Conrad (Chris) Weihl, MD, PhD

Conrad (Chris) Weihl, MD, PhD

Professor, WashU Neurology

Protein degradation pathways and their relation to aging, muscle weakness and neurodegeneration

My lab is particularly interested in the pathogenesis of inclusion body myopathy, paget’s disease of the bone and frontotemporal dementia or IBMPFD, a multisystem degenerative disorder due to missense mutations in p97/VCP/cdc48.  IBMPFD muscle and brain tissue contains ubiquitinated protein inclusions associated with cellular degeneration and vacuolation.

1) How IBMPFD mutations in VCP lead to these pathologic features and
2) what is the normal function of VCP in protein degradation pathways are the fundamental questions being addressed by our research.

More about the Weihl lab