View the retreat programs from years past.

2023 Retreat: April 18, Danforth Plant Science Center

Welcome and Opening Remarks – David Holtzman and Anneliese Schaefer (WashU Neurology)

Welcome from Retreat Organizers – Geraldine Kress (WashU Neurology) and Brian Gordon (WashU Radiology)

Short talks Session I – Moderated by Jason Ulrich (WashU Neurology)

  • Sheng (Andy) Chen (Jackrel lab, WashU Chemistry) – “HtrA1 prevents and reverses α-synuclein aggregation, rendering it non-toxic and seeding incompetent”
  • Megan Bosch (Holtzman lab, WashU Neurology) – “Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a dose- and sex-specific manner”
  • Aisling Chaney (WashU Radiology) – “Non-invasive PET imaging of neuroimmune responses in Neurodegeneration”

Short talks Session II – Moderated by Oscar Harari (WashU Psychiatry)

  • Daniel Western (Cruchaga lab, WashU Psychiatry) – “Integration of cerebrospinal fluid pQTL and GWAS prioritizes novel candidate genes involved in Alzheimer’s disease”
  • Reshma Bhagat (Karch lab, WashU Psychiatry) – “Long non-coding RNA SNHG8 drives stress granule formation in MAPT mutation carriers”
  • Chengcheng Li (Weihl lab, WashU Neurology) – “Comprehensive functional characterization of SGCB variants causing Limb-Girdle Muscular Dystrophy”

Hope Center Lecture
Speaker Introduction by David Holtzman (WashU Neurology)

  • Michael Ward (NINDS, NIH) – “Leveraging iPSC models and ‘omics to unlock the mysteries of neurodegenerative diseases”

Short talks Session III – Moderated by Aaron DiAntonio (WashU Developmental Biology)

  • Rui (Rikki) Feng (Cavalli lab, WashU Neuroscience) – “Antagonizing Endothelin B receptor in satellite glial cells improves nerve regeneration and aging-dependent neuronal regenerative decline”
  • Ikbal Şencan-Eğilmez (WashU Radiology) – “Optical microscopy for quantifying oxygenation and blood flow during healthy and diseased conditions in mouse: Brain and beyond”

Short talks Session IV – Moderated by Celeste Karch (WashU Psychiatry)

  • Bridget Phillips (Cruchaga lab, WashU Psychiatry) – “Proteome Wide Association Studies of LRRK2 variants identify novel causal and druggable proteins for Parkinson’s disease”
  • Danira Toral Rios (Cashikar/Paul lab, WashU Psyhiatry) – “25-hydroxycholesterol mediates neuroinflammation and neurodegeneration in a tauopathy mouse model”

Closing Remarks

Poster Session

2022 Retreat: May 10, Hybrid
Zoom: Short talks, keynote lectures; In person: Poster session

Welcome and Opening Remarks – David Holtzman, MD and Anneliese Schaefer, JD, PhD

Welcome from Retreat Organizers – Celeste Karch, PhD and Carlos Cruchaga, PhD

Session 1: Neurogenetics & Transcriptomics
Moderated by Gabriel Haller, PhD (Neurosurgery)

  • Jiayang Chen (Dougherty Lab, Genetics)
    “Molecular functions of ID/ASD-associated MYT1L during early brain development”
  • Ciyang Wang (Cruchaga Lab, Psychiatry)
    “Discovery of genetic regulators of human metabolites in CSF”

Session 2: Clocks & Sleep Club and Lysosome Processing & Transport
Moderated by Paul Taghert, PhD (Neuroscience)

  • Samira Parhizkar, PhD (Holtzman Lab, Neurology)
    “Sleep loss exaggerates TREM2-dependent inflammation irrespective of amyloid plaque deposition”
  • Celia McKee (Musiek Lab, Neurology)
    “The astrocyte circadian clock regulates autophagy and endolysosome function”

Hope Center Lecture
Speaker Introduction by Conrad Weihl, MD, PhD (Neurology)

  • Louise Rodino-Klapac, PhD (Sarepta Therapeutics, Inc.)
    “Development of gene therapies for muscular dystrophies”

