BioMed 21 IRC

HPAN is one of several BioMed 21 Interdisciplinary Research Centers (IRCs) in the BJC Institute of Health. Read More


The Hope Center Program on Protein Aggregation and Neurodegeneration (HPAN) is one of five Interdisciplinary Research Centers (IRCs) selected by the Dean of Washington University School of Medicine.  As a BioMed 21 IRC, HPAN was awarded support from the Dean, and space in the new BJC Institute of Health (BJC-IH).

Below are those HPAN labs that are based in the BJC-IH.  For the complete list of HPAN labs, click here.

Randall Bateman Lab

Alzheimer’s Disease: Pathophysiology, biomarkers, predictive diagnostics and treatments

Bruno Benítez Lab

Integration of phenotypic data with genomic, transcriptomic and proteomic data of individuals with neurodegenerative diseases

Carlos Cruchaga Lab

Next-gen sequencing technology to identify genetic variants implicated in neurodegeneration

Anne Fagan Lab

Cerebrospinal fluid and plasma biomarkers of early-stage Alzheimer’s disease

Oscar Harari Lab

Identification of “omics” (proteomic, transcriptomic and genetic) factors associated with neurodegeneration

David Holtzman Lab

Cellular/Molecular/Biomarker studies of Alzheimer’s disease and neonatal brain injury

Celeste Karch Lab

Molecular mechanisms underlying tauopathies

Geraldine Kress Lab

Role of circadian function on memory during aging and Alzheimer’s disease (AD) progression

Jin-Moo Lee Lab

Amyloid plaque pathogenesis

Erik Musiek Lab

Aging, oxidative stress, and circadian clock genes in neurodegenerative diseases

Steven Paul Lab

Understanding how apoE contributes to the clearance and metabolism of Aβ in Alzheimer’s disease

Greg Zipfel Lab

Role of amyloid-ß peptide and cerebral amyloid angiopathy in neurovascular dysfunction, ischemic brain injury and subarachnoid hemorrhage

HPAN Resources

HPAN provides resources and environment to promote research.

HPAN Resources