News & Publications for:

Carlos Cruchaga

Alzheimer’s therapeutics targeting amyloid beta 1-42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicity

Posted on December 11, 2014

Nicholas J. Izzo, Jinbin Xu, Chenbo Zeng, Molly J. Kirk, Kelsie Mozzoni, Colleen Silky, Courtney Rehak, Raymond Yurko, Gary Look, Gilbert Rishton,Hank Safferstein, Carlos Cruchaga, Alison Goate, Michael A. Cahill, Ottavio Arancio, Robert H. Mach, Rolf Craven, Elizabeth Head, Harry LeVine III,Tara L. Spires-Jones, Susan M. Catalano; 2014, PLoS ONE, 9(11), Article number e111899 Read More

Posted in: HPAN, Neurodegeneration, Neurogenetics, Publications Faculty: ,

Coding variants in TREM2 increase risk for Alzheimer’s disease

Posted on December 11, 2014

Sheng Chih Jin, Bruno A. Benitez, Celeste M. Karch, Breanna Cooper, Tara Skorupa, David Carrell, Joanne B. Norton, Simon Hsu, Oscar Harari, Yefei Cai, Sarah Bertelsen, Alison M. Goate, and Carlos Cruchaga; 2014, Human Molecular Genetics, 23(21), p5835-5846 Read More

Posted in: Axon Injury & Repair, HPAN, Neurodegeneration, Neurogenetics, Publications Faculty: , ,

Genome-Wide Association Study of CSF Levels of 59 Alzheimer’s Disease Candidate Proteins: Significant Associations with Proteins Involved in Amyloid Processing and Inflammation

Posted on November 13, 2014

John S. K. Kauwe, Matthew H. Bailey, Perry G. Ridge, Rachel Perry, Mark E. Wadsworth, Kaitlyn L. Hoyt, Lyndsay A. Staley, Celeste M. Karch, Oscar Harari, Carlos Cruchaga, Benjamin J. Ainscough, Kelly Bales, Eve H. Pickering, Sarah Bertelsen, Anne M. Fagan, David M. Holtzman, John C. Morris, Alison M. Goate; 2014 PLoS Genetics, 10(10), DOI: 10.1371/journal.pgen.1004758 Read More

Posted in: Axon Injury & Repair, HPAN, Neurodegeneration, Neurogenetics, Publications Faculty: , , , , ,

Variants in PPP3R1 and MAPT are associated with more rapid functional decline in Alzheimer’s disease: The Cache County Dementia Progression Study

Posted on May 19, 2014

Peterson D, Munger C, Crowley J, Corcoran C, Cruchaga C, Goate AM, Norton MC, Green RC, Munger RG, Breitner JCS, Welsh-Bohmer KA, Lyketsos C, Tschanz J, Kauwe JSK; Alzheimer’s and Dementia 10(3) pp 366-371 Read More

Posted in: HPAN, Neurodegeneration, Neurogenetics, Publications Faculty: ,