Hope Center Lecture
Speaker Introduction by Celeste Karch, PhD (Psychiatry)

  • Martin Kampmann, PhD (University of California, San Francisco)
    “Elucidating molecular and cellular mechanisms of neurodegenerative disease by CRISPR-based functional genomics”

Session 3: Protein Aggregation & Neurodegeneration and Lipid Metabolism
Moderation by Anil Cashikar, PhD (Psychiatry)

  • Shih Feng You (Karch Lab, Psychiatry)
    “MS4A4A modifies the risk of Alzheimer’s disease and regulates cholesterol metabolism and immune response”
  • Antoine Drieu, PhD (Kipnis Lab, Pathology & Immunology)
    “Parenchymal border macrophages regulate brain physiology via CSF flow dynamics”

Neurovascular Injury & RepairAxon Injury & Repair, and NeuroRestorative Therapy 
Moderated by Valeria Cavalli, PhD (Neuroscience)

  • Xiaodan Wang (Bauer Lab, Radiology)
    “Dual fluorophore imaging along the neurovascular coupling pathway”
  • Dana Shaw, PhD (Mokalled lab, Developmental Biology)
    “An intricate immune balance necessary for natural spinal cord regeneration”

Poster Session

2021 Retreat: May 11, Zoom conference

Welcome and Opening Remarks – David Holtzman, MD and Anneliese Schaefer, JD, PhD

NeuroRestorative Therapy Group
NeuroRestorative Session Chair: Hiroko Yano, PhD (WashU Neurosurgery)

  • Lu Zhao, PhD (Cui Lab, WashU Biomedical Engineering)
    “A potential sonogenetic actuator for ultrasound-mediated neuromodulation”

Neurogenetics & Transcriptomics Group
Neurogenetics Session Chair: Gabriel Haller, PhD (WashU Neurosurgery)

  • Logan Brase (Harari Lab, WashU Psychiatry)
    “Single-nuclei RNA-sequencing of Alzheimer Disease brains reveals altered cell expression state compositions linked to autosomal dominant, TREM2 and rs1582763 variants”
  • Chengran Yang (Cruchaga Lab, WashU Psychiatry)
    “Genomic and multi-tissue proteomic integration for understanding the genetic architecture of Alzheimer disease and Parkinson’s disease”

Protein Aggregation & Neurodegeneration Group
Neurodegeneration Session Chair: Chris Weihl, MD, PhD ( WashU Neurology)

  • Jiang Zhu (Weihl Lab, WashU Neurology)
    “VCP protects neurons from proteopathic seeding”
  • Maud Gratuze, PhD (Holtzman Lab, WashU Neurology)
    “Activated microglia mitigate Aβ-associated tau seeding and spreading”
  • Lucia Capano (Yoo Lab, WashU Developmental Biology)
    “MicroRNA-mediated neuronal reprogramming generates human neurons that express tau isoform expression comparable to adult brains”
  • Zachary Grese (Ayala Lab, SLU Biochemistry Molecular Biology)
    “RNA is a platform for TDP-43 liquid-liquid phase separation and promotes TDP-43 solubility through specific binding”

Clocks & Sleep Club
Clocks & Sleep Session Chair: Erik Herzog, PhD (WashU Biology)

  • Patrick Sheehan (Musiek Lab, WashU Neurology)
    “Astrocytic BMAL1 regulates protein aggregation in mouse models of alpha-synuclein and tau pathology”

Hope Center Lecture
Speaker Introduction: Timothy Miller, MD, PhD (WashU Neurology)

  • Merit Cudkowicz, MD, MSc (Harvard Medical School, Massachusetts General Hospital)
    “New Therapies for ALS”

2020 Retreat: Cancelled due to the COVID-19 pandemic
2019 Retreat: April 16, Danforth Plant Science Center


Welcome and Opening Remarks – David Holtzman, MD and Anneliese Schaefer, JD, PhD

Session 1: Lysosome Processing & Transport Group
Lysosome Chair: Bruno Benitez, MD (Psychiatry)

