BioMed 21 IRC

HPAN is one of five BioMed 21 Interdisciplinary Research Centers (IRCs) in the BJC Institute of Health. Read More


The Hope Center Program on Protein Aggregation and Neurodegeneration (HPAN) is one of five Interdisciplinary Research Centers (IRCs) selected by the Dean of Washington University School of Medicine.  As a BioMed 21 IRC, HPAN was awarded support from the Dean, and space in the new BJC Institute of Health (BJC-IH).

Below are those HPAN labs that are based in the BJC-IH.  For the complete list of HPAN labs, click here.

Carlos Cruchaga Lab

Next-gen sequencing technology to identify genetic variants implicated in neurodegeneration

Anne Fagan Lab

Cerebrospinal fluid and plasma biomarkers of early-stage Alzheimer’s disease

Henry Han Lab

Imaging and functional studies of cerebral vessels associated with neurovascular disease

David Holtzman Lab

Cellular/Molecular/Biomarker studies of Alzheimer’s disease and neonatal brain injury

Celeste Karch Lab

Molecular mechanisms underlying tauopathies

Jin-Moo Lee Lab

Amyloid plaque pathogenesis

Erik Musiek Lab

Aging, oxidative stress, and circadian clock genes in neurodegenerative diseases.

Richard Perrin Lab

Novel cerebrospinal fluid biomarkers for early diagnosis, prognosis, and staging of neurodegenerative diseases.

Itender Singh Lab

Greg Zipfel Lab

Role of amyloid-ß peptide and cerebral amyloid angiopathy in neurovascular dysfunction, ischemic brain injury and subarachnoid hemorrhage


HPAN Resources

HPAN provides resources and environment to promote research.

HPAN Resources