Meeting Archives

Lysosome Processing & Transport Group

2023/2024 Schedule

Organizer: Celeste Karch

  • October 19, 2023: Farzané Mirfakhar (Karch lab, WashU Psychiatry) “Cellular Cleanup Gone Awry: Lysosomal dysfunction in stem cell models of frontotemporal dementia”
  • November 16, 2023: Rachel Kinsella (Stallings lab, WashU Molecular Microbiology) “ATG5 suppresses type I interferon-dependent neutrophil effector responses to control Mycobacterium tuberculosis”
  • January 18, 2024: Sandra Encalada (The Scripps Research Institute) “Activation of Neuronal Degradative Pathways to Ameliorate Prion Disease”
  • February 15, 2024: Keigo Takahashi (Cooper lab, WashU Pediatrics) “Defining the contribution of GABAergic interneuron deficits to epileptogenesis in neurodegenerative lysosomal storage disorders”
  • March 21, 2024: Yan Xiong (Sardiello lab, WashU Pediatrics) “TFEB degradation is regulated by an IKK/β-TrCP2 phosphorylation-ubiquitination cascade”
  • April 18, 2024: Hui Ye (Baylor College of Medicine) “An Evolutionarily Conserved Role of Retromer in Orchestrating Traffic between Synapses and Lysosomes”
  • May 16, 2024: Michio Inoue (Weihl lab, WashU Neurology) “Conditional Knockout Mouse for the Assembly Factor of the Vacuolar ATPase VMA21 Models Myopathy and Dysfunctional Autophagy”
2022/2023 Schedule

Organizer: Celeste Karch

  • September 15, 2022: Marco Colonna (WashU Pathology & Immunology)
  • VIRTUAL October 20, 2022: Maria Catarina Silva (Harvard University) “Chemical Biology Strategies for Rescue of Tauopathy in Human Neurons”
  • VIRTUAL November 17, 2022: Sandra Maday (University of Pennsylvania) “Autophagy-lysosomal pathways in neurons and astrocytes”
  • December 15, 2022: Shoutang Wang (Colonna lab, WashU Pathology & Immunology) “Microglia as target for immunotherapy for Alzheimer’s disease”
  • VIRTUAL January 19, 2023: Aimee Kao (University of California, San Francisco) “Aging, Lysosomes and Neurodegenerative Disease”
  • HYBRID February 16, 2023: Seongwon Lee (Yoo lab, WashU Developmental Biology) “Longitudinal modeling of human neuronal aging: Identification of RCAN1-TFEB pathway contributing to the degeneration of Huntington’s disease via autophagy reduction”
  • VIRTUAL March 16, 2023: Rebecca Wallings (University of Florida) “Totally tubular: Modulation of the immune response by LRRK2 via lysosomal tubulation; an avenue for potential novel PD-therapeutics”
  • HYBRID April 20, 2023: Adelita Mendoza (Kornfeld lab, WashU Developmental Biology) “Lysosomes contain an expansion compartment that mediates zinc transporter delivery to promote zinc homeostasis in C. elegans”
  • HYBRID May 18, 2023: Jennifer Portillo (Davis lab, WashU Neurology) “The role of PPT1 haploinsufficiency is Parkinson’s disease”
2021/2022 Schedule

Organizers: Bruno Benitez, Carlos Cruchaga, Celeste Karch

  • August 19, 2021: Mark Cookson (National Institute on Aging/NIH) “Lysosomal activation of Leucine-Rich Repeat Kinase 2 in the molecular pathogenesis of Parkinson’s disease”
  • September 16, 2021: Allen Seylani (National Heart, Lung, and Blood Institute/NIH) “Novel Regulatory Function of GCN5L1 In Lysosomal Biology – A potential Therapeutic Target In Neurodegenerative Diseases”
  • October 21, 2021: Peter Lobel (Rutgers University) “From basic research on lysosomal targeting to disease discovery and drug development”
  • November 18, 2021: Joshua Shulman (Baylor College of Medicine) “Functional Genomics of the Lysosome in Parkinson’s Disease”
  • Postponed – December 16, 2021: Michael Ward (NINDS/NIH) “Proteins on tap – Lysosomal regulation of axonal RNA transport and local translation”
  • January 20, 2022: Andy Nguyen (Saint Louis University) “ASO-based therapeutic approach for progranulin-deficient frontotemporal dementia”
  • February 17, 2022: Emily Mangano Rocha (University of Pittsburgh) “Characterizing the link between LRRK2 and lysosomal dysfunction in Parkinson’s disease” 
  • March 17, 2022: Adamantios Mamais (University of Florida) “Dysregulation of iron homeostasis downstream of LRRK2 signaling”
  • April 21, 2022: Malú Gámez Tansey (University of Florida) “LRRK’ing around at the lysosome: Assessing the effects of LRRK2 and other PD-risk genes on lysosomal function in peripheral immune cells”
  • CANCELLED – May 19
  • CANCELLED – June 16, 2022: Michael Ward (NINDS/NIH) “Proteins on tap – Lysosomal regulation of axonal RNA transport and local translation”
2020/2021 Schedule

Organizers: Bruno Benitez and Carlos Cruchaga

  • August 20, 2020: Cliff Luke (WashU Pediatrics) “Lysoptosis: an ancient and evolutionarily-conserved cell death pathway moderated by intracellular Serpins”
  • October 15, 2020: Michael Flanagan (Montaño lab, Saint Louis University) “Role of Miglustat in a Hypophosphatasia Mouse Model”
  • December 17, 2020: Hemanth Ramesh Nelvagal (Cooper lab, WashU Pediatrics) “Early CNS manifestations of CLN1 disease”
  • February 18, 2021: Michelle Hastings (Rosalind Franklin University of Medicine and Science) “Antisense oligonucleotides for the treatment of CLN3 Batten disease”
  • April 15, 2021: Dimitri Krainc (Northwestern University) “The Interplay of Mitochondrial and Lysosomal Dysfunction in Parkinson’s Disease”
  • May 20, 2021: Peter Lansbury (Bial Biotechnology, Harvard University) “Discovery and development of a glucocerebrosidase activator for GBA-Parkinson’s Disease”
2019/2020 Schedule

Organizers: Bruno Benitez and Carlos Cruchaga

  • August 15, 2019: Sidhartha Mahali (Karch lab, WashU Psychiatry) “Lysosomal defect in stem cell models of neurodegeneration”
  • October 17, 2019: Mike Flanagan (Montaño lab, Saint Louis University) “Development of hydrogels for sustained release of GALNS enzyme”
  • December 19, 2019: Jonathan Cooper (WashU Pediatrics) “The same, but different: new insights into NCL pathogenesis”
  • February 20, 2020: Yedda Li (Sands lab, WashU Medicine) “Pathophysiology and Treatment of Murine Globoid Cell Leukodystrophy”
  • CANCELLED – April 16, 2020: Adelita Mendoza (Kornfeld lab, WashU Developmental Biology)