About HPAN

Hope Center Program on Protein Aggregation and Neurodegeneration Read More


The Hope Center Program on Protein Aggregation and Neurodegeneration (HPAN) is an interdisciplinary program that aims to find diagnostic tools and effective treatments for neurodegenerative diseases by investigating their underlying cause.  As part of the larger Hope Center for Neurological Disorders, HPAN faculty work together towards the specific aims:

  • Discover genetic alterations that lead to familial forms of neurodegenerative disease or alter disease risk for sporadic cases.
  • Understand the biochemical and cell biological processes that control metabolism of proteins that misfold in neurodegenerative disorders.
  • Use animal models of neurodegenerative disorders to better understand disease pathogenesis and to develop treatments.
  • Perform translational studies in humans to understand metabolism of proteins prone to aggregate in neurodegenerative disorders to develop better diagnostic and treatment methods.

Accomplishing these goals will provide insight to underlying molecular mechanisms of disease, and better ways to diagnose and treat neurodegenerative diseases.

HPAN laboratories use complementary approaches to address questions of protein aggregation in disease.  A subset of these labs are located in the BJC Institute of Health, an inititative of BioMed 21.


HPAN Director

David Holtzman

Research Group Meetings

Monthly Neurodegeneration 'lab meetings' and PI Chalk Talks provide an opportunity to share progress and get feedback.

Neurodegeneration Group