The Hope Center Program on Protein Aggregation and Neurodegeneration (HPAN) is one of five Interdisciplinary Research Centers (IRCs) selected by the Dean of Washington University School of Medicine. As a BioMed 21 IRC, HPAN was awarded support from the Dean, and space in the new BJC Institute of Health (BJC-IH).
Below are those HPAN labs that are based in the BJC-IH. For the complete list of HPAN labs, click here.
Alzheimer’s Disease: Pathophysiology, biomarkers, predictive diagnostics and treatments
Next-gen sequencing technology to identify genetic variants implicated in neurodegeneration
Cerebrospinal fluid and plasma biomarkers of early-stage Alzheimer’s disease
Discovering mechanisms of neurodegeneration for potential therapeutic intervention
Identification of “omics” (proteomic, transcriptomic and genetic) factors associated with neurodegeneration
Cellular/Molecular/Biomarker studies of Alzheimer’s disease and neonatal brain injury
Molecular mechanisms underlying tauopathies
Amyloid plaque pathogenesis
Aging, oxidative stress, and circadian clock genes in neurodegenerative diseases
Understanding how apoE contributes to the clearance and metabolism of Aβ in Alzheimer’s disease
Role of amyloid-ß peptide and cerebral amyloid angiopathy in neurovascular dysfunction, ischemic brain injury and subarachnoid hemorrhage