David Gutmann, MD, PhD

David Gutmann, MD, PhD

Donald O. Schnuck Family Professor, WashU Neurology

Leveraging neurogenetic disorders to study normal brain development, cancer, and autism

Using the common neurogenetic condition, Neurofibromatosis type 1 (NF1) as a model system to understand growth and differentiation in the normal brain, the Gutmann laboratory aims to characterize the genomic, genetic, cellular, and molecular factors that contribute to the development of nervous system tumors (gliomas and neurofibromas), brain development abnormalities, and behavioral deficits.

Defining these contributing factors represents the first step toward establishing new treatments for children and adults with NF1. Moreover, NF1 provides unique opportunities to unravel the complexities of related medical problems in the general population, including adult and childhood brain tumors and autism.

Current research in our laboratory includes:

  1. Modeling human neurological disease using genetically-engineered mice and human induced pluripotent stem cells (precision medicine)
  2. Delineating how immune system-like cells (T cells and microglia) dictate brain tumor development and neuronal dysfunction (neuroimmunology)
  3. Determining the molecular and cellular mechanisms underlying neuronal control of nervous system tumor formation and growth (cancer neuroscience)
  4. Defining the role of stem cells in normal brain development and in pediatric brain tumors,
  5. Developing next generation models of pediatric brain tumors.

In our laboratory, we are firmly committed to mentoring trainees at all levels. We honor diversity of thought and identities, and strive to make our laboratory an inclusive and supportive team.

More about the Gutmann lab