Annual Retreat

Tuesday May 9, 2017 Read More


The Hope Center Annual Retreat provides an opportunity to go off-site for a day, focus on Hope Center research, and learn more about translational Neuroscience outside Washington University: Hope Center faculty and members of their laboratories learn about the latest findings and future directions of member labs in the context of short talks and a poster session; the Hope Center Lecture features an invited speaker who leads his/her field with a research program aligned with the Hope Center mission.  The seventh annual Hope Center Retreat will be held on Tuesday, May 9, 2017 at the Danforth Plant Science Center and feature Laura Ranum (University of Florida) as the Hope Center Lecturer.  We also will hear from Rod Corriveau (NIH/NINDS).  Details can be found below and also on the Neuroscience Calendar of the Office of Neuroscience Research.

For questions about the Annual Retreat, please contact Celeste Karch or Carlos Cruchaga.

2017 Retreat program

8:30a   Continental Breakfast (Lower Atrium)

9:00a   Welcome and Opening Remarks from David Holtzman, MD and Anneliese Schaefer, JD, PhD

9:05a   Session 1: Neurogenetics & Transcriptomics (Chair: Carlos Cruchaga, PhD (Psychiatry))

  • Kristina Sakers (Dougherty Lab, Genetics)
    “Astrocyte local translation and the role of quaking RNA binding protein in mRNA export and protein stability”
  • Victoria Fernandez, PhD (Cruchaga Lab, Psychiatry)
    “Novel candidate variants in late onset Alzheimer Disease detected by the Familial Alzheimer Sequencing (FASe) Project”

9:35a    Session 2: Neurovascular Injury & Repair (Chair: Jin-Moo Lee, MD, PhD (Neurology))

  • Hamid Salimi, PhD (Klein Lab, Neuroscience)
    “Encephalitic alphaviruses: neurotropism and mechanisms of CNS entry”
  • Zachary Rosenthal (Lee Lab, Neurology)
    “Recovery of cortical delta band functional connectivity after focal ischemia”

10:05a    Session 3: Axon Injury & Repair (Chair: Valeria Cavalli, PhD (Neuroscience))

  • Kow Essuman (Milbrandt Lab, Genetics)
    “Identification of the NAD+ consuming enzyme that promotes axonal death during injury and disease”
  • Young Mi Oh, PhD (Cavalli Lab, Neuroscience)
    “miRNA-9 regulates axon regeneration through modulation of the epigenetic factor UHRF1 and the transcriptional regulator REST”

10:35a    Break

11:00a    Roderick Corriveau, PhD (NIH/NINDS)

“NINDS Mission, AD/ADRD Research Initiatives, Training and Diversity Career Development”

12:00p    Lunch

1:15p    Hope Center Lecture:  Laura Ranum, PhD (University of Florida)

“Repeat associated non-ATG (RAN) translation: new starts and directions in neurologic disease”

 2:15p     Session 4: Neurodegeneration (Chair: Timothy Miller, MD PhD (Neurology))

  • Yang Shi, PhD (Holtzman Lab, Neurology)
    “Effect of apolipoproteinE on tau pathogenesis and tau-mediated neurodegeneration”
  • Min-Yu Sun, PhD (Mennerick Lab, Psychiatry)
    “A chemogenetic approach reveals synaptic contributions of δ subunit-containing GABAA receptors in dentate granule neurons”

2:45p    Session 5: Lysosome Processing & Transport and NeuroRestorative Therapy (Chairs: Bruno Benitez, MD and Fumihiko Urano, MD PhD (Medicine))

  • Yedda Li (Mark Sands, Genetics)
    “Combination therapy increase lifespan and improves clinicobehavioral performance in the murine model of globoid cell leukodystrophy”
  • Daniel Abernathy (Andrew Yoo, Developmental Biology)
    “MicroRNA-induced epigenetic remodeling during direct cell-fate conversion of adult human fibroblasts”

3:15p     Break / Poster set-up

3:30p     Poster session (Upper Atrium)

5:45p     Shuttle departs for WUSM

Hope Center Awards

Hope Center Award winners will be selected from presenters at the Hope Center Retreat.  For more about these awards including past winners, click here.


Retreat 2016

The sixth annual Hope Center Retreat was held at the Danforth Plant Science Center on May 3, 2016.

2016 Retreat Program


For previous year's programs, click the links below.

2015 Retreat Program

2014 Retreat Program

2013 Retreat Program

2012 Retreat Program

2011 Retreat Program