Investigating the interface between nerve and muscle
Peripheral nerve pathology is devastating. In order to best understand the mechanisms of development, disease, and repair of the peripheral nervous system (PNS), all components of the PNS should be evaluated. Movement requires both neural input and muscle. My laboratory investigates the interface between nerve and muscle, the neuromuscular junction (NMJ). Specifically, we focus on terminal Schwann cells, which are the specialized glial cells located at the NMJ. Our lab investigates the roles of terminal Schwann cells during development, disease, neural regeneration and muscular reinnervation, and aging. The goals of our work are to identify the mechanisms of terminal Schwann cell function that may be manipulated into novel translational applications for clinical management of patients with peripheral nerve pathology.