Category: Neurogenetics & Transcriptomics

Focused ultrasound technique gets quality assurance protocol

For the past several years, Washington University in St. Louis researchers have been using focused ultrasound combined with microbubbles to target an opening in the tough, protective blood-brain barrier to deliver drugs or retrieve biomarkers. To ensure that the fast-developing technology functions safely and consistently, Hong Chen, PhD, and her team, including first author and […]

Immunotherapy for Alzheimer’s disease shows promise in mouse study

Alzheimer’s disease starts with a sticky protein called amyloid beta that builds up into plaques in the brain, setting off a chain of events that results in brain atrophy and cognitive decline. The new generation of Alzheimer’s drugs — the first proven to change the course of the disease — work by tagging amyloid for […]

Gordon receives Nemmers Prize

Jeffrey I. Gordon, MD, of Washington University School of Medicine in St. Louis, has received the 2024 Mechthild Esser Nemmers Prize in Medical Science from Northwestern University. Gordon was selected for the prize by a jury of distinguished U.S. scientists for transforming the understanding of human health and how it is shaped by the gut […]

Three named 2023 Young Investigator grantees

Sarah D. Ackerman, PhD, Gabor Egervari, MD, PhD and Tao Xie, PhD, all of Washington University School of Medicine in St. Louis, have been named 2023 Young Investigator grantees by the Brain & Behavior Research Foundation. This year’s funding will support 150 promising early-career scientists across the field of neuropsychiatry with innovative ideas in mental health research. The two-year grant […]

Yi and Gabel receive grants to study autism-related disorders

Jason Yi, PhD, an assistant professor of neuroscience, and Harrison Gabel, PhD, an associate professor of neuroscience, both at Washington University School of Medicine in St. Louis, each have received two-year $300,000 pilot grants from the Simons Foundation Autism Research Initiative. The researchers will use the funds to investigate genetic diseases that result in autism. […]

New Technique for Diagnosing Brain Diseases is Successfully Put to the Test

Hong Chen, PhD, associate professor of biomedical engineering and radiation oncology at Washington University in St. Louis, is dedicated to what may seem like the impossible. “This constant puzzle of what’s happening in my brain.” Chen is referring to all human brains that share this complexity. And getting answers to serious problems can be very […]

NIH funds study of ultrasound with genetics to treat brain disorders

Researchers have developed methods to study and manipulate areas of the brain, though many of those methods are restricted by the limited depth that light can reach within the brain. A multidisciplinary team at Washington University in St. Louis plans to overcome that limitation by integrating ultrasound with genetics to precisely modify neurons in the […]

Tau-based biomarker tracks Alzheimer’s progression

Two pathologies drive the progression of Alzheimer’s disease. Early on, amyloid beta plaques lead the way, but around the time cognitive symptoms arise, tau tangles take over as the driving force and cognition steadily declines. Tracking the course of the disease in individual patients has been challenging because there’s been no easy way to measure […]

Gordon wins Spain’s Asturias Award

Microbiome pioneer Jeffrey I. Gordon, MD, of Washington University School of Medicine in St. Louis, has won the 2023 Princess of Asturias Award for Technical and Scientific Research. The Asturias awards, among the most prestigious honors in the Spanish-speaking world, are presented annually in eight categories. The awards are designed to recognize exceptional scientific, technical, cultural, […]

Induction of a torpor-like state with ultrasound

Some mammals and birds have a clever way to preserve energy and heat by going into torpor, during which their body temperature and metabolic rate drop to allow them to survive potentially fatal conditions in the environment, such as extreme cold or lack of food. While a similar condition was proposed for scientists making flights […]

Findings may lead to improved insulin-secreting cells derived from stem cells

Diabetes researchers at Washington University School of Medicine in St. Louis have uncovered at least one reason insulin-secreting cells made from stem cells in the lab don’t work as well as natural cells. The discovery could help speed progress toward making insulin-secreting cells — called islet beta cells — more effective in the treatment of […]

Bagnall wins grant to map neuronal connections

Martha Bagnall, PhD, an assistant professor of neuroscience at Washington University School of Medicine in St. Louis, received a $1.9 million R01 grant from the National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health (NIH), to map neuronal connections in the zebrafish spinal cord. The Bagnall lab studies motor control […]

Insight into brain’s waste clearing system may shed light on brain diseases

Like the lymphatic system in the body, the glymphatic system in the brain clears metabolic waste and distributes nutrients and other important compounds. Impairments in this system may contribute to brain diseases, such as neurodegenerative diseases and stroke. A team of researchers in the McKelvey School of Engineering at Washington University in St. Louis has […]

Gabel Lab identifies molecular links between Sotos and Tatton Brown Rahman Syndromes

Sotos Syndrome and Tatton Brown Rahman Syndrome bear striking similarities, so much so that patients with one have been misdiagnosed as having the other. Both rare diseases cause large stature and head size, also known as overgrowth, distinct facial features, a high prevelance of autism, and intellectual disability. But the two diseases have different genetic […]

Adding med to antidepressant may help older adults with treatment-resistant depression

For older adults with clinical depression that has not responded to standard treatments, adding the drug aripiprazole (brand name Abilify) to an antidepressant they’re already taking is more effective than switching from one antidepressant to another, according to a new multicenter study led by Washington University School of Medicine in St. Louis. Aripiprazole originally was […]

Board of Trustees grants tenure

At the Washington University in St. Louis Board of Trustees meeting Dec. 2, several faculty members were granted tenure. Their new roles took effect Dec. 2. Granting of tenure Marlon M. Bailey as professor of African and African American studies and of women, gender, and sexuality studies, both in Arts & Sciences; Adam Q. Bauer, PhD as […]

New center’s aim: To ID biomarkers of neurodegenerative diseases

A new center established at Washington University School of Medicine in St. Louis aims to accelerate research into biomarkers of neurodegenerative conditions such as Huntington’s and Parkinson’s diseases, amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS) and the so-called tauopathies, a group that includes Alzheimer’s disease along with rarer diseases such as frontotemporal dementia, corticobasal syndrome […]

Wearable ultrasound sensors for human brain in development

A submarine can inadvertently reveal its location because of cavitation, a condition that creates bubbles underwater that burst, then emit sound waves that can be detected by sonar. A team of biomedical engineers at Washington University in St. Louis plans to use the same concept to detect cavitation in human brains that may contribute to […]