  • Leah Czerniewski (Lee Lab, Neurology)
    “Tracking the intracellular itinerary of APP and de novo Aβ generation using click chemistry”
  • Andrew Findlay, MD (Weihl Lab, Neurology)
    “Lithium chloride corrects weakness and myopathology in a preclinical model of LGMD1D”

Session 2: Protein Aggregation & Neurodegeneration Group
Neurodegeneration ChairTimothy Miller, MD, PhD (Neurology)

  • Fabia Filipello, PhD (Piccio Lab, Neurology/Karch Lab, Psychiatry)
    “The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer disease risk”
  • Rachel French, PhD (Ayala Lab, SLU Biochemistry)
    “TDP-43 oligomers detected as initial intermediate species during aggregate formation“

Session 3: Neurogenetics & Transcriptomics Group
Neurogenetics Chair: Oscar Harari, PhD (Psychiatry)

  • Matthew Lalli, PhD (Mitra/Milbrandt Labs, Genetics)
    “Rapid high-throughput single-cell neurodevelopmental disease modeling”
  • Michael Vasek, PhD (Dougherty Lab, Genetics)
    “Microglia: Local translation and synaptic homeostasis”

Hope Center Lecture – Guoping Feng, PhD (Massachusetts Institute of Technology)
“Dissecting synaptic and circuitry mechanisms of psychiatric disorders”

Hope Center Lecture – Sally Temple, PhD (Neural Stem Cell Institute)
”Neural stem cells in aging and modeling neurodegenerative disease”

Session 4:  Clocks & Sleep Club and NeuroRestorative Therapy Group
Clocks & Sleep ChairYao Chen, PhD (Neuroscience)
NeuroRestorative ChairFumihiko Urano, MD, PhD (Medicine)

  • Percy Griffin (Musiek Lab, Neurology)
    Circadian regulation of neuroinflammation and neurodegeneration by Rev-erbα
  • Sindhu Manivasagam (Klein Lab, Medicine)
    “Investigating type III interferons as a novel therapeutic target during autoimmune neuroinflammation”

Session 5:   Neurovascular Injury & Repair and Axon Injury & Repair Groups
Neurovascular Chair: Jin Moo Lee, MD, PhD (Neurology)
Axon Chair: Valeria Cavalli, PhD  (Neuroscience)

  • Hailun Li (DiAntonio Lab, Developmental Biology)
    “A novel potassium buffering mechanism for neuroprotection against ischemic stroke
  • Satya Kothapalli, PhD (Yablonskiy Lab, Radiology)
    “In vivo measurements of Alzheimer disease-related neuronal loss in the hippocampal subfields with quantitative Gradient Recalled Echo (qGRE) MRI”

Poster session

2018 Retreat: April 10, Danforth Plant Science Center


Welcome and Opening Remarks from David Holtzman, MD and Anneliese Schaefer, JD, PhD

Hope Center Lecture – Leonard Petrucelli, PhD (Mayo Clinic Florida) 

“Mechanistic and Therapeutic Insights into c9FTD/ALS”

Session 1: Neurodegeneration Group (Chair: Timothy Miller, MD, PhD (Neurology))

  • Kiersten Ruff, PhD (Pappu Lab, Biomedical Engineering)
    “Polyglutamine length dependent structural properties and phase behavior of huntingtin exon 1”
  • Tien-Phat Huynh (Holtzman Lab, Neurology)
    “Age-dependent effects of apoE reduction using antisense oligonucleotides in a model of β-amyloidosis”

Session 2: Lysosome Processing & Transport Group (Chair: Bruno Benitez, MD (Medicine)); NeuroRestorative Therapy Group (Chairs: Albert Kim, MD, PhD (Neurosurgery) and Fumihiko Urano, MD, PhD (Medicine))

  • Devi Annamalai, PhD (Kim Lab, Neurosurgery)
    “Epigenomic reprogramming as a therapeutic strategy for malignant gliomas”
  • Sidhartha Mahali, PhD (Karch Lab, Psychiatry)
    “Lysosomal dysfunction and altered tau metabolism in stem cell models of autosomal dominant Alzheimer’s disease”

Session 3: Neurovascular Injury & Repair Group (Chair: Jin-Moo Lee, MD, PhD (Neurology))

