Research from labs of Rohit Pappu, collaborators sheds light on condensate characteristics
Interfaces play important role in condensate behavior

Research from labs of Rohit Pappu, collaborators sheds light on condensate characteristics
Symposium brings together key leaders in the field
Research uncovers how unfolded proteins are discarded, and how a perfectly good protein can wind up in the trash
Scopus list of publications for September 4, 2022
Every cell contains millions of protein molecules. Some of them have the ability to phase-separate to form non-membrane-bound compartments, called biomolecular condensates, inside a cell. It has long been assumed that there was no further structure underlying these condensates, only solution-soluble proteins. A research group led by Rohit Pappu, PhD, the Gene K. Beare Distinguished Professor […]
Intrinsically disordered regions (IDRs) of proteins, when tethered to folded domains, function either as flexible tails or as linkers between domains. Most IDRs are composed of a mixture of oppositely charged residues. Recent measurements of tethered polyampholytes have shown that arginine- and lysine-rich sequences tend to behave very differently from one another. In a paper […]
Longstanding collaboration leads to new findings about processes associated with neurodegenerative diseases
These vesicles are critical for proper cell function
List of publications for the week of November 8, 2021
NIH awards $3.1 million grant for Washington University, St. Jude ALS research