Anil Cashikar, PhD

Associate Professor, WashU Psychiatry

Oxysterols in Alzheimer’s disease

Oxysterols are hydroxylated cholesterols, which influence a wide variety of cellular pathways including endolysosomal trafficking, cholesterol biosynthesis and cell surface and nuclear receptor signaling among others. These intracellular effects manifest as major regulatory steps in lipid homeostasis, inflammatory signaling, neuromodulation and cell migration. We are interested in understanding how oxysterols influence neuroinflammation, synaptic dysfunction and neurodegeneration in Alzheimer’s disease.