  • Charise Garber (Klein Lab, Medicine)
    “T-cells promote microglial activation and prevent cognitive recovery from viral encephalitis via interferon gamma”
  • Deepti Diwan, PhD (Zipfel Lab, Neurosurgery)
    “Sirt1 mediates hypoxic conditioning-induced delayed cerebral ischemia protection in subarachnoid hemorrhage”

Session 4: Neurogenetics & Transcriptomics Group (Chair: Carlos Cruchaga, PhD (Psychiatry))

  • Umber Dube (Cruchaga Lab, Psychiatry)
    “Circular RNAs in Alzheimers disease brain tissues”
  • Denis Avey, PhD (Milbrandt Lab, Genetics)
    “Single cell RNA-seq facilitates characterization of glial and neuronal responses to morphine”

Session 5: Axon Injury & Repair Group (Chair: Valeria Cavalli, PhD (Neuroscience))

  • Scott Karney-Grobe (DiAntonio Lab, Developmental Biology)
    “HSP90 is a chaperone for DLK and is required for axon injury signaling”
  • Deng Pan (Mackinnon Lab, Surgery)
    “Reduced T cell accumulation in long gap nerve injuries inhibit peripheral nerve regeneration”

Poster session

2017 Retreat: May 9, Danforth Plant Science Center


Welcome and Opening Remarks from David Holtzman, MD and Anneliese Schaefer, JD, PhD

Session 1: Neurogenetics & Transcriptomics (Chair: Carlos Cruchaga, PhD (Psychiatry))

  • Kristina Sakers (Dougherty Lab, Genetics)
    “Astrocyte local translation and the role of quaking RNA binding protein in mRNA export and protein stability”
  • Victoria Fernandez, PhD (Cruchaga Lab, Psychiatry)
    “Novel candidate variants in late onset Alzheimer Disease detected by the Familial Alzheimer Sequencing (FASe) Project”

Session 2: Neurovascular Injury & Repair (Chair: Jin-Moo Lee, MD, PhD (Neurology))

  • Hamid Salimi, PhD (Klein Lab, Neuroscience)
    “Encephalitic alphaviruses: neurotropism and mechanisms of CNS entry”
  • Zachary Rosenthal (Lee Lab, Neurology)
    “Recovery of cortical delta band functional connectivity after focal ischemia”

Session 3: Axon Injury & Repair (Chair: Valeria Cavalli, PhD (Neuroscience))

  • Kow Essuman (Milbrandt Lab, Genetics)
    “Identification of the NAD+ consuming enzyme that promotes axonal death during injury and disease”
  • Young Mi Oh, PhD (Cavalli Lab, Neuroscience)
    “miRNA-9 regulates axon regeneration through modulation of the epigenetic factor UHRF1 and the transcriptional regulator REST”

Roderick Corriveau, PhD (NIH/NINDS)

“NINDS Mission, AD/ADRD Research Initiatives, Training and Diversity Career Development”

Hope Center Lecture:  Laura Ranum, PhD (University of Florida)

“Repeat associated non-ATG (RAN) translation: new starts and directions in neurologic disease”

Session 4: Neurodegeneration (Chair: Timothy Miller, MD PhD (Neurology))

  • Yang Shi, PhD (Holtzman Lab, Neurology)
    “Effect of apolipoproteinE on tau pathogenesis and tau-mediated neurodegeneration”
  • Min-Yu Sun, PhD (Mennerick Lab, Psychiatry)
    “A chemogenetic approach reveals synaptic contributions of δ subunit-containing GABAA receptors in dentate granule neurons”

Session 5: Lysosome Processing & Transport and NeuroRestorative Therapy (Chairs: Bruno Benitez, MD and Fumihiko Urano, MD PhD (Medicine))

  • Yedda Li (Mark Sands, Genetics)
    “Combination therapy increase lifespan and improves clinicobehavioral performance in the murine model of globoid cell leukodystrophy”
  • Daniel Abernathy (Andrew Yoo, Developmental Biology)
    “MicroRNA-induced epigenetic remodeling during direct cell-fate conversion of adult human fibroblasts”

