About
The Hope Center Program on Protein Aggregation and Neurodegeneration (HPAN) is one of five Interdisciplinary Research Centers (IRCs) selected by the Dean of Washington University School of Medicine. As a BioMed 21 IRC, HPAN was awarded support from the Dean, and space in the new BJC Institute of Health (BJC-IH).
Below are those HPAN labs that are based in the BJC-IH. For the complete list of HPAN labs, click here.
Carlos Cruchaga Lab
Next-gen sequencing technology to identify genetic variants implicated in neurodegeneration
Anne Fagan Lab
Cerebrospinal fluid and plasma biomarkers of early-stage Alzheimer’s disease
David Holtzman Lab
Cellular/Molecular/Biomarker studies of Alzheimer’s disease and neonatal brain injury
Celeste Karch Lab
Molecular mechanisms underlying tauopathies
Jin-Moo Lee Lab
Amyloid plaque pathogenesis
Erik Musiek Lab
Aging, oxidative stress, and circadian clock genes in neurodegenerative diseases.
Steven Paul Lab
Understanding how apoE contributes to the clearance and metabolism of Aβ in Alzheimer’s disease
Itender Singh Lab
Neurovascular dysfunction in Alzheimer’s disease (AD) and stroke.
Greg Zipfel Lab
Role of amyloid-ß peptide and cerebral amyloid angiopathy in neurovascular dysfunction, ischemic brain injury and subarachnoid hemorrhage
