Tag: Rohit Pappu

Research from labs of Rohit Pappu, collaborators sheds light on condensate characteristics

Symposium brings together key leaders in the field

Research uncovers how unfolded proteins are discarded, and how a perfectly good protein can wind up in the trash

Every cell contains millions of protein molecules. Some of them have the ability to phase-separate to form non-membrane-bound compartments, called biomolecular condensates, inside a cell. It has long been assumed that there was no further structure underlying these condensates, only solution-soluble proteins. A research group led by Rohit Pappu, PhD, the Gene K. Beare Distinguished Professor […]

Intrinsically disordered regions (IDRs) of proteins, when tethered to folded domains, function either as flexible tails or as linkers between domains. Most IDRs are composed of a mixture of oppositely charged residues. Recent measurements of tethered polyampholytes have shown that arginine- and lysine-rich sequences tend to behave very differently from one another. In a paper […]

These vesicles are critical for proper cell function