Poster session

2016 Retreat: May 3, Danforth Plant Science Center


Welcome and Opening Remarks from David Holtzman, MD and Anneliese Schaefer, JD, PhD

Session 1: Axon Injury & Repair (Chairs: Valeria Cavalli, PhD(Neuroscience) / David Brody, MD, PhD (Neurology))

  • Dan Carlin, PhD (Cavalli Lab, Neuroscience)
    “mTOR activation stimulates axon regeneration in nociceptive neurons without promoting pain” 
  • Lauren Walker (DiAntonio Lab, Developmental Biology)
    “MAPK signaling functions upstream of SARM1 to promote axonal degeneration”

Session 2:  Neurogenetics (Chair: Christina Gurnett, MD, PhD(Neurology))

  • Darshan Sapkota, PhD  (Dougherty Lab, Genetics)
    “Cell type-specific translational profiling of the mouse brain by coupling TRAP to ribosome footprinting”
  • Yuetiva Robles (Cruchaga Lab, Psychiatry)
    “CSF levels of amyloid beta and tau as endophenotypes reveal novel variants potentially informative for Alzheimer disease”

Session 3:  Clocks/Neurovascular (Chair/s: Dmitri Nusinow, PhD (Danforth Plant Science Center) /Andria Ford, MD and Jin-Moo Lee, MD, PhD (Neurology))

  • Brian Lananna (Musiek Lab, Neurology)
    “The astrocyte circadian clock regulates astrogliosis and neuronal injury”
  • Courtney Sobieski (Mennerick Lab, Psychiatry)
    “Reductionism reveals resilience: meeting neuronal energetic demands in a stark environment”

Orla Smith, PhD (Managing Editor, Science Translational Medicine)

“Challenges in scientific publishing: an editor’s perspective”

Hope Center Lecture: Beverly Davidson, PhD (University of Pennsylvania)

“Emerging therapies for inherited brain diseases”

Session 4:  Neurodegeneration (Chair:  Chris Weihl, MD, PhD(Neurology))

  • Tyler Ulland, PhD (Colonna Lab, Pathology and Immunobiology)
    “TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques” 
  • Christina Ising, PhD (Holtzman Lab, Neurology)
    “AAV-mediated expression of anti-tau scFvs markedly decreases pathological tau accumulation in a mouse model of tauopathy”
  • Dhruva Dhavale, PhD (Kotzbauer Lab, Neurology)
    “Structural requirements of alpha-synuclein fibril formation” 
  • Mariah Lawler (Miller Lab, Neurology)
    “Cell type specific miRNA profiling reveals candidate biomarker of motor neuron disease”

Poster session

2015 Retreat: May 5, Danforth Plant Science Center


Welcome and Opening Remarks Celeste Karch & Carlos Cruchaga

Session 1: Neurovascular Injury & Repair (Chair: Andria Ford (Neurology))

  • Andrew Kraft (Lee Lab, Neurology)
    “Sensory deprivation following cortical focal ischemia facilitates  remapping and accelerates behavioral recovery”
  • Rafael Galindo (Assistant Professor, Neurology)
    “Neuroprotective role of nicotinamide mononucleotide adenylyl-transferase 3 in a mouse model of neonatal cerebral ischemia”

Session 2: Axon Injury & Repair (Chair: David Brody (Neurology))

  • Yongcheol Cho (Cavalli Lab, Anatomy & Neurobiology)
    “Activating injury-responsive genes with hypoxia enhances axon  regeneration through neuronal HIF-1α”
  • Gwen Hoben (Mackinnon Lab, Surgery)
    “Characterization of senescent Schwann cells’ role in limiting axonal regeneration”

Session 3: Neurogenetics (Chair: Christina Gurnett (Neurology))

  • Sarah Petersen (Monk Lab, Developmental Biology)
    “GPR126 has distinct, domain-dependent functions in Schwann cell development mediated by interaction with laminin-211”
  • Gabriel Haller (Gurnett Lab, Neurology)
    “Massively parallel single nucleotide mutagenesis using reversibly- terminated inosine”

