Gabor Egervari, MD, PhD
Assistant Professor, WashU Genetics and Biochemistry and Molecular Biophysics
- Email: gabor@nospam.wustl.edu
Metabolic-epigenetic interactions in the healthy and diseased brain
My research program aims to understand how metabolic changes influence gene expression in the brain. Specifically, I investigate the recruitment of metabolic enzymes to the nucleus and to chromatin in different brain regions and different cell types. I am particularly interested in examining the role of these pathways during exposure to harmful stimuli, such as abused substances. Research in my laboratory will explore how metabolites of drugs affect epigenetic regulation in the brain, and how this contributes to transcriptional changes that underlie substance use disorders and developmental exposure to drugs. In addition, my lab will study the role of metabolic-epigenetic interactions in neurodegeneration, where epigenetic changes are quickly emerging as an important novel disease mechanism. By examining these fundamental biological processes, my research program will have the potential to uncover novel therapeutic targets for substance use disorders, fetal alcohol spectrum disorder and neurodegeneration.