Annual Retreat

Thursday November 19, 2020 Read More

Stay tuned for details about the special 10th Annual Hope Center Retreat, scheduled for November 19, 2020!


The ninth annual Hope Center Retreat was Tuesday, April 16, 2019 at the Danforth Plant Science Center, featuring Guoping Feng (Massachusetts Institute of Technology) and Sally Temple (Neural Stem Cell Institute).

Guoping Feng: “Dissecting synaptic and circuitry mechanisms of psychiatric disorders”
Sally Temple: “Neural stem cells in aging and modeling neurodegenerative disease”


The Hope Center Annual Retreat provides an opportunity to go off-site for a day, focus on Hope Center research, and learn more about translational Neuroscience outside Washington University: Hope Center faculty and members of their laboratories learn about the latest findings and future directions of member labs in the context of short talks and a poster session; the Hope Center Lecture features an invited speaker who leads his/her field with a research program aligned with the Hope Center mission.

2019 Retreat Program Summary

Tuesday, April 16, 2019

8:30a      Continental Breakfast (Lower Atrium)

9:00a      Welcome and Opening Remarks – David Holtzman, MD and Anneliese Schaefer, JD, PhD

9:05a      Session 1: Lysosome Processing & Transport Group
Lysosome Chair: Bruno Benitez, MD (Psychiatry)

  • Leah Czerniewski (Lee Lab, Neurology)
    “Tracking the intracellular itinerary of APP and de novo Aβ generation using click chemistry”
  • Andrew Findlay, MD (Weihl Lab, Neurology)
    “Lithium chloride corrects weakness and myopathology in a preclinical model of LGMD1D”

9:35a      Session 2: Protein Aggregation & Neurodegeneration Group
Neurodegeneration Chair: Timothy Miller, MD, PhD (Neurology)

  • Fabia Filipello, PhD (Piccio Lab, Neurology/Karch Lab, Psychiatry)
    “The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer disease risk”
  • Rachel French, PhD (Ayala Lab, SLU Biochemistry)
    “TDP-43 oligomers detected as initial intermediate species during aggregate formation“

10:05a      Session 3: Neurogenetics & Transcriptomics Group
Neurogenetics Chair: Oscar Harari, PhD (Psychiatry)

  • Matthew Lalli, PhD (Mitra/Milbrandt Labs, Genetics)
    “Rapid high-throughput single-cell neurodevelopmental disease modeling”
  • Michael Vasek, PhD (Dougherty Lab, Genetics)
    “Microglia: Local translation and synaptic homeostasis”

11:00a      Hope Center Lecture – Guoping Feng, PhD (Massachusetts Institute of Technology)
“Dissecting synaptic and circuitry mechanisms of psychiatric disorders”

12:00p Lunch

1:15p      Hope Center Lecture – Sally Temple, PhD (Neural Stem Cell Institute)
”Neural stem cells in aging and modeling neurodegenerative disease”

2:15p      Session 4:  Clocks & Sleep Club and NeuroRestorative Therapy Group
Clocks & Sleep Chair: Yao Chen, PhD (Neuroscience)
NeuroRestorative Chair: Fumihiko Urano, MD, PhD (Medicine) 

  • Percy Griffin (Musiek Lab, Neurology)
    Circadian regulation of neuroinflammation and neurodegeneration by Rev-erbα
  • Sindhu Manivasagam (Klein Lab, Medicine)
    “Investigating type III interferons as a novel therapeutic target during autoimmune neuroinflammation”

2:45p      Session 5:   Neurovascular Injury & Repair and Axon Injury & Repair Groups
Neurovascular Chair: Jin Moo Lee, MD, PhD (Neurology)
Axon Chair: Valeria Cavalli, PhD  (Neuroscience)

  •  Hailun Li (DiAntonio Lab, Developmental Biology)
    “A novel potassium buffering mechanism for neuroprotection against ischemic stroke
  • Satya Kothapalli, PhD (Yablonskiy Lab, Radiology)
    “In vivo measurements of Alzheimer disease-related neuronal loss in the hippocampal subfields with quantitative Gradient Recalled Echo (qGRE) MRI”

3:15p      Poster set-up 

3:30p      Poster session – Light refreshments and hors d’oeuvres

5:45p      Shuttle departs for WUSM


Hope Center Awards

Hope Center Award winners are selected from presenters at the Hope Center Retreat. To learn about past winners, click here.

Retreat 2018

The 8th annual Hope Center Retreat was held at the Danforth Plant Science Center on April 10, 2018.

2018 Retreat Program