Hope Center Lecture: Daria Mochly-Rosen (Stanford University)
”Correcting Abnormal Mitochondrial Dynamics in Neurogenerative and Cardiovascular Diseases”

Session 4: New Research Interest Groups (Chair: Carlos Cruchaga (Psychiatry))

  • Lysosome Processing & Transport: Bruno Benitez (Sands Lab, Medicine)
    “Lysosomal and synaptic dysfunction in Autosomal Dominant Adult Onset Neuronal Ceroid Lipofuscinosis (AD-ANCL)”
  • Clocks & Sleep: Jerrah Holth (Holtzman Lab, Neurology)
    “The interaction between sleep and tau pathology in the P301S tauopathy mouse model”

Rajesh Ranganathan (NINDS/NIH)
“NINDS Office of Translational Research: New Programs to Support Therapy and Device Discovery and Development”

Session 5: Neurodegeneration (Chair: Chris Weihl (Neurology))

  • Chandana Buddhala (Kotzbauer Lab, Neurology)
    “Regional deficits in dopaminergic, serotonergic and noradrenergic innervation in Parkinson disease dementia”
  • Matthew Brier (Ances Lab, Neurology)
    “Local and distributed effect of amyloid deposition on glucose metabolism in preclinical Alzheimer’s disease”

Poster Session

2014 Retreat: April 15, Danforth Plant Science Center


Welcome and Opening Remarks Celeste Karch & Carlos Cruchaga

State of the Hope Center Alison Goate, Director

Session 1: Axon Injury & Repair (Chair: Valeria Cavalli (Anatomy and Neurobiology))

  • Matthew MacEwan (Ray Lab, Neurological Surgery)
    “Neuroregenerative electrodes enable functional electrical stimulation of peripheral motor axons and distal musculature”
  • Geraldine Kress (Mennerick Lab, Psychiatry)
    “Temporally distinct monosynaptic and disynaptic components of dopamine release”
  • Vera Valakh (DiAntonio Lab, Developmental Biology)
    “Cytoskeletal destabilization activates the DLK pathway to regulate synapse development and axonal regrowth”

Session 2: Neurovascular Injury & Repair (Chair: Jin-Moo Lee (Neurology))

  • Kathrin Andrich (Bieschke Lab, Biomedical Engineering)
    “Aggregation in Systemic light chain amyloidosis (AL amyloidosis)”
  • Eric Milner (Zipfel Lab, Neurological Surgery)
    “Post-conditioning reduces subarachnoid hemorrhage–inducedneurovascular dysfunction via HIF-1”
  • Andrei Vlassenko (Radiology)
    “Aerobic glycolysis in brain tumors”

Hope Center Lecture: Alfred W. Sandrock Jr (Biogen Idec)
”Innovation in Multiple Sclerosis: Past and Present ”

Session 3: Neurodegeneration (Chair: Chris Weihl (Neurology))

  • Matheus Victor (Yoo Lab, Developmental Biology)
    “Guided conversion of human fibroblasts to striatal neurons”
  • Kristen Funk (Diamond Lab, Neurology)
    “Modulation of pathogenic tau fibrils into microglia by antibodiesand heparin mimetics”
  • Shannon Macauley-Rambach (Holtzman Lab, Neurology)
    “Investigating the mechanistic link between diabetes and Alzheimer’sdisease: the effects of hyperglycemia on neuronal activity andAmyloid beta levels within the brain’s interstitial fluid”
  • Claudia Cantoni (Piccio Lab, Neurology)
    “Role of miR-223 in multiple sclerosis and its animal model”

Session 4: Neurogenetics (Chair: Matt Harms (Neurology))

  • Sarah DeGenova (Monk Lab, Developmental Biology)
    “The adhesion-GPCR Gpr56 regulates glial cell development andmyelination”
  • Maria Praggastis (Ory Lab, Medicine)
    “A murine Niemann-Pick C1 (NPC1) I1061T knockin modelrecapitulates the pathological features of the most prevalent humandisease allele”
  • Janet Cady (Harms Lab, Neurology)
    “TREM2 variant p.R47H as a risk factor for sporadic amyotrophiclateral sclerosis”

