Strategies for increasing progranulin levels as potential therapies for progranulin-deficient FTD
Our lab studies progranulin – a protein linked to frontotemporal dementia (FTD) – and how its deficiency causes neurodegeneration. We are currently testing strategies (including antisense oligonucleotides) for increasing progranulin levels as potential therapies for progranulin-deficient FTD. We are also investigating progranulin’s structure and function using a variety of molecular and cellular approaches. Our research program is very much aligned with the Hope Center’s mission to improve the lives of people living with neurological disorders, through collaborative research that aims to discover fundamental mechanisms of neurodegeneration and repair, and translate that new understanding into cures and treatments.