to Association of American Physicians

Three physician-scientists at Washington University School of Medicine in St. Louis have been newly elected to the Association of American Physicians. Membership in the organization is an honor bestowed on physicians who lead innovative scientific research to improve health care. They are Patricia I. Dickson, MD, Dineo Khabele, MD, and Gregory D. Longmore, MD. Dickson, the Centennial Professor […]

Focused ultrasound technique gets quality assurance protocol

For the past several years, Washington University in St. Louis researchers have been using focused ultrasound combined with microbubbles to target an opening in the tough, protective blood-brain barrier to deliver drugs or retrieve biomarkers. To ensure that the fast-developing technology functions safely and consistently, Hong Chen, PhD, and her team, including first author and […]

Immunotherapy for Alzheimer’s disease shows promise in mouse study

Alzheimer’s disease starts with a sticky protein called amyloid beta that builds up into plaques in the brain, setting off a chain of events that results in brain atrophy and cognitive decline. The new generation of Alzheimer’s drugs — the first proven to change the course of the disease — work by tagging amyloid for […]

WashU engineers manage a first: measuring pH in cell condensates

Scientists trying to understand the physical and chemical properties that govern biomolecular condensates now have a crucial way to measure pH and other emergent properties of these enigmatic, albeit important cellular compartments. Condensates are communities of proteins and nucleic acids. They lack a membrane and come together and fall apart as needed. The nucleolus is […]

Neurons help flush waste out of brain during sleep

There lies a paradox in sleep. Its apparent tranquility juxtaposes with the brain’s bustling activity. The night is still, but the brain is far from dormant. During sleep, brain cells produce bursts of electrical pulses that cumulate into rhythmic waves — a sign of heightened brain cell function. But why is the brain active when we […]

Bypassing the blood-brain barrier to improve brain tumor diagnosis

First-in-human trial demonstrates safety of sonobiopsy in patients with glioma Getting a biopsy is often an important first step for cancer diagnosis and treatment. But brain tumors present unique challenges: to perform a biopsy, a neurosurgeon will likely need to drill into the skull, and removing brain tissue can cause complications, including bleeding, brain swelling, […]

Gordon receives Nemmers Prize

Jeffrey I. Gordon, MD, of Washington University School of Medicine in St. Louis, has received the 2024 Mechthild Esser Nemmers Prize in Medical Science from Northwestern University. Gordon was selected for the prize by a jury of distinguished U.S. scientists for transforming the understanding of human health and how it is shaped by the gut […]

Newly opened Jeffrey T. Fort Neuroscience Research Building dedicated

Dozens of noted scientists, philanthropists, and university, state and local leaders gathered Jan. 18 to celebrate the dedication of one of the world’s largest neuroscience research buildings, a gleaming state-of-the-art facility on the Washington University Medical Campus. They toured its sophisticated, newly christened labs; listened intently as Washington University scientists described the lifesaving work they […]

Scientists are beginning to understand how long COVID symptoms affect the brain

Many symptoms of long COVID are related to the brain. Now scientists are beginning to understand why brain fog, fatigue, and pain can linger for years after a person was infected. ARI SHAPIRO, HOST: Months or even years after getting COVID-19, some people still have neurological symptoms like pain, fatigue and brain fog. MICHELLE WILSON: […]

Three named 2023 Young Investigator grantees

Sarah D. Ackerman, PhD, Gabor Egervari, MD, PhD and Tao Xie, PhD, all of Washington University School of Medicine in St. Louis, have been named 2023 Young Investigator grantees by the Brain & Behavior Research Foundation. This year’s funding will support 150 promising early-career scientists across the field of neuropsychiatry with innovative ideas in mental health research. The two-year grant […]

Dickson installed as the Centennial Professor of Pediatrics

Patricia Dickson, MD, a professor of pediatrics, has been installed as the Centennial Professor of Pediatrics . A celebration to mark the event took place Thursday, Nov. 9, 2023 in the Eric P. Newman Education Center. Dickson earned an undergraduate degree from the University of Chicago in 1995 in Classics and her medical degree in 1999 […]

Cavalli, Klyachko receive grant to investigate hypersensitivity in Fragile X syndrome

Valeria Cavalli, PhD, the Robert E. and Louise F. Dunn Professor of Biomedical Research in the Department of Neuroscience at Washington University, has received a grant of more than $400,000 to understand the origins of hypersensitivity in Fragile X syndrome (FXS). This genetic disorder, which accounts for the most cases of autism by a known […]

Pappu installed as Gene K. Beare Distinguished Professor of Biomedical Engineering

Rohit V. Pappu, PhD, an internationally renowned researcher in biomolecular condensates and intrinsically disordered proteins, was installed Oct. 9 as the Gene K. Beare Distinguished Professor of Biomedical Engineering at Washington University in St. Louis. Pappu is a professor of biomedical engineering and director of the Center for Biomolecular Condensates at the McKelvey School of […]

Yi and Gabel receive grants to study autism-related disorders

Jason Yi, PhD, an assistant professor of neuroscience, and Harrison Gabel, PhD, an associate professor of neuroscience, both at Washington University School of Medicine in St. Louis, each have received two-year $300,000 pilot grants from the Simons Foundation Autism Research Initiative. The researchers will use the funds to investigate genetic diseases that result in autism. […]