Poster session

2013 Retreat: April 23, Danforth Plant Science Center


Welcome and Opening Remarks: Anneliese Schaefer (Executive Director)

State of the Hope Center: Alison Goate (Director)

Session 1: Axon Injury & Repair (Chair: Aaron DiAntonio (Developmental Biology))

  • Elisabetta Babetto (DiAntonio Lab, Developmental Biology)
    “The Phr1 ubiquitin ligase promotes injury-induced axon self-destruction”
  • Jacqueline Hawkins-Salsbury (Sands Lab, Internal Medicine)
    “Three-Pronged Combination Therapy Dramatically Improves  Disease Course in Mouse model of Krabbe Disease”
  • Jonathan Power (Petersen Lab, Neurology)
    “Severity and breadth of cognitive impairment after lesions is  predicted by node integration in human resting state MRI networks”

Session 2: Neurovascular Injury & Repair (Chair: Jeff Gidday (Neurosurgery))

  • Lillian Cruz-Orengo (Klein Lab, Internal Medicine)
    “Sexually dimorphic expression of S1PR2 and its role in female  susceptibility to CNS autoimmunity”
  • Brian Soetikno (Wang and Lee Labs, Biomedical Engineering and Neurology)
    “Multi-parameter Photoacoustic Microscopy of Ischemic Stroke”
  • Adam Eggebrecht (Culver Lab, Radiology)
    “Bedside monitoring of resting state functional connectivity networks in acute ischemic stroke patients using diffuse optical tomography”

Genomics & Pathology Services (GPS): Jeff Millbrandt (Genetics)

Hope Center Lecture: Ryan Watts (Genentech)
“Crossing the Blood-Brain Barrier with Therapeutic Antibodies”

Session 3: Neurodegeneration (Chair: Marc Diamond (Neurology))

  • Kevin Stein (True Lab, Cell Biology & Physiology)
    “DNAJB6 mutations associated with dominantly-inherited myopathy have remarkably selective binding of specific conformations of client proteins”
  • David Sanders (Diamond Lab, Neurology)
    “Generation and propagation of tau prion strains in dividing mammalian cells”
  • Kaoru Yamada (Holtzman Lab, Neurology)
    “Excitatory neuronal activity regulates extracellular tau in vivo”
  • Sarah DeVos (Miller Lab, Neurology)
    “Tau Knockdown in the Adult Mouse Significantly Reduces Severity of Excitotoxic Seizures”

Session 4: Neurogenetics (Chair: Christina Gurnett (WUSTL Neurology))

  • Tao Sun (Rubin Lab, Pediatrics)
    “Cell-intrinsic Sex Differences Underlie the Male Prevalence in  Glioma Incidence”
  • Sheng-Chih (Peter) Jin (Cruchaga Lab, Psychiatry)
    “CSF biomarker as endophenotypes to infer functional mechanisms  of the Alzheimer’s disease GWAS-identified genes”
  • Laura Heitsch (Assistant Professor, Emergency Medicine)
    “Genetics of early stroke recovery”

Poster session

2012 Retreat: March 13, Danforth Plant Science Center


Alison Goate, Opening Remarks

Session 1: Axon Injury & Repair

  • Jung Eun Shin (DiAntonio Lab, Developmental Biology)
    “Dual leucine zipper kinase is required for injury-induced axon regeneration”
  • Bogdan Beirowski (Milbrandt Lab, Genetics)
    “Modeling chronic axon loss by disruption of Schwann cell metabolic
  • Michael Vasek (Klein Lab, Internal Medicine)
    “CNS West Nile virus infection impairs adult neurogenesis and spatial memory in a murine recovery model”
  • Michael Bruchas (Anesthesiology)
    “Biased signaling at Opioid GPCRs controls differential stress-induced behavioral responses”

Session 2: Neurovascular Injury & Repair

  • Adam Bauer (Culver Lab, Radiology)
    “Optical imaging of functional connectivity deficits in mouse models of ischemic stroke”
  • Ananth Vellimana (Zipfel Lab, Neurosurgery)
    “MMP-9: A New  Player in Cerebral Vasospasm Pathophysiology”
  • Rajarshi Sengupta (Rubin Lab, Pediatrics)
    “GBM stem cell nice disrupting agents identified through novel high throughput compound library screen”

