Annual Retreat

Tuesday April 16, 2019 Read More

Registration is open!

Registration is free, and required for all who plan to attend. (Even if you submitted an abstract, you still are required to separately register.)

Register here!


The ninth annual Hope Center Retreat is Tuesday, April 16, 2019 at the Danforth Plant Science Center, featuring Guoping Feng (Massachusetts Institute of Technology) and Sally Temple (Neural Stem Cell Institute).

Guoping Feng: “Dissecting synaptic and circuitry mechanisms of psychiatric disorders”
Sally Temple: “Neural stem cells in aging and modeling neurodegenerative disease”

For questions about the Annual Retreat, please contact Celeste Karch or Carlos Cruchaga.

Check back for the full retreat schedule. You will find it below and also on the Office of Neuroscience Research (ONR) Calendar.


The Hope Center Annual Retreat provides an opportunity to go off-site for a day, focus on Hope Center research, and learn more about translational Neuroscience outside Washington University: Hope Center faculty and members of their laboratories learn about the latest findings and future directions of member labs in the context of short talks and a poster session; the Hope Center Lecture features an invited speaker who leads his/her field with a research program aligned with the Hope Center mission.

2018 Retreat program

Tuesday, April 10, 2018

8:00a    Shuttle departs from the Farrell LTC (660 S. Euclid)

8:30a    Continental Breakfast

9:00a    Welcome and Opening Remarks from David Holtzman, MD and Anneliese Schaefer, JD, PhD

9:05a    Hope Center Lecture – Leonard Petrucelli, PhD (Mayo Clinic Florida) 

“Mechanistic and Therapeutic Insights into c9FTD/ALS”

10:05a    Session 1: Neurodegeneration Group (Chair: Timothy Miller, MD, PhD (Neurology))

  • Kiersten Ruff, PhD (Pappu Lab, Biomedical Engineering)
    “Polyglutamine length dependent structural properties and phase behavior of huntingtin exon 1”
  • Tien-Phat Huynh (Holtzman Lab, Neurology)
    “Age-dependent effects of apoE reduction using antisense oligonucleotides in a model of β-amyloidosis”

10:35a    Break

11:00a    Session 2: Lysosome Processing & Transport Group (Chair: Bruno Benitez, MD (Medicine)); NeuroRestorative Therapy Group (Chairs: Albert Kim, MD, PhD (Neurosurgery) and Fumihiko Urano, MD, PhD (Medicine))

  • Devi Annamalai, PhD (Kim Lab, Neurosurgery)
    “Epigenomic reprogramming as a therapeutic strategy for malignant gliomas”
  • Sidhartha Mahali, PhD (Karch Lab, Psychiatry)
    “Lysosomal dysfunction and altered tau metabolism in stem cell models of autosomal dominant Alzheimer’s disease”

11:30a    Session 3: Neurovascular Injury & Repair Group (Chair: Jin-Moo Lee, MD, PhD (Neurology))

  • Charise Garber (Klein Lab, Medicine)
    “T-cells promote microglial activation and prevent cognitive recovery from viral encephalitis via interferon gamma”
  • Deepti Diwan, PhD (Zipfel Lab, Neurosurgery)
    “Sirt1 mediates hypoxic conditioning-induced delayed cerebral ischemia protection in subarachnoid hemorrhage”

12:00p    Lunch

1:15p    Session 4: Neurogenetics & Transcriptomics Group (Chair: Carlos Cruchaga, PhD (Psychiatry))

  • Umber Dube (Cruchaga Lab, Psychiatry)
    “Circular RNAs in Alzheimers disease brain tissues”
  • Denis Avey, PhD (Milbrandt Lab, Genetics)
    “Single cell RNA-seq facilitates characterization of glial and neuronal responses to morphine”

1:45p    Session 5: Axon Injury & Repair Group (Chair: Valeria Cavalli, PhD (Neuroscience))

  • Scott Karney-Grobe (DiAntonio Lab, Developmental Biology)
    “HSP90 is a chaperone for DLK and is required for axon injury signaling”
  • Deng Pan (Mackinnon Lab, Surgery)
    “Reduced T cell accumulation in long gap nerve injuries inhibit peripheral nerve regeneration”

2:15p    Poster set-up

2:30p    Poster session

Hope Center Awards

Hope Center Award winners are selected from presenters at the Hope Center Retreat. To learn about this year’s winners, Scott Karney-Grobe and Alex Cammack, as well as a list of past winners, click here.

Retreat 2018

The 8th annual Hope Center Retreat was held at the Danforth Plant Science Center on April 10, 2018.

2018 Retreat Program