Annual Hope Center Retreat

The Annual Hope Center Retreat will be held at the Danforth Plant Science Center.

13th Annual Hope Center Retreat

Tuesday, April 23, 2024

All day event | Donald Danforth Plant Science Center

Hope Center Lecture

Joseph Lewcock, PhD

Chief Scientific Officer and Head of Discovery
Denali Therapeutics

“Targeting brain delivery of biotherapeutics for neurodegenerative disease“

Congratulations to the winners
of the Hope Center Awards!

Recognizing trainees’ exceptional research and presentations at the Annual Hope Center Retreat

Join us for a Special Hope Center/Neurology Seminar
on June 3rd at 12p for presentations by Vishnu, Julie and Yuxiao.
The seminar will be held in the Fort NRB Auditorium and via Zoom.

For inquiries contact the Hope Center at hopecenter@email.wustl.edu.

Short talks

Vishnu Muraleedharan Saraswathy, PhD

Postdoctoral researcher
in the lab of Mayssa Mokalled

“Single-cell analysis of innate spinal cord regeneration identifies intersecting modes of neuronal repair”

Poster Presentations

Julie Choi

Graduate student
in the labs of Jeffrey Milbrandt and Peter Jin

“Single-Cell Sciatic Nerve Atlas Unveils Il-1β+ Macrophages and T Cells as Drivers of Neurodegeneration in a SARMopathy Mouse Model”

Yuxiao Xu

Graduate student
in the lab of Mayssa Mokalled

“Mapping regenerative stem cells during innate spinal cord repair”

  • Welcome and Opening Remarks – David Holtzman (Hope Center Scientific Director) and Anneliese Schaefer (Hope Center Executive Director)
  • Welcome from Retreat Organizers – Geraldine Kress (WashU Neurology) and Brian Gordon (WashU Radiology)
  • Short talks Session I – Moderated by Jason Ulrich (WashU Neurology)
    • Eileen Lynch (Weihl lab, WashU Neurology) – “TDP-43 aggregation and seeding in skeletal muscle”
    • Karl Friedrichsen (Brier lab, WashU Neurology) – “Increased S1PR1 Expression in Multiple Sclerosis Lesions Compared to Normal-Appearing White Matter as Measured by 11C-CS1P1 PET”
    • Yun Chen (Holtzman and Colonna labs, WashU Neurology and Pathology & Immunology) – “APOE3ch alters microglial response and suppresses Ab-induced tau seeding and spread”
    • Masatoshi Inoue (WashU Radiology) – “Multimodal Optical Interrogation of Neural Circuits that Control Social Interactions”
  • Danny Jaschek (WashU Medicine Corporate & Foundation Relations) –
    Speaker Introduction – Anneliese Schaefer (WashU Neurology)
  • Short talks Session II – Moderated by Aisling Chaney (WashU Radiology)
    • Vishnu Muraleedharan Saraswathy (Mokalled lab, WashU Developmental Biology) – “Single-cell analysis of innate spinal cord regeneration identifies intersecting modes of neuronal repair”
    • Zelun Wang (Williams and Apte labs, WashU Ophthalmology & Visual Sciences) – “Energetic heterogeneity in retinal ganglion cells: role of neuronal activity and implications for resilience”
    • Marta Celorrio (Friess lab, WashU Pediatrics) – “Gut Microbiota shape oligodendrocyte response after TBI”
  • Hope Center Lecture
    Speaker Introducation – David Holtzman (WashU Neurology)
    • Joseph Lewcock (Denali Therapeutics) – “Targeting brain delivery of biotherapeutics for neurodegenerative disease”
  • Short talks Session III – Moderated by Carla Yuede (WashU Psychiatry)
    • Farzaneh Mirfakhar (Karch lab, WashU Psychiatry) – “Trapped in transit: Tau accumulates in stem cell model of tauopathy through Autophagy and lysosomal impairments”
  • Short talks Session IV – Moderated by Miguel Minaya (WashU Psychiatry)
    • Joseph Bradley (Cruchaga lab, WashU Psychiatry) – “Novel genes and risk loci identified in large-scale multi-ethnic analysis of earlier-onset Alzheimer Disease”
    • Caitlin Dingwall (Milbrandt lab, WashU Genetics) – “Phosphatidylserine exposure is an early SARM1-dependent axonal danger signal that triggers phagocytosis of stressed-but-viable axons”
    • Aleksandra Beric (Ibanez lab, WashU Psychiatry) – “Circulating blood circular RNA in Parkinson’s Disease; a systematic study”
    • Yang Li (WashU Genetics and Neurosurgery) – “A comparative atlas of single-cell chromatin accessibility in the human brain”
  • Closing Remarks
  • Poster Session
View printable program
View poster program (WUSTL key required)

About

The Hope Center Annual Retreat provides an opportunity to go off-site for a day, focus on Hope Center research, and learn more about transnational Neuroscience outside Washington University. Hope Center faculty and members of their laboratories learn about the latest findings and future directions of member labs in the context of short talks and a poster session. Keynote lectures feature invited speakers who lead their fields with a research/clinical program aligned with the Hope Center mission.

Stay tuned for details below and also on the Office of Neuroscience Research (ONR) Calendar.

For questions about the Hope Center Retreat contact the Hope Center.

Hope Center Awards

Recognizing an exceptional presentation by a trainee at the Annual Hope Center Retreat.

Hope Center Lecture

The keynote Hope Center Lecture is presented at the Annual Hope Center Retreat.