Update on Resources: DNA purification, ZFNs, and on-line registry

Session 3: Neurodegeneration

  • Laura Westerguard (True Lab, Cell Biology & Physiology)
    “External cellular environment mediates amyloid strain formation in yeast”
  • Najla Kfoury (Diamond Lab, Neurology)
    “Trans-cellular Propagation of Tau Aggregation by Fibrillar Species”
  • Jacob Basak (Holtzman Lab, Neurology)
    “Low-Density Lipoprotein Receptor Represents an Apolipoprotein E-Independent Pathway of Aβ Uptake and Degradation by Astrocytes”
  • Christine Wroge (Mennerick Lab, Psychiatry)
    “Synaptic NMDA Receptors Mediate Hypoxic Excitotoxic Death”
  • Andrew Yoo (Developmental Biology)
    “Generation of Human Neurons by MicroRNA-Mediated Conversion of Fibroblasts”

Session 4: Neurogenetics

  • Matt Harms (Neurology)
    “Mutations in DNAJB6 cause limb-girdle muscular dystrophy type 1D”
  • Bruno Benitez (Cruchaga Lab, Psychiatry)
    “CSPα, a synaptic protein, is mutated in adult neuronal ceroid lipofuscinosis”
  • Josiah Gerdts (Milbrandt Lab, Genetics)
    “High-throughput screening identifies novel genes required for Wallerian Degeneration in primary mouse neurons”
  • Albert Kim (Neurosurgery)
    “The anaphase-promoting complex in brain development”

Poster session

2011 Retreat: February 8, River Camp, St. Louis Zoo


Alison Goate (Hope Center Director), Opening Remarks

Axon Injury & Repair (moderator: Valeria Cavalli)

  • Martha Bhattacharya (DiAntonio Lab, Dept of Developmental Biology), “An In Vivo Neuronal RNAi Screen Identifies Molecules Controlling Axon Degeneration”
  • Adam Bero (Holtzman Lab, Dept of Neurology), “Evidence that neuronal activity regulates the regional vulnerability to amyloid-β deposition”
  • Kelly Monk (Assistant Professor, Dept of Developmental Biology), “A forward genetic screen in zebrafish uncovers new regulators of myelination”

Neurodegeneration (moderator: Alison Goate)

  • Jennifer Dulle (True Lab, Dept of Cell Biology & Physiology), “Endogenous amyloids”: Kinetics, structures, modifiers and phenotypes”
  • Kanchan Garai (Frieden Lab, Dept of Biochemistry & Molecular Biophysics), “How the self-association behavior of lipid-free apoE determines the isoform specificity of physiological properties”
  • Adish Dani (Assistant Professor, Dept of Pathology & Immunology), “Beyond the diffraction barrier: resolving synapse molecular architecture and function”

Hope Center Cores
*Alafi Neuroimaging*    *Animal Surgery*    *Transgenic Vectors*    *Viral Vectors*

Neurogenetics (moderator: Christina Gurnett)

  • Celeste Karch (Goate Lab, Dept of Psychiatry), “Functional effects of genetic variants associated with tauopathies: modeling changes in CSF tau”
  • Joseph Corbo (Assistant Professor, Dept of Pathology & Immunology), “Cis-regulatory mapping: a new approach to finding retinal disease genes”
  • Joseph Dougherty (Assistant Professor, Dept of Genetics), “Deconstructing cellular complexity for disorders of the nervous system”

Therapeutics & Diagnostics (moderator: Marc Diamond)

  • Philip Verghese (Holtzman Lab, Dept of Neurology), “CytNmat1 protects against neonatal hypoxia-ischemia induced CNS injury by inhibiting excitotoxic but not caspase-dependent cell death in mice”
  • Rodrigo Fuentealba (Weihl Lab, Dept of Neurology), “Protein aggregate inhibition – Novel insights via High Throughput Screening technology”
  • Timothy Miller (Assistant Professor, Dept of Neurology), “Gene Downregulation as a Therapy for Neurodegenerative Disease”